犬脓皮病耐甲氧西林伪中间型葡萄球菌抗菌药耐药性及消毒剂抗性研究进展

doi:10.16431/j.cnki.1671-7236.2021.09.041

Abstract

Abstract: Canine pyoderma is a purulent skin disease caused by methicillin-resistant Staphylococcus pseudintermedius (MRSP) infection. Staphylococcus is a kind of bacteria that can infect both human and animals, and cause various suppurative diseases. Among them, MRSP as an animal derived Staphylococcus, can be a reservoir of drug-resistant genes and it can transmit drug-resistant genes to human beings via environmental factors or food chain. In recent years, the cases of skin diseases caused by MRSP have increased significantly which challenges infection control. In this paper, the drug resistance and disinfectant resistance of pathogenic bacteria of canine pyoderma were reviewed. In terms of the pathogenic mechanism of canine pyoderma, the mechanism of MRSP leading to infection by destroying the function of cellular immune system were summarized, the significant drug resistance and related drug resistance genes of MRSP in many areas were mainly described, such as mecA and cat genes. The resistance to disinfectants and its mechanism in MRSP, including efflux pump, were introduced. In order to avoid the common resistance interfering with the treatment, the relationship between the resistance to disinfectants and the resistance to antibiotics from the acquired resistance mediated by mobile genetic elements and inherent resistance depending on bacterial cell structure in pathogenic bacteria were systematically analyzed, in order to find a scientific and reasonable treatment for canine pyoderma, and provide reference and theoretical support for clinical medication of canine pyoderma.

Key words: canine pyoderma; methicillin-resistant Staphylococcus pseudintermedius (MRSP); drug resistance; disinfectant resistance; resistance mechanism

CLC Number:

S852.61⁺1

YUAN Weiyi, LIN Xiaofeng, ZHANG Yuhao, XIAO Jinnan, WANG Yan. Research Progress on Antimicrobial and Disinfectant Resistance of Methicillin-resistant Staphylococcus pseudintermedius in Canine Pyoderma[J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(9): 3483-3490.

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Research Progress on Antimicrobial and Disinfectant Resistance of Methicillin-resistant Staphylococcus pseudintermedius in Canine Pyoderma

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