犬常见肿瘤流行病学调查及组织病理学诊断

doi:10.16431/j.cnki.1671-7236.2018.05.037

Abstract

Abstract:

To investigate the pathogenesis of canine tumors,71 cases of canine tumor from a pet hospital in Harbin area were collected from 2016 to 2017,the histopathological method was used for tumor diagnosis,then the varieties of species,gender,age,sites and diet of tumors were statically analyzed.The results showed that among the 71 confirmed cases,there were 28 cases malignant tumors,including 3 cases of squamous cell carcinoma,5 cases of basal cell carcinoma,14 cases of breast cancer,2 cases of lymphadenoma,1 case of nephroblastoma,spermatogonial cancer,germ cell carcinoma and invasive vascular myxoma, respectively.There were 43 cases of benign tumor,including 15 cases of benign breast tumor,10 cases of fibroma,5 cases of leiomyoma,3 cases of papilloma,and spermatogonial tumor,respectively,and 1 case of ameloblastoma,ceruminal adenoma,lipoma,nodular hyperplasia,sex cord stromal tumor,granular cell tumor and perianal adenoma,respectively.In the above cases,the mammary gland and the skin had a higher incidence.They accounted for 40.8% and 34.0% of all dogs,respectively.The age of the dogs was 1 to 16 years old,with an average age of tumor onset being 9.1 years,the tumor onset rate became higher after 7 years old.This finding indicated that the middle and old age groups were at high risk,but the number of young dogs with tumors was increasing.All breeds were susceptible to tumors.Mix dogs had the highest tumors incidence,followed by the poodle and pekingese,and most of the tumors being located in mammary glands.Diet mainly leftovers and meat rice type.They accounted for 39% and 30% all dogs,respectively.Among the breeds of dogs with tumor,hybrid dogs were the majority;The types of tumors were related to the sex of dogs and whether they were neuter,such as breast tumor occurred in the unsterilized old bitch.This study provided a reference for the epidemiology investigation and diagnosis of canine neoplasms and had some reference significance for the prevention and diagnosis of canine neoplasms.

Key words: dog; tumor; histopathology; epidemiology investigation; diagnosis

CLC Number:

S858.292

CHANG Hongjian, REN Xiaoli, ZHANG Pei, ZHAO Bingbing, XIAO Min, LI Yongqi, WANG Sen, WU Yuhong, LIU Na, LIU Yun. Epidemiological Investigation and Histopathological Diagnosis of Common Tumors in Dogs[J]. , 2018, 45(5): 1417-1425.

References

[1] 王洪斌.兽医外科学[M].第5版.北京:中国农业出版社,2011. WANG H B.Veterinary Surgery[M].5th edition.Beijing:Chinese Agricultural Press,2011.(in Chinese)
[2] ŠOŠTARIC'ZUCKERMANN I C,SEVERIN K,HOHŠTETER M,et al.Incidence and types of canine tumours in Croatia[J].Veterinarski Arhiv,2013,83(1):31-45.
[3] TODOROVA I.Prevalence and etiology of the most common malignant tumours in dogs and cats[J].Bulgarian Journal of Veterinary Medicine,2006,9(2):85-98.
[4] LIU B,ZHENG Y,SHAN Q,et al.Elastography by acoustic radiation force impulse technology for differentiation of benign and malignant breast lesions:A meta-analysis[J].Journal of Medical Ultrasonics,2016,43(1):47-55.
[5] 黄平华,李美霞,杨军,等.38例犬肿瘤的病理诊断及分析[J].动物医学进展,2014,12:178-181. HUANG P H,LI M X,YANG J,et al.Pathological diagnosis and analysis of 38 cases of canine tumors[J].Progress in Veterinary Medicine,2014,12:178-181.(in Chinese)
[6] GRUNTZIG K,GRAF R,BOO G,et al.Swiss canine cancer registry 1955-2008:Occurrence of the most common tumour diagnoses and influence of age,breed,body size,sex and neutering status on tumour development[J]. Journal of Comparative Pathology,2016,155(2-3):156-170.
[7] 闫妮娜.合肥地区犬肿瘤流行病学调查及临床诊断技术的研究[D].合肥:安徽农业大学,2013. YAN N N.Epidemiological investigation and research of clinical diagnostic technology of canine tumors in Hefei[D].Hefei:Anhui Agricultural University,2013.(in Chinese)
[8] 沈清霞,王亚辰,郭苓,等.南京地区宠物犬肿瘤临床病理学诊断与发病分析[J].畜牧与兽医,2017,49(1):103-109. SHEN Q X,WANG Y C,GUO L,et al.Clinic histopathological diagnosis and carcinogenic factors analyses of tumors in pet dogs in Nanjing area[J].Animal Husbandry & Veterinary Medicine,2017,49(1):103-109.(in Chinese)
[9] 冯士彬,闫妮娜,林根祥,等.肿瘤标志物在犬肿瘤性疾病诊断中的应用[J].畜牧与兽医,2015,47(9):98-100. FENG S B,YAN N N,LIN G X,et al.Application of tumor markers in the diagnosis of canine tumor diseases[J].Animal Husbandry & Veterinary Medicine,2015,47(9):98-100.(in Chinese)
[10] BURKS H,PASHOS N,Martin E,et al.Endocrine disruptors and the tumor microenvironment:A new paradigm in breast cancer biology[J].Molecular & Cellular Endocrinology,2016,457:13-19.
[11] 朱国,师福山,杨杨.2012年-2014年杭州地区宠物犬肿瘤调查[J].动物医学进展,2015,11:129-133. ZHU G,SHI F S,YANG Y.Investigation of pet dog tumor in Hangzhou area in 2012-2014[J].Progress in Veterinary Medicine,2015,11:129-133.(in Chinese)
[12] 刘清华,乔海莲,赵献军,等.西安地区宠物犬肿瘤疾病的流行病学分析[J].畜牧与兽医,2013,45(7):93-96. LIU Q H,QIAO H L,ZHAO X J,et al.Epidemiological analysis of tumor diseases in pet dogs in Xi'an area[J].Animal Husbandry & Veterinary Medicine,2013,45(7):93-96.(in Chinese)
[13] 王海丽,张福宏.犬颌下恶性纤维组织瘤的诊治[J].动物医学进展,2014,8:134-136. WANG H L,ZHANG F H.Diagnosis and treatment of submandibular malignant fibrous tumor in dogs[J].Progress in Veterinary Medicine,2014,8:134-136.(in Chinese)
[14] 刘春晖,杨蕾,孙艳争,等.北京地区犬肿瘤发生率调查[J].中国兽医杂志,2013,49(1):63-64. LIU C H,YANG L,SUN Y Z,et al.Investigation of canine tumor incidence in Beijing area[J].Chinese Jaurnal of Veterinary Medicine,2013,49(1):63-64.(in Chinese)
[15] MATOS A J,BAPTISTA C S,G RTNER M F,et al.Prognostic studies of canine and feline mammary tumours:The need for standardized procedures[J].Veterinary Journal,2012,193(1):24-31.
[16] KWON S C,YOO D Y,KO M,et al.Mammary gland tumors in a male Cocker Spaniel[J]. Acta Veterinaria Scandinavica,2017,59(1):20.
[17] BEAUVAIS W,CARDWELL J M,BRODBELT D C.The effect of neutering on the risk of mammary tumours in dogs——Systematic review[J].Journal of Small Animal Practice,2012,53(4):198-204.
[18] 王靖媛,吴乔兴,佘锐萍,等.44例宠物犬肿瘤病理诊断及分析[J].中国畜牧兽医,2017,44(3):935-940. WANG J Y,WU Q X,SHE R P,et al.Histopathological diagnosis and analysis of 44 cases of pet dogs tumors[J].China Animal Husbandry & Veterinary Medicine,2017,44(3):935-940.(in Chinese)
[19] 王彤光,陈谊,侯加法.犬乳腺肿瘤手术治疗及其预后的调查[J].中国畜牧兽医,2012,39(7):228-230. WANG T G,CHEN Y,HOU J F.Investigation of surgical treatment and prognosis of canine mammary tumor[J].China Animal Husbandry & Veterinary Medicine,2012,39(7):228-230.(in Chinese)
[20] ELKASAPY A.Surgical management and histopathological classification of the canine mammary gland cancers[J].Measurement Techniques,2015,26(10):806-809.
[21] 赵德明,刘环,立山晋,等.犬皮肤及乳腺肿瘤病例分析[J].中国兽医杂志,1996,1:15-16. ZHAO D M,LIU H,LI S J,et al.Canine skin and breast cancer case analysis China[J].Chinese Journal of Veterinary Medicine,1996,1:15-16.(in Chinese)
[22] 遇秀玲,姚华,胡冬梅,等.犬猫肿瘤病的病理诊断[A].中国畜牧兽医学会小动物医学分会第四次学术研讨会、中国畜牧兽医学会兽医外科学分会第十六次学术研讨会论文集(1)[C].2009. YU X L,YAO H,HU D M,et al.The pathological diagnosis of tumor disease in dogs and cats[A].The Fourth Academic Conference of the Small Animal Medicine Branch of China animal Husbandry and Veterinary Association and the Sixteenth Academic Conference of the Veterinary Surgery Branch of China Society of Animal Husbandry and Veterinary Medicine(1)[C].2009.(in Chinese)
[23] 陈艳云,孙艳争,董军,等.21例犬皮肤肥大细胞瘤病例分析[J].中国兽医杂志,2014,50(4):61-63. CHEN Y Y,SUN Y Z,DONG J,et al.Analysis of 21 cases of canine cutaneous mast cell tumor[J].Chinese Journal of Veterinary Medicine,2014,50(4):61-63.(in Chinese)
[24] 刘琨,陆洪光,曹煜.皮肤肥大细胞增生症的研究进展[J].中国皮肤性病学杂志,2010,24(8):763-765. LIU K,LU H G,CAO Y.Research progress of cutaneous mast cell hyperplasia[J].Chinese Journal of Dermatology and Pathology,2010,24(8):763-765.(in Chinese)
[25] D'ANGELO A R,VITA S,MARRUCHELLA G,et al.Canine testicular tumours:A retrospective investigation in Abruzzo and Molise,Italy[J]. Veterinaria Italiana,2012,48(3):335-339.
[26] 郝宗耀,叶元平,刘明,等.152例睾丸肿瘤的临床诊治分析[J].现代泌尿生殖肿瘤杂志,2013,5(3):139-142. HAO Z Y,YE Y P,LIU M,et al.Analysis of clinical diagnosis and treatment of testicular tumors in 152 cases[J].Journal of Modern Genitourinary Oncology,2013,5(3):139-142.(in Chinese)
[27] LIAO A T,CHU P Y,YEH L S,et al.A 12-year retrospective study of canine testicular tumors[J].Journal of Veterinary Medical Science,2009,71(7):919-923.

Epidemiological Investigation and Histopathological Diagnosis of Common Tumors in Dogs

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	XU Yuanyuan, ZHENG Haiying, YANG Chunyan, DENG Tingxian, HUANG Chenqian, FENG Chao, LU Xingrong, DUAN Anqin, MO Xia, MA Xiaoya, SHANG Jianghua. Effects of Inhibition of BMP/Smad Signaling Pathway on the Growth and Steroid Hormone Synthesis of Buffalo Ovarian Granulosa Cells [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2354-2362.
[2]	YU Xingang, YUAN Kaijian, MU Xuanru, WANG Hongcai, QI Nanshan, ZHANG Haoji. Research Progress on the Formation of Cyst Wall and Cyst Wall Proteins of Giardia [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 2061-2068.
[3]	XU Jiahui, XIE Jiaxin, JIANG Chengkun, ZHANG Sen, YAO Hua, ZHANG Hua. Application of Three-dimensional Reconstruction and 3D Printing Technology in Beagle Dog Liver Model Construction [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 2130-2138.
[4]	TANG Yu, YANG Yifeng, ZHANG Ying, XUE Hailong, FENG Huailiang, XU Baozeng. Cytological Study on Oocyte Maturation of Raccoon Dog [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1434-1443.
[5]	HE Yue, WANG Hui, CHEN Ruipeng, YU Zhixue, TANG Xiangfang, GUO Yuming, XIONG Benhai. Research Progress on Optical and Electrochemical Biosensors for the Diagnosis of Important Diseases in Dairy Cows [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 827-837.
[6]	WANG Yue, ZHENG Yunxi, XU Songsong, XIANG Guangming, LI Hua, WANG Nan, FENG Zheng, LI Kui, MU Yulian. Regulation of Wip1 Gene on Animal Reproduction and Immunity [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(9): 3500-3507.
[7]	ZHANG Qingxun, ZHONG Zhenyu, GUO Qingyun, HE Hongxuan, BAI Jiade. Recent Advances of Pathogens Detection Based on CRISPR-Cas System [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(8): 3190-3199.
[8]	LIANG Yingxin, CHEN Zejia, LI Jichao, CUI Xiaoxiao, FENG Qianqi, LI Shoujun, CHEN Aolei. Investigation on the Infection of Equine Intestinal Parasite in Partial Cities in Guangdong Province [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(7): 2725-2734.
[9]	WANG Shuang, LIU Xingyao, JIA Haotian, LIU Yun. Alleviative Effect of Hydrogen Sulfide on Cisplatin-induced Kidney Oxidative Damage and Inflammation in Dogs [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(6): 2376-2384.
[10]	HUANG Xiaohang, LI Shiyi, LI Yongxia, LI Mengrui, HE Jinyu, ZHANG Long, LIU Daoquan, JIANG Heji, HUANG Zhijian, YIN Guangwen. Clinical Case Study of Toad Infected with Sphaerirostris lanceoides [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(6): 2423-2430.
[11]	ZHAO Tianrui, SHAO Jinhua, WANG Chaohao, YAN Rui, LEI Yifei, LIU Xiaoya, HU Changmin. Isolation and Identification of Skin Pathogenic Bacteria from Dogs and Cats and Analysis of Antibacterial Effect of Natural Products [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(4): 1556-1567.
[12]	WEI Yunfang, LI Feixiang, Xing Yun, Huang Qingguo, LI Judong, WAN Jiusheng, CHEN Fangliang. Study on Cloning, Bioinformatics Analysis and Spatio-temporal Expression of IGF2 Gene in Kunming Dogs [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(3): 866-875.
[13]	XIE Zimin, ZENG Fancong, FU Yuming, JIANG Hanyu, YANG Huihu, KE Junhong, LUO Rui, LIANG Zhaoping, ZHANG Xuelian, HUANG Shujian. Study on Pathogenicity of 4 Strain of Subgroup Ⅰ Fowl Adenovirus Isolates to SPF Chicks [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(3): 1032-1040.
[14]	MING Yuexiang, WANG Weixin, YANG Xiaoyu, ZHANG Di, LIN Jiahao. Research Progress on Canine Pruritic Skin Diseases [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(3): 1189-1199.
[15]	TIAN Yangqing, WANG Yayuan, ANG Yanfen, YAN Han, LIU Xin, YAN Yulin. Research Progress on Therapeutic Mechanism and Application of Canine Hematopoietic Stem Cell Transplantation [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(2): 791-799.