Abstract: Lumpy skin disease causes permanent damage to the skin of infected animals and leads to serious symptoms such as reduction of milk production, growth retardation, infertility of male animals and pre-mature miscarriage of females. As a result, the disease poses an essential threat to economy. Currently, there are no specific antiviral treatments for the disease, and the use of safe and effective vaccine constitutes a major way to prevent and control the spread of the disease. Lumpy skin disease virus attenuated vaccines have been successfully used in the control in many countries. In addition, due to the high similarity of genome sequence in Sheeppox virus, attenuated vaccines of Goatpox virus, Goatpox virus and Sheeppox virus have also been used in the control of Lumpy skin disease virus. Lumpy skin disease virus codes a large number of genes, the current research results have not found that the gene deletion vaccine and subunit vaccine have good protective effect. Inactivated vaccines have shown encouraging results in laboratory studies in recent years, but further large-scale clinical trials are still needed to prove their effectiveness. Finally, as a kind of Poxvirus, Lumpy skin disease virus has been proved to be one of the effective vectors for expressing various pathogenic antigens. This article mainly discussed the current vaccines available for Lumpy skin disease virus, including the application, protection effect, research direction of attenuated vaccines, inactivated vaccines, gene-deleted vaccines, and subunit vaccines, so as to provide novel insights into the development of vaccines and therapeutics for Lumpy skin disease virus in the future.

Key words: lumpy skin disease; Capripoxvirus; vaccine; vector vaccine