China Animal Husbandry and Veterinary Medicine ›› 2024, Vol. 51 ›› Issue (2): 875-882.doi: 10.16431/j.cnki.1671-7236.2024.02.043

• Basic Veterinary Medicine • Previous Articles     Next Articles

Research Progress on the Protective Effect of Baicalin on Intestinal of Animals

HE Zhengke1, SU Lijuan1, TAN Xiaoyan1, LI Zhangxun1, CAO Liting1,2, MA Yue1,2, DU Hongxu1,2   

  1. 1. College of Veterinary Medicine, Southwest University, Chongqing 402460, China;
    2. Institute of Traditional Chinese Veterinary Medicine, Southwest University, Chongqing 402460, China
  • Received:2023-09-09 Online:2024-02-05 Published:2024-01-29
  • Contact: 重庆市自然科学基金面上项目(CSTB2022NSCQ-MSX0470);国家生猪技术创新中心先导科技项目(NCTIP-XD/B12);北京农学院兽医学(中医药)北京市重点实验室开放课题(BUAPSP202205);重庆市现代农业产业技术体系(CQMAITS202312)

Abstract: Baicalin is a kind of flavonoid active substance extracted from the root of Scutellaria baicalensis.Under alkaline environment, the chemical properties of baicalin are unstable, and the glycoside bond in its molecular structure is easily hydrolyzed and the o-diphenol hydroxyl group is easily oxidized.The presence of sugar groups in the molecular structure of baicalin makes it almost insoluble in water, which limits its clinical application.Baicalin is not easily absorbed in the intestine, but under the action of β-glucuronidase produced by intestinal microbes, its glycosyl is removed and converted into baicalin, which is more easily absorbed by the intestine.The metabolites of baicalein were excreted in bile or urine after glucosylation, glucosylation, methylation and hydrolysis in animals.Pharmacological studies have found that it has anti-inflammatory, antibacterial, antiviral, anti-tumor and anti-intestinal damage pharmacological activities.Based on the bibliometrics analysis of the relevant literature in recent years, it is found that the research attention of baicalin in animal intestinal protection is increasing.In order to more comprehensively review the current research status of baicalin in animal intestinal protection, the author reviewed the effects of baicalin on animal intestinal pathogenic microorganisms and maintenance of intestinal barrier function homeostasis, aiming to provide a reference for further research of baicalin and its clinical application in veterinary medicine.

Key words: baicalin; bibliometrics; pharmacologic action; intestinal protection; molecular mechanism

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