菌落突变株与细菌适应性生存关系研究进展

doi:10.16431/j.cnki.1671-7236.2017.11.027

Abstract

Abstract:

Small colony variants (SCVs) have been shown to be part of the regular growth cycle, which are highly dynamic or stable and can be selected during various harsh conditions. The features of SCVs include slow growth, colony morphology irregular and biochemical characteristics abnormal, making the separation and identification of SCVs into trouble. SCVs can cause chronic persistent infection, but not lead to strong immune response to host. Furthermore, SCVs are serious resistant to antibacterials normally. In this paper, we introduce the phenotype classification of SCVs, the relationship with the host's immune response and the effects of antibacterials on SCVs, which will provide theoretical support for further research of SCVs.

Key words: small colony variants; phenotype; immune response; antibiotics resistance

CLC Number:

R446.5

GAO Xiang, GUO Yu-ru, YANG Jie, HUANG Cheng-cheng, TIAN Chun-lian, HONG Wei, LIU Ming-chun. Research Progress on Adaptive Survival Relationship Between Small Colony Variants and Bacteria[J]. , 2017, 44(11): 3300-3305.

References

[1] Alkasir R, Liu X, Zahra M, et al. Characteristics of Staphylococcus aureus small colony variant and its parent strain isolated from chronic mastitis at a dairy farm in Beijing, China[J]. Microb Drug Resist, 2013, 19(2):138-145.
[2] Pakasticali N, Kaya G, Senel U, et al. Prevalence, antibiotic and pulsed-field gel electrophoresis patterns of Staphylococcus aureus small colony variants in cystic fibrosis patients[J]. Southeast Asian J Trop Med Public Health, 2016, 47(3):475-484.
[3] Ogihara S, Saito R, Sawabe E, et al. First Japanese case of infectious endocarditis due to Enterococcus faecalis small colony variants[J]. J Infect and Chemother, 2016, 22(10):716-719.
[4] 刘修权, 曲伟杰, 高健, 等. 金黄色葡萄球菌小菌落突变株研究进展[J]. 中国兽医杂志, 2011, 47(3):54-57.
[5] Masoud-Landgraf L, Zarfel G, Kaschnigg T, et al. Analysis and characterization of Staphylococcus aureus small colony variants isolated from cystic fibrosis patients in Austria[J]. Curr Microbiol, 2016, 72(5):606-611.
[6] Hirschhausen N, Block D, Bianconi I, et al.Extended Staphylococcus aureus persistence in cystic fibrosis is associated with bacterial adaptation[J]. Int J Med Microbiol, 2013, 303(8):685-692.
[7] Li W, Li Y, Wu Y, et al. Phenotypic and genetic changes in the life cycle of small colony variants of Salmonella enterica serotype Typhimurium induced by streptomycin[J]. Ann Clin Microbiol Antimicrob, 2016, 15(1):37.
[8] Johns B E, Purdy K J, Tucker N P, et al. Phenotypic and genotypic characteristics of small colony variants and their role in chronic infection[J]. Microbiol Insights, 2015, 8:15-23.
[9] Santos V, Hirshfield I. The physiological and molecular characterization of a small colony variant of Escherichia coli and its phenotypic rescue[J]. PLoS One, 2016, 11(6):e0157578.
[10] Beaume M, Hernandez D, Docquier M, et al. Orientation and expression of methicillin-resistant Staphylococcus aureus small RNAs by direct multiplexed measurements using the nCounter of NanoString technology[J]. Microbiol Methods, 2011, 84(2):327-334.
[11] Curtis T D, Gram L, Knudsen G M. The small colony variant of Listeria monocytogenes is more tolerant to antibiotics and has altered survival in RAW 264.7 murine macrophages[J]. Front Microbiol, 2016, 7:1056.
[12] Vestergaard M, Paulander W, Leng B, et al. Novel pathways for ameliorating the fitness cost of gentamicin resistant small colony variants[J]. Front Microbiol, 2016,7:1866.
[13] 何娟梅, 朱国强. 小菌落突变株:一种利于持续复发性感染的细菌致病形[J]. 生物技术通讯, 2009, 20(3):388-392.
[14] Yagci S, Hascelik G, Dogru D, et al. Prevalence and genetic diversity of Staphylococcus aureus small-colony variants in cystic fibrosis patients[J]. Clin Microbiol and Infect, 2013, 19(1):77-84.
[15] Gomez-Gonzalez C, Acosta J, Villa J, et al. Clinical and molecular characteristics of infections with CO₂-dependent small-colony variants of Staphylococcus aureus[J]. J Clin Microbiol, 2010, 48(8):2878-2884.
[16] Bhattacharyya S, Jaiswal N K, Kumar M, et al. Breast abscess in a case of duct atresia caused by CO₂-auxotrophic small colony variants of Staphylococcus aureus:Case report and review of literature[J]. J Nat Sci Biol Med, 2015, 6(2):475-476.
[17] 朱立力, 孙玉林, 于馨, 等. 胸腺嘧啶依赖型金黄色葡萄球菌小菌落突变株的分离鉴定[J]. 中国畜牧兽医, 2014, 41(10):241-245.
[18] Ramiro R S, Costa H, Gordo I. Macrophage adaptation leads to parallel evolution of genetically diverse Escherichia coli small-colony variants with increased fitness in vivo and antibiotic collateral sensitivity[J]. Evolutionary Applications, 2016, 9(8):994-1004.
[19] 王奇惠, 朱立力, 时永强,等. 金黄色葡萄球菌小菌落突变株体外感染乳腺上皮细胞的研究[J]. 中国畜牧兽医, 2015, 42(8):2169-2175.
[20] 张元强. CCL20/CCR6趋化因子在IL-17介导的大鼠退变椎间盘自身免疫反应机制研究[D]. 济南:山东大学, 2016.
[21] Tuchscherr L, Medina E, Hussain M, et al. Staphylococcus aureus phenotype switching:An effective bacterial strategy to escape host immune response and establish a chronic infection[J]. EMBO Mol Med, 2011, 3(3):129-141.
[22] Gläser R, Becker K, von Eiff C, et al. Decreased susceptibility of Staphylococcus aureus small-colony variants toward human antimicrobial peptides[J]. Journal of Investigative Dermatology, 2014, 134(9):2347-2350.
[23] 冯晨晨. 低氧诱导因子-1与系统性红斑狼疮相关性的分子流行病学研究[D]. 合肥:安徽医科大学, 2014.
[24] 甄晓洲,黄笑妍,何智映, 等. JAK2/STAT3通路对低氧诱导的THP-1细胞炎症因子表达的影响[J]. 中国热带医学, 2017, 17(2):118-121.
[25] Werth N, Beerlage C, Rosenberger C, et al. Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens[J]. PLoS One, 2010, 5(7):e11576.
[26] 赵秋云, 袁富威, 刘瑞琪, 等. 细菌耐药性产生的分子机制及对细菌毒力的影响研究进展[J]. 动物医学进展, 2017, 38(2):71-74.
[27] Massey R C, Buckling A, Peacock S J. Phenotypic switching of antibiotic resistance circumvents permanent costs in Staphylococcus aureus[J]. Curr Biol, 2001, 11(22):1810-1814.
[28] Crompton M J, Dunstan R H, Macdonald M M, et al. Small changes in environmental parameters lead to alterations in antibiotic resistance, cell morphology and membrane fatty acid composition in Staphylococcus lugdunensis[J]. PLoS One, 2014, 9(4):e92296.
[29] Lim W S, Phang K K, Tan A H, et al. Small colony variants and single nucleotide variations in Pf1 region of PB1 phage-resistant Pseudomonas aeruginosa[J]. Front Microbiol, 2016, 7:282.
[30] Schmitz F J, von Eiff C, Gondolf M, et al. Staphylococcus aureus small colony variants:Rate of selection and MIC values compared to wild-type strains, using ciprofloxacin, ofloxacin, levofloxacin, sparfloxacin and moxifloxacin[J]. Clin Microbiol Infect, 1999, 5(6):376-378.
[31] Garcia L G, Lemaire S, Kahl B C, et al. Pharmacodynamic evaluation of the activity of antibiotics against hemin-and menadione-dependent small-colony variants of Staphylococcus aureus in models of extracellular (broth) and intracellular (THP-1 monocytes) infections[J]. Antimicrob Agents and Chemother, 2012, 56(7):3700-3711.
[32] Kim N H, Kang T M, Han W D, et al. Small colony variants in persistent and recurrent Staphylococcus aureus bacteremia[J]. Microb Drug Resist, 2016, 22(7):538-544.
[33] Alkasir R. 奶牛乳房炎金黄色葡萄球菌与化脓隐秘杆菌的生存策略:耐药性、生物膜以及小菌落突变株[D]. 北京:中国农业大学, 2015.

Research Progress on Adaptive Survival Relationship Between Small Colony Variants and Bacteria

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