去乙酰化酶3对线粒体功能和猪生长发育影响的研究进展

doi:10.16431/j.cnki.1671-7236.2019.09.008

Abstract

Abstract: Sirt3,a member of the Sirtuin family,has a high degree of deacetylase activity,which regulates the growth,aging,metabolism and other physiological processes of animals.Current research indicates that Sirt3 can activate superoxide dismutase,regulate tricarboxylic acid cycle and promote electron transport chain to eliminate intracellular reactive oxygen species (ROS),avoid oxidative damage of cells and damage of mitochondrial membrane potential,to affects apoptosis and autophagy;Sirt3 can slow down aging by regulating ROS and reducing the incidence of various degenerative diseases.In addition,the Sirt3 affects muscle development by various ways such as activating AMP-dependent protein kinase (AMPK).Studies on pigs showed that there were differences in meat quality such as muscle color and water loss rate of different Sirt3 mutants,and Sirt3 had an effect on fatty acid oxidation and ketone body formation.The study of the cattle Sirt3 protein,which has high homology to the pig Sirt3 protein,found that there were significant differences in the body length,body height and muscle fat content of different mutant Sirt3.The authors summarized the regulation mechanism of Sirt3 on mitochondrial energy metabolism and oxidative damage,and its effects on apoptosis,autophagy and aging.They also described partial physicochemical properties of Sirt3 protein of pig and the mechanism of its effects on pig growth and development,in order to explore the biological role of this gene in pig muscle and fat development and provide a theoretical basis for animal production improvement.

Key words: Sirt3; pig; mitochondrion; fat; muscle

CLC Number:

S828

XU Lei, PENG Yuehan, XU Jinman, JU Huiming. Advances in Studies on the Effects of Sirt3 on Mitochondrial Function and Porcine Growth[J]. China Animal Husbandry and Veterinary Medicine, 2019, 46(9): 2560-2566.

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Advances in Studies on the Effects of Sirt3 on Mitochondrial Function and Porcine Growth

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