Abstract: A pharmaceutical susceptibility and clinical test of pathogenic isolated from chicken in Jinzhou district veterinary station was done, in order to observe the effect which three antibacterial killed and inhibited E. coli of chicken. The antibacterial was Junpusha，Qinjunkang and compound ampicillin soluble powder. The pharmaceutical susceptibility test was done by means of paper, all results showed that Junpusha was the best sensitive, Qinjunkang was highly sensitivity by two means to preparing bacterial hanging fluid. Clinical test used Junpusha 、and compound ampicillin soluble powder to carry on the grouping experiment, chicken of E.coli disease 300, each group of 100, four repetition inner group. The results showed that the average cure rate was 98.2% of Junpusha, 96.2% of Qinjunkang and 92.3% of compound ampicillin soluble powder. The clinical efficacy of compound ampicillin soluble powder was instability for distinct difference inner group. The clinical efficacy of Junpusha was best good in three antibacterial, the clinical efficacy of Qinjunkang as Chinese traditional combination medicine was also good. This test provided a reference for prevention and cure the E. coli disease from chicken in Jinzhou district.

Key words: Escherichia coli; pharmaceutical susceptibility test; antibacterial; efficacy