加味平胃口服液提取工艺研究

doi:10.16431/j.cnki.1671-7236.2022.06.041

Abstract

Abstract: 【Objective】 The study was aimed to determine the extraction process of Jiawei Pingwei oral liquid.【Method】 The L₉(3⁴) orthogonal test method was used to conduct in-depth research on the extraction process.The volatile oil of medicinal materials containing volatile oil was extracted, and the drug residue was mixed with other medicinal materials for decoction and extraction.In the extraction process of volatile oil, firstly, the particle size of decoction pieces was investigated and the appropriate size of decoction pieces was selected.On this basis, three factors were selected:Solvent volume (A), soaking time (B) and decocting time (C).Three levels were taken for each factor for orthogonal test.Taking the extraction amount of volatile oil as the evaluation index, the extraction process of volatile oil from Atractylodes macrocephala, Magnolia officinalis, tangerine peel, Aucklandia and Fructus aurantii in the prescription was explored and studied, and the process was verified for three times.In the process of water decocting and extracting, three factors were selected:Solvent times (A), decocting time (B) and extraction times (C), and three levels were taken for each factor for orthogonal test.Taking the content of naringin and the total alkali content of matrine (total content of matrine and oxymatrine) as evaluation indexes, the water decoction extraction process was explored and studied, and the process was verified for 3 times.【Result】 Particle size screening results of pieces showed that 1-2 cm pieces were more reasonable.The verification analysis showed that the factors affecting the extraction of volatile oil were decocting time (C) > soaking time (B) > solvent times (A).The extraction process of volatile oil was 8 times water and decocting for 10 h.The factors affecting the water decoction extraction were extraction times (C) > decocting time (B) > solvent times (A).The water decocting extraction process was 8 times water, decocted for 1.5 h, and extracted 3 times.【Conclusion】 This study obtained the specific extraction method and process of Jiawei Pingwei oral liquid through experimental verification.The process had high extraction efficiency, stable and reliable preparation process, could meet the process standard of mass production, and had important practical value.

Key words: orthogonal test; extraction process; volatile oil; naringin; matrine

CLC Number:

S853.7

CHEN Yuxiao, LI Huanjuan, XI Xiaohua, HAO Jie, ZHOU Degang, SI Hongbin. Study on Extraction Process of Jiawei Pingwei Oral Liquid[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(6): 2414-2422.

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Study on Extraction Process of Jiawei Pingwei Oral Liquid

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