犬瘙痒性皮肤病研究进展

doi:10.16431/j.cnki.1671-7236.2022.03.042

Abstract

Abstract: Pruritus is one of the typical clinical symptoms of dermatosis in canine, which is usually accompanied by other skin symptoms such as alopecia and erythema.The pruritus not only troubles the animal itself, but also affects the life quality of the pet-owner.The mechanism of itching is complex.At present, there have been a large number of clinical and basic researches on pruritus diseases in humans and dogs at home and abroad, revealing the relationship between pruritus and the neuroimmune system, and introducing the concept of "pruritus-scratching" cycle, and indicating that the independent effects of the immune system, the skin barrier and the nervous system and the interaction between them are the key factors in pruritus, and any problem in them can start the "pruritus-scratching" cycle.The clinical etiology of pruritic skin diseases in canine is complex.Refering to the the classification of pruritus which was proposed by International Forum for the Study of Itch in 2007, the diseases that cause pruritus are divided into six categories correspondingly according to the etiology, and the diseases which can cause dermatologic pruritus are divided infectious diseases, allergic diseases, neoplastic diseases, and the most important in clinic is canine allergic pruritus.The diagnostic methods and differential diagnosis of canine pruritic skin diseases are diverse, and the information collected from various aspects of the sick dogs are needed.The differential diagnosis are carried out step by step in a certain sequence.There are still problems in the treatment of canine pruritic skin diseases, such as long treatment cycles and easy recurrence of the disease.At present, the commonly used western medicine drugs have disadvantages such as large side effects, single target and high price, and the Chinese medicine prescription which has complex components has many effective components, so it can treat pruritus with complex mechanism through multiple channels and multiple approaches, which has advantages and broad prospects in the treatment of canine pruritic skin disease.This article reviewed the latest pruritus mechanism, classification and diagnosis of canine pruritic skin diseases, and Chinese and Western medicine treatment ideas, so as to provide a reference for the diagnosis and treatment of clinical pruritus-related diseases in small animals.

Key words: canine; pruritus; mechanism; classification; diagnosis

CLC Number:

S858.292

MING Yuexiang, WANG Weixin, YANG Xiaoyu, ZHANG Di, LIN Jiahao. Research Progress on Canine Pruritic Skin Diseases[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(3): 1189-1199.

References

[1] BENSIGNOR E, MARIGNAC G, CROSAZ O, et al.Pruritus in dogs[J].Veterinary Dermatology, 2013, 24(2):292.
[2] HILL P B, LO A, EDEN C A N, et al.Survey of the prevalence, diagnosis and treatment of dermatological conditions in small animals in general practice[J].The Veterinary Record, 2006, 158(16):533-539.
[3] SUN Y, CHEN Z.A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord[J].Nature, 2007, 448(7154):700-703.
[4] WANG F, KIM B S.Itch:A paradigm of neuroimmune crosstalk[J].Immunity, 2020, 52(5):753-766.
[5] ROSS S E.Pain and itch:Insights into the neural circuits of aversive somatosensation in health and disease[J].Current Opinion in Neurobiology, 2011, 21(6):880-887.
[6] MACK M R, KIM B S.The itch-scratch cycle:A neuroimmune perspective[J].Trends in Immunology, 2018, 39(12):980-991.
[7] SILVERBERG N B, SILVERBERG J I.Inside out or outside in:Does atopic dermatitis disrupt barrier function or does disruption of barrier function trigger atopic dermatitis[J].Cutis, 2015, 96(6):359-361.
[8] IRVINE A D, MCLEAN W H I, LEUNG D Y M.Filaggrin mutations associated with skin and allergic diseases[J].The New England Journal of Medicine, 2011, 365(14):1315-1327.
[9] 杨雁, 唐宗湘.痒觉信号通路与相关受体研究进展[J].生物化学与生物物理进展, 2013, 40(3):209-215. YANG Y, TANG Z X.Research progress of itch signal pathways and related receptors[J].Progress in Biochemistry and Biophysics, 2013, 40(3):209-215.(in Chinese)
[10] YANG T B, KIM B S.Pruritus in allergy and immunology[J].The Journal of Allergy and Clinical Immunology, 2019, 144(2):353-360.
[11] 邱阳, 蔡涛.瞬时受体电位A1在痒觉传导中的作用[J].临床皮肤科杂志, 2020, 49(9):573-576. QIU Y, CAI T.Roles of the ion channel TRPA1 in itch pathway[J].Journal of Clinical Dermatology, 2020, 49(9):573-576.(in Chinese)
[12] 郭晶晶, 李桂林.TRP离子通道在瘙痒中的作用及机制研究进展[J].中国药理学通报, 2019, 35(3):301-305. GUO J J, LI G L.Role and mechanism of TRP ion channels in pruritus[J].Chinese Pharmacological Bulletin, 2019, 35(3):301-305.(in Chinese)
[13] 王德.脊髓GRPR和NPRA在过敏性接触性皮炎慢性瘙痒的机制研究[D].广州:广州医科大学, 2020. WANG D.The mechanism of spinal GRPR and NPRA in chronic pruritus of allergic contact dermatitis[D].Guangzhou:Guangzhou Medical University, 2020.(in Chinese)
[14] ASAHINA R, MAEDA S.A review of the roles of keratinocyte-derived cytokines and chemokines in the pathogenesis of atopic dermatitis in humans and dogs[J].Veterinary Dermatology, 2017, 28(1):15-16.
[15] ASAHINA R, NISHIDA H, KAMISHINA H, et al.Expression of IL-33 in chronic lesional skin of canine atopic dermatitis[J].Veterinary Dermatology, 2018, 29(3):246-291.
[16] SIISKONEN H, HARVIMA I.Mast cells and sensory nerves contribute to neurogenic inflammation and pruritus in chronic skin inflammation[J].Frontiers in Cellular Neuroscience, 2019, 13:422.
[17] SALIMI M, BARLOW J L, SAUNDERS S P, et al.A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis[J].The Journal of Experimental Medicine, 2013, 210(13):2939-2950.
[18] BRANDT E B, SIVAPRASAD U.Th2 cytokines and atopic dermatitis[J].Journal of Clinical & Cellular Immunology, 2011, 2(3).
[19] OETJEN L K, MACK M R, FENG J, et al.Sensory neurons co-opt classical immune signaling pathways to mediate chronic itch[J].Cell, 2017, 171(1):217-228.
[20] ZHAO Z, HUO F, JEFFRY J, et al.Chronic itch development in sensory neurons requires BRAF signaling pathways[J].The Journal of Clinical Investigation, 2013, 123(11):4769-4780.
[21] OLIVRY T, BÄUMER W.Atopic itch in dogs:Pharmacology and modeling[J].Handbook of Experimental Pharmacology, 2015, 226:357-369.
[22] SCHMEITZEL L P.Cheyletiellosis and scabies[J].The Veterinary Clinics of North America.Small Animal Practice, 1988, 18(5):1069-1076.
[23] NWUFOH O C, SADIQ A N, EMIKPE B O.The seroprevalence of Sarcoptes scabiei var. canis and its associated risk factors in dogs in Ibadan, Southwest Nigeria[J].Journal of Immunoassay & Immunochemistry, 2019, 40(5):473-484.
[24] SIVAJOTHI S, SUDHAKARA REDDY B, RAYULU V C.Demodicosis caused by Demodex canis and Demodex cornei in dogs[J].Journal of Parasitic Diseases, 2015, 39(4):673-676.
[25] THODAY K L.Canine pruritus:An approach to diagnosis.Stage Ⅱ.Infestations and infections[J].The Journal of Small Animal Practice, 1980, 21(8):449-458.
[26] DWORECKA-KASZAK B, BIEGAŃSKA M J, DABROWSKA I.Occurrence of various pathogenic and opportunistic fungi in skin diseases of domestic animals:A retrospective study[J].BMC Veterinary Research, 2020, 16:248.
[27] BOEHM T M S A, MUELLER R S.Dermatophytosis in dogs and cats-An update[J].Tierarztliche Praxis.Ausgabe K, Kleintiere/Heimtiere, 2019, 47(4):257-268.
[28] OUTERBRIDGE C A.Mycologic disorders of the skin[J].Clinical Techniques in Small Animal Practice, 2006, 21(3):128-134.
[29] NAGATA M.Malassezia and its presumed association with skin diseases in dogs[J].Medical Mycology Journal, 2013, 54(1):45-47.
[30] GUILLOT J, BOND R.Malassezia yeasts in veterinary dermatology:An updated overview[J].Frontiers in Cellular and Infection Microbiology, 2020, 10:79.
[31] AVSEVER M L, POLAT S H, AMKERTEN, et al.First isolation of Alternaria alternata from a dog in Turkey[J].Veteriner Fakültesi Dergisi, 2017, 64(2):137-139.
[32] DEDOLA C, STUART A P G, RIDYARD A E, et al.Cutaneous Alternaria infectoria infection in a dog in association with therapeutic immunosuppression for the management of immune-mediated haemolytic anaemia[J].Veterinary Dermatology, 2010, 21(6):626-634.
[33] LYNCH S A, HELBIG K J.The complex diseases of Staphylococcus pseudintermedius in canines:Where to next?[J].Veterinary Sciences, 2021, 8(1):11.
[34] PRIYANTHA R, GAUNT M C, RUBIN J E.Antimicrobial susceptibility of Staphylococcus pseudintermedius colonizing healthy dogs in Saskatoon, Canada[J].The Canadian Veterinary Journal, 2016, 57(1):65-69.
[35] BLOOM P.Canine superficial bacterial folliculitis:Current understanding of its etiology, diagnosis and treatment[J].The Veterinary Journal, 2014, 199(2):217-222.
[36] BRIERLEY S M.Food for thought about the immune drivers of gut pain[J].Nature, 2021, 590(7844):41-43.
[37] LOEFFLER A, LLOYD D H.What has changed in canine pyoderma? A narrative review[J].Veterinary Journal (London, England:1997), 2018, 235:73-82.
[38] GORTEL K.Recognizing pyoderma:More difficult than it may seem[J].The Veterinary Clinics of North America.Small Animal Practice, 2013, 43(1):1-18.
[39] GONZÁLEZ-DOMÍNGUEZ M S, CARVAJAL H D, CALLE-ECHEVERRI D A, et al.Molecular detection and characterization of the mecA and nuc genes from Staphylococcus species (S.aureus, S.pseudintermedius, and S.schleiferi) isolated from dogs suffering superficial pyoderma and their antimicrobial resistance profiles[J].Frontiers in Veterinary Science, 2020, 7:376.
[40] ROSSER E J J.German shepherd dog pyoderma[J].The Veterinary Clinics of North America.Small Animal Practice, 2006, 36(1):203-211.
[41] CAMPBELL J.Allergic skin diseases in dogs and cats[M].Hoboken:John Wiley & Sons, Ltd, 2019.
[42] BRUET V, BOURDEAU P J, ROUSSEL A, et al.Characterization of pruritus in canine atopic dermatitis, flea bite hypersensitivity and flea infestation and its role in diagnosis[J].Veterinary Dermatology, 2012, 23(6):487-493.
[43] GASCHEN F P, MERCHANT S R.Adverse food reactions in dogs and cats[J].The Veterinary Clinics of North America.Small Animal Practice, 2011, 41(2):361-379.
[44] PALI-SCHÖLL I, DE LUCIA M, JACKSON H, et al.Comparing immediate-type food allergy in humans and companion animals-revealing unmet needs[J].Allergy, 2017, 72(11):1643-1656.
[45] YU W, FREELAND D M H, NADEAU K C.Food allergy:Immune mechanisms, diagnosis and immunotherapy[J].Nature Reviews.Immunology, 2016, 16(12):751-765.
[46] MUELLER R S, OLIVRY T.Critically appraised topic on adverse food reactions of companion animals (4):Can we diagnose adverse food reactions in dogs and cats with in vivo or in vitro tests?[J].BMC Veterinary Research, 2017, 13(1):275.
[47] OLIVRY T, MUELLE R S.Critically appraised topic on adverse food reactions of companion animals (7):Signalment and cutaneous manifestations of dogs and cats with adverse food reactions[J].BMC Veterinary Research, 2019, 15(1):140.
[48] MUELLER R S, OLIVRY T, PRÉLAUD P.Critically appraised topic on adverse food reactions of companion animals (2):Common food allergen sources in dogs and cats[J].BMC Veterinary Research, 2016, 12(1):9.
[49] UDRAITE VOVK L, WATSON A, DODDS W J, et al.Testing for food-specific antibodies in saliva and blood of food allergic and healthy dogs[J].Veterinary Journal (London, England:1997), 2019, 245:1-6.
[50] GEDON N K Y, MUELLER R S.Atopic dermatitis in cats and dogs:A difficult disease for animals and owners[J].Clinical and Translational Allergy, 2018, 8(1):41.
[51] MARSELLA R.Advances in our understanding of canine atopic dermatitis[J].Veterinary Dermatology, 2021.
[52] SCHAMBER P, SCHWAB-RICHARDS R, BAUER-SACHS S, et al.Gene expression in the skin of dogs sensitized to the house dust mite Dermatophagoides farinae[J].G3 (Bethesda), 2014, 4(10):1787-1795.
[53] TENGVALL K, KIERCZAK M, BERGVALL K, et al.Genome-wide analysis in German shepherd dogs reveals association of a locus on CFA 27 with atopic dermatitis[J].PLoS Genetics, 2013, 9(5):e1003475.
[54] AGLER C S, FRIEDENBERG S, OLIVRY T, et al.Genome-wide association analysis in West Highland White Terriers with atopic dermatitis[J].Veterinary Immunology and Immunopathology, 2019, 209:1-6.
[55] NUTTALL T J, MARSELLA R, ROSENBAUM M R, et al.Update on pathogenesis, diagnosis, and treatment of atopic dermatitis in dogs[J].Journal of the American Veterinary Medical Association, 2019, 254(11):1291-1300.
[56] CHAUDHARY S K, SINGH S K, KUMARI P, et al.Alterations in circulating concentrations of IL-17, IL-31 and total IgE in dogs with atopic dermatitis[J].Veterinary Dermatology, 2019, 30(5):383-e114.
[57] KOSTNER L, ANZENGRUBER F, GUILLOD C, et al.Allergic contact dermatitis[J].Immunology and Allergy Clinics of North America, 2017, 37(1):141-152.
[58] SINGLETON D A, MCGARRY J, TORRES J R, et al.Small animal disease surveillance 2019:Pruritus, pharmacosurveillance, skin tumours and flea infestations[J].The Veterinary Record, 2019, 185(15):470-475.
[59] KIUPEL M, CAMUS M.Diagnosis and prognosis of canine cutaneous mast cell tumors[J].The Veterinary Clinics of North America.Small Animal Practice, 2019, 49(5):819-836.
[60] ZAMARIAN V, CATOZZI C, CUSCÓ A, et al.Characterization of skin surface and dermal microbiota in dogs with mast cell tumor[J].Scientific Reports, 2020, 10(1):12634.
[61] MINESHIGE T, KAWARAI S, YAUCHI T, et al.Cutaneous epitheliotropic T-cell lymphoma with systemic dissemination in a dog[J].Journal of Veterinary Diagnostic Investigation, 2016, 28(3):327-331.
[62] WAISGLASS S E, GILLICK A, COCKSHUTT J, et al.Pruritus possibly associated with a portosystemic shunt in a bichon frise puppy[J].Canadian Veterinary Journal, 2006, 47(11):1109-1111.
[63] HENSEL P, SANTORO D, FAVROT C, et al.Canine atopic dermatitis:Detailed guidelines for diagnosis and allergen identification[J].BMC Veterinary Research, 2015, 11:196.
[64] FLANAGAN S, SCHICK A, LEWIS T P.A pilot study to identify perceived barrier and motivating factors of primary veterinarians in the USA for specialty referral and management of atopic dermatitis with allergen-specific immunotherapy[J].Veterinary Dermatology, 2020, 31(5):371-398.
[65] JACKSON H A, JACKSON M W, COBLENTZ L, et al.Evaluation of the clinical and allergen specific serum immunoglobulin E responses to oral challenge with cornstarch, corn, soy and a soy hydrolysate diet in dogs with spontaneous food allergy[J].Veterinary Dermatology, 2003, 14(4):181-187.
[66] OLIVRY T, SARIDOMICHELAKIS M.Evidence-based guidelines for anti-allergic drug withdrawal times before allergen-specific intradermal and IgE serological tests in dogs[J].Veterinary Dermatology, 2013, 24(2):225-249.
[67] MARSELLA R, AHRENS K, WILKES R, et al.Comparison of various treatment options for canine atopic dermatitis:A blinded, randomized, controlled study in a colony of research atopic beagle dogs[J].Veterinary Dermatology, 2020, 31:269-284.
[68] SARIDOMICHELAKIS M N, OLIVRY T.An update on the treatment of canine atopic dermatitis[J].Veterinary Journal (London, England:1997), 2016, 207:29-37.
[69] HSIAO Y, CHEN C, WILLEMSE T.Effects of cetirizine in dogs with chronic atopic dermatitis:A randomized, double blind, placebo-controlled trial[J].Journal of Veterinary Science, 2016, 17(4):549-553.
[70] 宋玮, 黄慧敏, 余倩颖, 等.基于"症状病机方证"分型辨治皮肤瘙痒症[J].中医杂志, 2019, 60(18):1607-1610. SONG W, HUANG H M, YU Q Y, et al.Diagnosis and treatment of pruritus based on classification of ‘symptoms, pathogenesis, formulas and syndrome’[J].Journal of Traditional Chinese Medicine, 2019, 60(18):1607-1610.(in Chinese)
[71] 黄蓓, 万君晗, 吴永秋, 等.皮肤瘙痒的发生机制及治疗的中药成分研究进展[J].海峡药学, 2018, 30(12):1-6. HUANG B, WAN J H, WU Y Q, et al.Research progress of the mechanism of skin itchiness and components of traditional Chinese medicine for treatment[J].Strait Pharmaceutical Journal, 2018, 30(12):1-6.(in Chinese)
[72] WANG J, ZHANG Y, WANG J, et al.Paeoniflorin inhibits MRGPRX2-mediated pseudo-allergic reaction via calcium signaling pathway[J].Phytotherapy Research, 2020, 34(2):401-408.
[73] WANG Z, WANG S, KUANG Y, et al.A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis[J].Pharmaceutical Biology, 2018, 56(1):465-484.

Research Progress on Canine Pruritic Skin Diseases

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	SONG Yue, SU Shengjie, ZHANG Fan, BAI Fan, DAI Lingli, WANG Na, WANG Dawei, YANG Qianwen, ZHAO Shihua, ZHANG Yuemei. Prokaryotic Expression and Polyclonal Antibody Preparation of Mannheimia haemolytica Truncated Leukotoxin [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2479-2486.
[2]	ZHANG Jingyi, CHEN Li, HUANG Siyang, CHEN Xiang, LIU Zongping, TONG Xishuai. Research Progress on Pathogenic Characteristics and Pathogenicity of Ehrlichia canis [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 2023-2031.
[3]	YU Xingang, YUAN Kaijian, MU Xuanru, WANG Hongcai, QI Nanshan, ZHANG Haoji. Research Progress on the Formation of Cyst Wall and Cyst Wall Proteins of Giardia [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 2061-2068.
[4]	XU Chenghui, ZHANG Xumei, YANG Tong, LI Jiahui, SUN Yawei, SHI Huijun, FU Qiang, YANG Li. Molecular Mechanism of Leonurine in the Treatment of Intestinal Inflammation Based on Network Pharmacology and Molecular Docking [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 2103-2113.
[5]	CHEN Tianbao, WANG Yani, LIU Baoling, WANG Gang, WANG Xiaohu, LIU Xuhui, CAI Rujian, HE Dongsheng. Research Progress on the Anti-Porcine Reproductive and Respiratory Syndrome Virus Effect and Mechanism of Traditional Chinese Medicine [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 2114-2129.
[6]	GUO Bingyu, LI Li, LI Chen, KONG Xianghui. Role and Molecular Mechanism of Mpeg1 in Pathogen Clearance [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1584-1592.
[7]	YAO Jiawei, HUANG Yujie, CHEN Zhisheng, WANG Bingyun, ZHANG Hui. Immunomodulatory Effects of Dimethyl Alpha-ketoglutarate Pretreatment on Canine Adipose-derived Mesenchymal Stem Cells [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1642-1652.
[8]	DOU Jiahong, WANG Ziying, YANG Juan, ZHOU Weiwei, ZHANG Tongcun, HE Hongpeng, DAI Xiaofeng, LI Xiumei. Analysis of the Active Ingredients and Mechanism of Radix Paeoniae Rubra Antioxidative Stress Based on Network Pharmacology and Molecular Docking [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(3): 1229-1240.
[9]	QIN Zhiyun, JIANG Huaizhi. An Overview of Research on Skin Hair Follicle Development and Regulatory Mechanism in Sheep During the Fetal Period [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 638-646.
[10]	HAN Guorui, XIAO Xiaoyue, ZHANG Yang, LI Yanhua, CHEN Xueying, WANG Xiumin, QIN Junjie, LIU Yanyan. Mechanism of Gui Qi Yimu Oral Liquid in the Treatment of Sus scrofa Qi and Blood Two Deficiency Syndrome Based on Network Pharmacology and Molecular Docking [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 722-733.
[11]	MENG Yingwen, LI Yuehua, SHA Zhou, LI Chenyu, GONG Youquan, DONG Yaqin, WEI Rong, ZOU Fengcai, NI Bo. Screening of the Natural Products Against Senecavirus A and Study on Its Mechanism of Antagonism [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 734-744.
[12]	WANG Wei, LI Chunzhu, WANG Shasha, SANG Rui, GE Bingjie, LI Chunting, ZHAO Xin, LIU Xinman, YU Minghong, ZHANG Xuemei. Study on the Protective Mechanism of Traditional Chinese Medicine Combined with Probiotics on Diarrhea Caused by E.coli in Mice [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 779-788.
[13]	LIU Bo, LI Meilin, LIU Xu, LIANG Shuangying, MU Baolong, ZHAO Wenting, GE Yansong. Effects of Adipose-derived Stem Cell Conditioned Medium Alleviates Oxidative Stress Injury Induced by Sodium Taurocholate and Trypsin [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 798-806.
[14]	HE Yue, WANG Hui, CHEN Ruipeng, YU Zhixue, TANG Xiangfang, GUO Yuming, XIONG Benhai. Research Progress on Optical and Electrochemical Biosensors for the Diagnosis of Important Diseases in Dairy Cows [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 827-837.
[15]	SONG Peijia, JIN Yipeng, LIN Degui, LIN Jiahao. Clinical Research Progress on Canine Periodontal Diseases [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 838-845.