›› 2017, Vol. 44 ›› Issue (6): 1890-1894.doi: 10.16431/j.cnki.1671-7236.2017.06.044

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Effect of Baicalin on Cell Permeability of Escherichia coli

LIU Hao, ZHAO Zi-bing, WU Dan-dan, WANG Xin   

  1. College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China
  • Received:2016-12-28 Online:2017-06-20 Published:2017-06-28

Abstract:

The objective of this study was to explore the antibacterial mechanism of baicalin on Escherichia coli. Based on the determination of baicalin on Escherichia coli minimum inhibitory concentration (MIC) and growth curve, the influence of baicalin on Escherichia coli cells permeability was researched by measuring the conductivity and alkaline phosphatase (AKP) content of bacterial solution. The experimental results showed that baicalin had significantly inhibitory effect on Escherichia coli, and its MIC was 6.25 mg/mL.Baicalin could significantly increase the conductivity and AKP content of Escherichia coli bacteria solution.The results suggested that baicalin on antibacterial activity was mainly due to the changes of the cell membrane permeability and the damage of the cell wall.

Key words: baicalin; Escherichia coli; conductivity; alkaline phosphatase

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