复合微生态制剂、饲用抗生素对肉鸡生长性能、肠道菌群数量和免疫性能的影响

doi:10.16431/j.cnki.1671-7236.2018.08.022

Abstract

Abstract:

This trial was conducted to evaluate the effects of compound probiotics and antibiotics on growth performance,intestinal microflora and immune function of broilers.Six hundred one-day-old female broiler chickens were randomly divided into 5 groups with 6 replicates per group and 20 broilers per replicate.The broilers in groupⅠ were fed basal diet,and the basal diet+1.0‰ T3(compound probiotics),the basal diet+20 g/t colistin sulphate,the basal diet+50 g/t bacitracin zinc,the basal diet+50 g/t bacitracin zinc+10 g/t colistin sulphate were provided to the broilers in group Ⅱ,Ⅲ,Ⅳ and Ⅴ,respectively.The pre-trial period lasted for 3 days,and the experiment lasted for 35 days.The results showed as follows:Compared with group Ⅰ,Ⅲ,Ⅳ and Ⅴ,the average daily gain (ADG) at each trial stage,the number of Lactobacillus in cecal and rectal were significantly increased (P<0.05),while the feed gain ratio (F/G),the number of Escherichia coli in cecal and rectal were significantly decreased in T3 group.Compared with group Ⅰ,Ⅲ,Ⅳ and Ⅴ,the spleen index of the group treated with T3 increased 27.44%,40.27%,29.01% and 29.81% (P<0.05);The bursa of Fabricius index increased significantly by 12.82%,37.50%,33.33% and 38.95%,respectively (P<0.05);The content of serum endotoxin in T3 group was lower than that of group Ⅰ(P>0.05) and group Ⅲ (24.77%, P<0.05).Compared with the groupⅠ and Ⅲ,the content of secreted immunoglobulin A (sIgA) in T3 group was significantly increased by 32.37% and 25.79%(P<0.05).In conclusion,adding 1.0‰ T3 could improve the growth performance and intestinal flora,promote the development of spleen and bursa in broilers.And the role of increasing the content of sIgA in cecal contents,decreasing the content of serum endotoxin of 1.0‰ T3 was better than the use of 20 g/t of clostridium sulfate.

Key words: compound probiotics; antibiotics; broiler; growth performance; intestinal flora; immune function

CLC Number:

S816.7

YU Jiamin, CHE Zhen, QI Xiuye, XIE Quanxi, ZHENG Junhong, LIU Xuejiang, GU Wei, SHAN Baolong. Effects of Compound Probiotics and Antibiotics on Growth Performance, Intestinal Flora and Immune Function of Broilers[J]. , 2018, 45(8): 2219-2226.

References

[1] 肖宏德,肖运才,何熙贞,等.用益生菌制剂代替断奶仔猪饲粮中抗生素的研究[J].动物医学进展,2014,35(3):53-58.XIAO H D,XIAO Y C,HE X Z,et al.Study on antibiotics in diet of weaned piglets by probiotics preparation[J].Progress in Veterinary Medicine, 2014,35(3):53-58.(in chinese)
[2] 唐茂妍,陈旭东,张朝晖.硫酸黏杆菌素及其替代物在饲料中的应用进展[J].饲料与畜牧,2017,1:43-46.TANG M Y,CHEN X D,ZHANG Z H.Application progress of colistin sulfate and its substitutes in feed[J].Feed and Livestock Husbandry,2017,1:43-46.
[3] 谢全喜,亓秀晔,陈振,等.复合微生态制剂对断奶仔猪生长性能、腹泻率、免疫性能和肠道菌群的影响[J].动物营养学报,2017,29(3):850-858.XIE Q X,QI X Y,CHEN Z,et al.Effect of compound probiotics on growth performance,diarrhea rate,immune function and intestinal microflora in weaned piglets[J].Chinese Journal of Animal Nutrition,2017,29(3):850-858.(in Chinese)
[4] 贾聪慧,杨彩梅,曾新福,等.丁酸梭菌对肉鸡生长性能、抗氧化能力、免疫功能和血清生化指标的影响[J].动物营养学报,2016,28(3):908-915.JIA C H,YANG C M,ZENG X F,et al.Effects of Clostridium butyricum on growth performance,antioxidant capacity,immune function and serum biochemical indexes in broilers[J]. Chinese Journal of Animal Nutrition,2016,28(3):908-915.(in Chinese)
[5] 于卓腾,毛胜勇,朱伟云.微生态制剂和饲用抗生素对肉鸡盲肠VFA和微生物区系的影响[J].南京农业大学学报,2007,30(3):110-114.YU Z T,MAO S Y,ZHU W Y.Effect of probiotics and feed antibiotics on caecal VFA and microflora of broilers[J].Journal of Nanjing Agricultural University, 2007,30(3):110-114.(in Chinese)
[6] 张彩凤,王晓翠,张海军,等.乳酸菌和酵母菌复合制剂对肉仔鸡生长性能、屠宰性能和肠道健康的影响[J].动物营养学报,2017,29(4):1248-1256.ZHANG C F,WANG X C,ZHANG H J,et al.Effect of lactic acid bacteria and yeast compound preparation on growth performance,slaughter performance and gut health of broilers[J]. Chinese Journal of Animal Nutrition, 2017,29(4):1248-1256.(in Chinese)
[7] 谢全喜,崔诗法,徐海燕,等.复合微生态制剂与饲用抗生素对肉鸡生长性能、免疫性能和抗氧化指标的影响[J].动物营养学报,2012,24(7):1336-1344.XIE Q X,CUI S F,XU H Y,et al.Effect of compound probiotics and feed antibiotics on growth performance,immune function and antioxidation of broilers[J].Chinese Journal of Animal Nutrition, 2012,24(7):1336-1344.(in Chinese)
[8] 华洵璐,钱仁界,张宪中,等.芽孢杆菌复合制剂对断奶仔猪生长、腹泻和饲料消化率的影响[J].安徽农业科学,2015,43(3):166-170.HUA X L,QIAN R J,ZHANG X Z,et al.Effects of Bacillus coated preparation on growth,diarrhea and feed digestibility in weanling piglets[J].Journal of Anhui Agricultural Sciences, 2015,43(3):166-170.(in Chinese)
[9] MENG Q W,YAN L,AO X,et al.Influence of probi-otics in different energy and nutrient density diets on growth performance,nutrient digestibility,meat quality,and blood characteristics in growing-finishing pigs[J]. Journal of Animal Science,2010,88(10):3320-3326.
[10] 吴亨进,王明福,孙秋勇,等.复合微生态制剂对肉鸡生产性能及空气质量的影响[J].养殖与饲料,2008,5:81-84.WU H J,WANG M F,SUN Q Y,et al.Effect of compound probiotics on performance and air quality of broilers[J].Animals Breeding and Feed, 2008,5:81-84.(in Chinese)
[11] RIVAS A,FABRICANT J.Indications of immune depression in chickens infected with various strains of Marek's disease virus[J].Avian Diseases,1988,32(1):1-8.
[12] 陈佳力,陈代文,余冰,等.苯甲酸对断奶仔猪生长性能、器官指数和胃肠道内容物pH的影响[J].动物营养学报,2015,27(1):238-246.CHEN J L,CHEN D W,YU B,et al.Effects of benzoic acid on growth performance,organ index and pH of gastrointestinal contents in weaned piglets[J].Chinese Journal of Animal Nutrition, 2015,27(1):238-246.(in Chinese)
[13] MAROUFYANE E,KASIM A,HASHEMI S R,et al.Change in growth performance and liver function enzymes of broiler chickens challenged with infectious bursal disease virus to dietary supplementation of methionine and threonine[J].American Journal of Animal and Veterinary Sciences,2010,5(1):20-26.
[14] 李可,罗建杰,孟昆,等.益生菌对肉仔鸡生产性能、胴体性状、免疫功能和肉品质的影响[J].动物营养学报,2015,27(9):2903-2910.LI K,LUO J J,MENG K,et al.Effects of probiotics on broiler performance,carcass traits,immune function and meat quality[J]. Chinese Journal of Animal Nutrition, 2015,27(9):2903-2910.(in Chinese)
[15] 郭欣怡,张曼,韩飞,等.不同益生菌制剂对肉鸡生产性能、免疫功能和肠道菌群的影响[J].家畜生态学报,2016,37(11):79-83.GUO X Y,ZHANG M,HAN F,et al.Effects of different probiotics on production performance,immune function and intestinal flora in broilers[J]. Journal of Domestic Animal Ecology,2016,37(11):79-83.(in Chinese)
[16] PURCHIARONI F,TORTORA A,GABRIELLI M,et al.The role of intestinal microbiota and the immune system[J].European Review for Medical and Pharma-cological Sciences,201317(3):323-333.
[17] 元娜,陈奇,刘丛敏,等.复合微生态制剂对蛋种鸡舍内氨气浓度、养分吸收率及肠道菌群的影响[J].饲料工业,2010,31(20):42-45.YUAN N,CHEN Q,LIU C M,et al.Effect of compound probiotics on ammonia concentration,nutrient uptake and gut microbiota in laying hen house[J].Feed Industry,2010,31(20):42-45.(in Chinese)
[18] VINDEROLA G,MATAR C,PERDIGON G.Role of intestinal epithelial cells in immune effects mediated by gram-positive probiotic bacteria:Inolvement of toll-like receptors[J].Clinical and Diagnostic Laboratory Immunology,2005,12(9):1075-1084.
[19] 李丹,张建梅,程秀芳,等.饲用抗生素、微生态制剂对肉鸡机体内毒素、细胞因子的影响[J].饲料与畜牧,2013,9:39-41.LI D,ZHANG J M,CHENG X F,et al.Effects of feeding antibiotics and probiotics on toxins and cytokines in broilers[J].Feed and Livestock Husbandry,2013,9:39-41.(in Chinese)
[20] LLOYD M.Mucosal immunity[J].Pediatrics,2003,111(3):1595-1600.

Effects of Compound Probiotics and Antibiotics on Growth Performance, Intestinal Flora and Immune Function of Broilers

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