Abstract: To study the anti-inflammatory effect and mechanism of Huajiao-6 decoction, used the xylene-induced inflammation,paw swelling,acetic acid to make the permeabitity of blood capillaries and cotton pellet-induced granuloma method in mice.Determined the ear swelling,paw edema caused by egg white and formaldehyde and cotton pellet induced granuloma after administration.The adjuvant arthritis(AA) rat model was made, then,the activity of IL-1β,IL-6 and TNF-α of AA rat were determined by the method of ELISA. Huajiao-6 decoction significantly inhibited the acute inflammation in mice induced by xylene as well as the acetic acid to make the permeabitity of blood capillaries,subacute inflammation model caused by egg white and formaldehyde and the chronic inflammation model aroused by intradermal implantation cotton pellet. Huajiao-6 had significant inhibition on inflammation, the content of IL-1β,IL-6 and TNF-α in serum of AA rat were significantly reduced by Huajiao-6 decoction. The results showed that Huajiao-6 decoction had the inhibitory effect on the activity of inflammatory mediums and responds, it could be used to treat RA.

Key words: Huajiao-6; rheumatoid arthritis; anti-inflammatory effect; anti-inflammatory mechanism; cytokines