锌的生理功能及其在猪养殖中的应用

doi:10.16431/j.cnki.1671-7236.2022.11.013

Abstract

Abstract: Zinc is an essential micromineral for physiological processes such as the growth, development, and breeding in animals, and it ranks only second to iron micromineral according to micronutrient requirements.Zinc is widely distributed with tissue differences and is mainly absorbed in jejunum and ileum of animal.Both zinc-regulated transporter-like proteins (Zip) and zinc transporter (ZnT) of Zinc transport proteins, and metallothionein involve in zinc balance and metabolism in animal.Zinc is the component and the activity factor of many enzymes in animal, it on the one hand regulates cell processes as the constituent of enzyme, and on the other hand involves signal transduction as the signal molecule to regulate animal physiological functions of feed intake, redox, immune, metabolism, reproduction.At present, dietary zinc mainly includes inorganic, organic, and nano-zinc styles, which display different biological value.Dietary zinc is associated with physiological functions on feed intake, redox, immune, metabolism, reproduction of pigs, while zinc requirement varies with swine nutrient requirements during different growth stages.In addition, physiological regulation and applicative effects of dietary zinc display variations due to zinc levels and sources.The purpose of this article is to provide theoretical references for the deep excavation of microelement zinc, thereby promoting the healthy development of pig industry.

Key words: zinc; physiological function; pigs

CLC Number:

S816.72

TIAN Zhimei, CUI Yiyan, DENG Dun, LU Huijie, LIU Zhichang, RONG Ting, LI Zhenming, SONG Min, YU Miao, MA Xianyong. Physiological Function of Micromineral Zinc and Its Application in Pig Breeding[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(11): 4228-4238.

References

[1] GOWALOCK D W, MAHAN D C, SAMUEL R S.Evaluating dietary adjustment and collection times for total tract digestibility of Ca, P, and the essential microminerals with grower swine[J].Journal of Animal Science, 2016, 94(8):3264-3270.
[2] KASPRZYK A, KILAR J, CHWIL S, et al.Content of selected macro- and microelements in the liver of free-living wild boars (Sus scrofa L.) from agricultural areas and health risks associated with consumption of liver[J].Animals (Basel), 2020, 10(9):1519.
[3] HARRIS E D.Minerals in Foods[M].Lancaster:DEstech Publications Inc., 2014.
[4] 杜绍范, 刘风翥, 王永民.猪营养与微量元素锌[J].辽宁畜牧兽医, 1998, 6:30-31. DU S F, LIU F Z, WANG Y M.Pig nutrition and micromineral zinc[J].Liaoning Animal Husbandry and Veterinary, 1998, 6:30-31.(in Chinese)
[5] 万炳华.动物必需微量元素锌[J].中国饲料, 1997, 6:25-26. WAN B H.Animal essential micromineral zinc[J].China Feed, 1997, 6:25-26.(in Chinese)
[6] ROMEO A, VACCHINA V, LEGROS S, et al.Zinc fate in animal husbandry systems[J].Metallomics, 2014, 6(11):1999-2009.
[7] LICHTEN L A, COUSINS R J.Mammalian zinc transporters:Nutritional and physiologic regulation[J].Annul Review of Nutrition, 2009, 29:153-176.
[8] JAROSZ M, OLBERT M, WYSZOGRODZKA G, et al.Antioxidant and anti-inflammatory effects of zinc.Zinc-dependent NF-κB signaling[J].Inflammopharmacology, 2017, 25(1):11-24.
[9] PIEPER R, DADI T H, PIEPER L, et al.Concentration and chemical form of dietary zinc shape the porcine colon microbiome, its functional capacity and antibiotic resistance gene repertoire[J].ISME Journal, 2020, 14(11):2783-2793.
[10] MA Y L, LINDEMANN M D, WEBB S F, et al.Evaluation of trace mineral source and preharvest deletion of trace minerals from finishing diets on tissue mineral status in pigs[J].Asian-Australasian Journal of Animal Science, 2018, 31(2):252-262.
[11] OLECHNOWICZ J, TINKOV A, SKALNY A, et al.Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism[J].Journal of Physiological Science, 2018, 68(1):19-31.
[12] 周宁, 李光玉, 张海华, 等.微量元素锌在动物生产中应用研究新进展[J].中国畜牧兽医, 2014, 41(2):106-110. ZHOU N, LI G Y, ZHANG H H, et al.New research progress on application of zinc in animal production[J].China Animal Husbandry & Veterinary Medicine, 2014, 41(2):106-110.(in Chinese)
[13] KODAMA H, TANAKA M, NAITO Y, et al.Japan's practical guidelines for zinc deficiency with a particular focus on taste disorders, inflammatory bowel disease, and liver cirrhosis[J].International Journal of Molecular Sciences, 2020, 21(8):2941.
[14] CAMPFIELD L A, SMITH F J, GUISEZ Y, et al. Recombinant mouse OB protein:Evidence for a peripheral signal linking adiposity and central neural networks[J].Science, 1995, 269(5223):546-549.
[15] 刘正旭, 占今舜, 霍永久.锌在猪生产中的应用研究进展[J].饲料博览, 2014, 1:21-24. LIU Z X, ZHAN J S, HUO Y J.Research progress of zinc in pig production[J].Feed Review, 2014, 1:21-24.(in Chinese)
[16] SCHWARTZ M W, SIPOLS A J, MARKS J L, et al.Inhibition of hypothalamic neuropeptide Y gene expression by insulin[J].Endocrinology, 1992, 130(6):3608-3616.
[17] HUBNER C, HAASE H.Interactions of zinc- and redox-signaling pathways[J].Redox Biology, 2021, 41:101916.
[18] QIAN L, YUE X, HU L, et al.Changes in diarrhea, nutrients apparent digestibility, digestive enzyme activities of weaned piglets in response to chitosan-zinc chelate[J].Animal Science Journal, 2016, 87(4):564-569.
[19] CEMIN H S, CARPENTER C B, WOODWORTH J C, et al.Effects of zinc source and level on growth performance and carcass characteristics of finishing pigs[J].Translational Animal Science, 2019, 3(2):742-748.
[20] MA Y, HUANG Q, LV M, et al.Chitosan-Zn chelate increases antioxidant enzyme activity and improves immune function in weaned piglets[J].Biological Trace Element Research, 2014, 158(1):45-50.
[21] GOMEZ-RIVAS L, ESCUDERO-ABARCA B I, AGUILAR-USCANGA M G, et al.Selective antimicrobial action of chitosan against spoilage yeasts in mixed culture fermentations[J].Journal of Industral Microbiology and Biotechnology, 2004, 31(1):16-22.
[22] MARET W.The redox biology of redox-inert zinc ions[J].Free Radical Biology and Medicine, 2019, 134:311-326.
[23] PIEPER R, MARTIN L, SCHUNTER N, et al.Impact of high dietary zinc on zinc accumulation, enzyme activity and proteomic profiles in the pancreas of piglets[J].Journal of Trace Elements in Medicine and Biology, 2015, 30:30-36.
[24] KARWEINA D, KREUZER-REDMER S, MULLER U, et al.The zinc concentration in the diet and the length of the feeding period affect the methylation status of the Zip4 zinc transporter gene in piglets[J].PLoS One, 2015, 10(11):e0143098.
[25] GUNTHER V, LINDERT U, SCHAFFNER W.The taste of heavy metals:Gene regulation by MTF-1[J]. Biochimical et Biophysica Acta, 2012, 1823(9):1416-1425.
[26] ABIRIA S A, KRAPIVINSKY G, SAH R, et al.TRPM7 senses oxidative stress to release Zn²⁺ from unique intracellular vesicles[J].Proceedings of the National Academy of Sciences of the United States of America, 2017, 114(30):6079-6088.
[27] ZHA A, CUI Z, QI M, et al.Dietary baicalin zinc supplementation alleviates oxidative stress and enhances nutrition absorption in deoxynivalenol challenged pigs[J].Current Drug Metabolism, 2020, 21(8):614-625.
[28] PEARCE S C, SANZ FERNANDEZ M V, TORRISON J, et al.Dietary organic zinc attenuates heat stress-induced changes in pig intestinal integrity and metabolism[J].Journal of Animal Science, 2015, 93(10):4702-4713.
[29] BAI M M, LIU H N, XU K, et al.Use of coated nano zinc oxide as an additive to improve the zinc excretion and intestinal morphology of growing pigs1[J].Journal of Animal Science, 2019, 97(4):1772-1783.
[30] SKRAJNOWSKA D, BOBROWSKA-KORCZAK B.Role of zinc in immune system and anti-cancer defense mechanisms[J].Nutrients, 2019, 11(10):2273.
[31] LI M Z, HUANG J T, TSAI Y H, et al.Nanosize of zinc oxide and the effects on zinc digestibility, growth performances, immune response and serum parameters of weanling piglets[J]. Animal Science Journal, 2016, 87(11):1379-1385.
[32] ANDREINI C, BANCI L, BERTINI I, et al.Zinc through the three domains of life[J].Journal of Proteome Research, 2006, 5(11):3173-3178.
[33] YATSUNYK L A, EASTON J A, KIM L R, et al.Structure and metal binding properties of znua, a periplasmic zinc transporter from Escherichia coli[J].Journal of Biological Inorganic Chemistry, 2008, 13(2):271-288.
[34] KABLE M E, RIAZATI N, KIRSCHKE C P, et al.The Znt7-null mutation has sex dependent effects on the gut microbiota and goblet cell population in the mouse colon[J].PLoS One, 2020, 15(9):e0239681.
[35] RATTIGAN R, SWEENEY T, VIGORS S, et al.Effects of reducing dietary crude protein concentration and supplementation with laminarin or zinc oxide on the faecal scores and colonic microbiota in newly weaned pigs[J].Journal of Animal Physiology and Animal Nutrition (Berl), 2020, 104(5):1471-1483.
[36] WANG J, LI C, YIN Y, et al.Effects of zinc oxide/zeolite on intestinal morphology, intestinal microflora, and diarrhea rates in weaned piglets[J].Biological Trace Element Research, 2021, 199(4):1405-1413.
[37] LIU H, BAI M, XU K, et al.Effects of different concentrations of coated nano zinc oxide material on fecal bacterial composition and intestinal barrier in weaned piglets[J].Journal of Science of Food and Agriculture, 2021, 101(2):735-745.
[38] SMITH JR J C, MCDANIEL E G, MCBEAN L D, et al.Effect of microorganisms upon zinc metabolism using germfree and conventional rats[J].Journal of Nutriton, 1972, 102(6):711-719.
[39] REED S, NEUMAN H, MOSCOVICH S, et al.Chronic zinc deficiency alters chick gut microbiota composition and function[J].Nutrients, 2015, 7(12):9768-9784.
[40] BOLICK D T, MEDEIROS P, LEDWABA S E, et al.Critical role of zinc in a new murine model of enterotoxigenic Escherichia coli diarrhea[J].Infection and Immunity, 2018, 86(7):e00183-18.
[41] JOHANNS V C, EPPING L, SEMMLER T, et al.High-zinc supplementation of weaned piglets affects frequencies of virulence and bacteriocin associated genes among intestinal Escherichia coli populations[J].Frontiers in Veterinary Science, 2020, 16(7):614513.
[42] 张得香, 朱秋杰, 刘振华, 等.微量营养素锌促进肠上皮发育及再生机制的研究进展[J].动物营养学报, 2020, 32(11):5038-5045. ZHANG D X, ZHU Q J, LIU Z H, et al.Research progress on mechanism of micronutrent zinc promoting development and regeneration of intestinal epithelium[J].Chinese Journal of Animal Nutrition, 2020, 32(11):5038-5045.(in Chinese)
[43] WANG L, URRIOLA P E, LUO Z H, et al.Metabolomics revealed diurnal heat stress and zinc supplementation-induced changes in amino acid, lipid, and microbial metabolism[J].Physiological Reports, 2016, 4(1):e12676.
[44] SZABO J, HEGEDUS M, BRUCKNER G, et al.Large doses of zinc oxide increases the activity of hydrolases in rats[J].Journal of Nutritional Biochemistry, 2004, 15(4):206-209.
[45] HOLEN J P, JOHNSTON L J, URRIOLA P E, et al.Comparative digestibility of polysaccharide-complexed zinc and zinc sulfate in diets for gestating and lactating sows[J].Journal of Animal Science, 2020, 98(4):skaa079.
[46] FOSTER M, SAMMAN S.Zinc and redox signaling:Perturbations associated with cardiovascular disease and diabetes mellitus[J].Antioxidants and Redox Signaling, 2010, 13(10):1549-1573.
[47] BEYERSMANN D, HAASE H.Functions of zinc in signaling, proliferation and differentiation of mammalian cells[J].Biometals, 2001, 14(3-4):331-341.
[48] MENDONCA M V, NAKASONE D H, MARTINEZ C H G, et al.Copper and zinc hydroxychloride cosupplementation improve growth performance and carcass and reduce diarrhea frequency in grower-finisher pigs[J].Translational Animal Science, 2021, 5(4):txab202.
[49] CEMIN H S, CARPENTER C B, WOODWORTH J C, et al.Effects of zinc source and level on growth performance and carcass characteristics of finishing pigs[J].Translational Animal Science, 2019, 3(2):742-748.
[50] VILLAGOMEZ-ESTRADA S, PEREZ J F, VAN KUIJK S, et al.Effects of two zinc supplementation levels and two zinc and copper sources with different solubility characteristics on the growth performance, carcass characteristics and digestibility of growing-finishing pigs[J].Journal of Animal Physiology and Animal Nutrition (Berl), 2021, 105(1):59-71.
[51] BUFF C E, BOLLINGER D W, ELLERSIECK M R, et al.Comparison of growth performance and zinc absorption, retention, and excretion in weanling pigs fed diets supplemented with zinc-polysaccharide or zinc oxide[J].Journal of Animal Science, 2005, 83(10):2380-2386.
[52] WANG Y, TANG J W, MA W Q, et al.Dietary zinc glycine chelate on growth performance, tissue mineral concentrations, and serum enzyme activity in weanling piglets[J]. Biological Trace Elements Research, 2010, 133(3):325-334.
[53] 刘惠芳.微量元素锌对动物繁殖性能的影响[J].畜禽业, 2003, 7:31. LIU H F.Effects of micronutrient zinc on reproductive performance in animals[J].Livestock and Poultry Industry, 2003, 7:31.(in Chinese)
[54] SKALNY A V, ASCHNER M, TINKOV A A.Zinc[J].Advances in Food Nutriton Research, 2021, 96:251-310.
[55] GIACONE F, CONDORELLI R A, MONGIOI L M, et al.In vitro effects of zinc, D-aspartic acid, and coenzyme-Q10 on sperm function[J].Endocrine, 2017, 56(2):408-415.
[56] LI Z, LI Y, ZHOU X, et al.Preventive effects of supplemental dietary zinc on heat-induced damage in the epididymis of boars[J]. Journal of Thermal Biology, 2017, 64:58-66.
[57] PIPAN M Z, MRKUN J, STRAJN B J, et al.The influence of macro- and microelements in seminal plasma on diluted boar sperm quality[J].Acta Veterinaria Scandinavica, 2017, 59(1):11.
[58] ALLOUCHE-FITOUSSI D, BAKHSHI D, BREITBART H.Signaling pathways involved in human sperm hyperactivated motility stimulated by Zn²⁺[J].Molecular Reproduction and Development, 2019, 86(5):502-515.
[59] RIDLO M R, KIM G A, TAWEECHAIPAISANKUL A, et al.Zinc supplementation alleviates endoplasmic reticulum stress during porcine oocyte in vitro maturation by upregulating zinc transporters[J].Journal of Cellular Physiology, 2021, 236(4):2869-2880.
[60] BALDUIT A, MANGOGNA A, AGOSTINIS C, et al.Zinc oxide exerts anti-inflammatory properties on human placental cells[J].Nutrients, 2020, 12(6):1822.
[61] 王松林.几种微量元素对母猪繁殖性能的影响[J].饲料博览, 2021, 2:67-68. WANG S L.Effects of several microelements on reproductive performance of sow[J].Feed Review, 2021, 2:67-68.(in Chinese)
[62] BLAVI L, SOLA-ORIOL D, LLONCH P, et al.Management and feeding strategies in early life to increase piglet performance and welfare around weaning:A review[J].Animals (Basel), 2021, 11(2):302.
[63] HILL G M, MILLER E R, STOWE H D.Effect of dietary zinc levels on health and productivity of gilts and sows through two parities[J].Journal of Animal Science, 1983, 57(1):114-122.

Physiological Function of Micromineral Zinc and Its Application in Pig Breeding

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	WEI Mingbang, BIANBA Qiongda, XIAO Qingqing, DUAN Mengqi, CHAMBA Yangzom, SHANG Peng. Cloning,Bioinformatics and Expression Analysis of CDKN1B Gene in Tibetan Pigs [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2196-2206.
[2]	WANG Yangyang, QIN Shizhen, TANG Defu, SHAO Yuxin, SHI Zhaoguo, WANG Zheng, LI Xing, ZHAO Dongdong. Effects of Zinc, Lactobacillus on Immune and Antioxidant Function of Squabs Infected with Salmonella [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2276-2285.
[3]	ZHANG Fangwei, ZHANG Qi, LEI Liangliang, SUN Wusheng, ZHANG Di, ZHANG Yunpeng, ZHANG Jingbo, WANG Xiuquan, ZHANG Jing, ZHANG Shumin. Polymorphism of HBEGF Gene and Its Association with Reproductive Traits in Songliao Black Pigs [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2370-2379.
[4]	PAN Pengcheng, LEI Zongquan, LI Xian, HU Xiangyun, QIN Qiantao, QIN Zhaoxian, GUAN Zhihui, CHEN Baojian, XIE Bingkun. Bioinformatics Analysis,Eukaryotic Expression Vector Construction and Tissue Expression of MYL2 Gene in Luchuan Pigs [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 1796-1806.
[5]	LIU Hongrun, ZHU Siran, FENG Lingli, ZHANG Kun, YAN Gang, WANG Yubin, ZHANG Shuai, JIANG Shan, XU Di, LAN Ganqiu, LIANG Jing. Cloning,Bioinformatics Analysis and Tissue Expression Localization of CDO1 Gene in Large White Pigs [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1352-1363.
[6]	CHANG Yitong, ZHANG Wei, PENG Yinglin, CHEN Chen. Evolutionary Analysis,Target Gene Prediction and Tissue Expression Analysis of miR-192 [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(3): 882-892.
[7]	YIN Yi, LYU Yanqiu, CHEN Xuan, CAO Lipeng, ZHANG Junzheng, JIN Yi. Effects of Capacitation on Sperm Quality and Regulation of Acrosin Inhibitor Levels by Ubiquitin in Pigs [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(1): 174-185.
[8]	CHEN Chuanhe, LIU Jiali, ZHANG Lilan, ZHAO Ying, TAO Cong. Bioinformatics Analysis of Porcine SGK Family Genes and Their Expression in Porcine Adipose Tissues and Adipocytes [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(9): 3310-3320.
[9]	WO Yeqianli, GAO Duo, MA Fengtao, JIN Yuhang, LIU Zhuo, SUN Peng. Effects of Two Different Organic Zinc Sources Supplementation on Growth Performance and Zinc Metabolism of Newborn Heifers [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(9): 3382-3390.
[10]	YANG Man, LIU Hai, ZHANG Run, HU Ziping, NIU Naiqi, WANG Lixian, ZHANG Longchao. Association Analysis of Polymorphism of MYH3 and MYH13 Genes with Meat Quality Traits in Beijing Black Pigs [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(9): 3428-3437.
[11]	YU Peng, NIU Xiaoyu, DONG Ling, LU Mengqi, CHEN Yanhong, LI Fan, SONG Hui. Research Progress on the Role of lncRNA in Porcine Abortion-related Virus Infection [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(9): 3559-3568.
[12]	NIE Jingru, MA Li, YAN Dawei, DENG Jun, ZHANG Hao, ZHANG Bo, LIU Jinqiao, DONG Xinxing. Analysis of Differentially Expressed Genes and Regulation Pathways of Intramuscular Fat Deposition in Large Diqing Tibetan Pigs at Different Growth Stages [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(8): 2855-2868.
[13]	YU Zonggang, MA Haiming. Research Progress on Isolation and Culture of Porcine Skeletal Muscle Satellite Cells in vitro [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(8): 2931-2942.
[14]	YANG Tao, ZHANG Mingjie, XU Ran, ZHANG Han, ZHANG Mengmeng, WU Keliang. Study on Genetic Evaluation of Reproductive and Growth Traits in Pigs by BLUP Method [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(8): 2971-2981.
[15]	LI Wangjiao, PENG Xia, SONG Hui, DONG Wenjun, LI Xinyun, ZHAO Shuhong, MA Yunlong. Selection Signature Analysis Reveals the Key Genes Associated with the Convergence Traits Among Porcine Terminal Sire Populations [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(8): 2982-2991.