Abstract: Staphylococcus aureus is one of the main pathogenic bacteria of mastitis in dairy cow. Once infected, it is difficult to eradicate with available therapies. The studies on dairy cow mastitis presented stagnation because of its complicated pathogenesis and clinical progression. Researchers had begun to focus their research on establishing animal models. In this article, the experimental mouse model of S.aureus mastitis is established in order to study fibronectinbinding protein(FnBP), secreted toxins and the smallcolony variant(SCV). Results are helpful to discover the pathogenesis of S.aureus and develop new therapeutic approaches.

Key words: Staphylococcus aureus; mastitis; mouse model; dairy cow