苯唑西林敏感耐甲氧西林金黄色葡萄球菌研究进展

doi:10.16431/j.cnki.1671-7236.2017.08.034

Abstract

Abstract:

Staphylococcus aureus (S.aureus) is a gram-positive bacteria which could cause many kinds of infections, such as arthritis, endocarditis cellulitis, septicemia, pyemia and other systemic infections. In recent years, due to the unreasonable use of antibiotics, resistant Staphylococcus aureus increased rapidly.Particularly, the oxacillin-susceptible methicillin-resistant Staphylococcus aureus (OS-MRSA),it is a great challenge for clinical treatment. Understand the epidemiological characteristics and the mechanism of drug resistance of OS-MRSA can help clinicians to choose therapeutic drugs much better. This review summarized the research progress of epidemiology and resistant mechanism of OS-MRSA.

Key words: oxacillin-susceptible methicillin-resistant Staphylococcus aureus(OS-MRSA); epidemiology; resistant mechanism

CLC Number:

R446.5

ZHAO Wu-jing, XU Jin-qiang, WU Zhong-yong, PU Wan-xia. Research Progress on Oxacillin-susceptible Methicillin-resistant Staphylococcus aureus[J]. , 2017, 44(8): 2458-2464.

References

[1] 耐甲氧西林金黄色葡萄球菌感染防治专家委员会. 耐甲氧西林金黄色葡萄球菌感染防治专家共识2011年更新版[J].中华实验和临床感染病杂志(电子版), 2011, 5(3):66-72.
[2] 苏春康, 苏振文, 吴泉明. 金黄色葡萄球菌耐药性研究进展[A].两岸三地临床微生物与感染病学术论坛[C]. 2007.
[3] 黄山,尹久红,石瑾,等. MRSA对万古霉素敏感性4年监测分析[J]. 中国误诊学杂志, 2006, 6(15):2920-2921.
[4] 董泽欣, 夏永祥. 葡萄球菌耐药性的进展[J]. 检验医学与临床, 2012,22:2874-2876.
[5] 衷旺. 青霉素的发明[J]. 老同志之友, 2011,23:50.
[6] Kirby W M. Extraction of a highly potent penicillin inactivator from penicillin resistant staphylococci[J]. Science,1944, 99(2579):452-453.
[7] 李冬, 陈佰义. 耐甲氧西林金黄色葡萄球菌感染的治疗原则[J]. 中华结核和呼吸杂志, 2008, 31(4):318-320.
[8] Deresinski S.Methicillin-resistant Staphylococcus aureus:An evolutionary, epidemiologic, and therapeutic odyssey[J]. Clinical Infectious Diseases,2005,40(4):562-573.
[9] 张静. 全球MRSA负荷增加和潜在的临床提示[J]. 中华医学信息导报, 2008,13:11.
[10] Boucher H W,Corey G R.Epidemiology of methicillin-resistant Staphylococcus aureus[J]. Clin Infect Dis,2008,46(Suppl 5):S344-S349.
[11] 邢浩莉, 田恒忠. MRSA的耐性、抗性基因检测及院内感染防控措施[J]. 药物与人, 2014,12:26-27.
[12] Pournaras S, Stathopoulos C, Tsakris A. Oxacillin-susceptible MRSA:Couldit become a successful MRSA type[J]. Future Microbiology,2013,8(11):1365-1367.
[13] Aleixandregórriz I, Domínguezmárquez M V, Martínezmacías O, et al. Prevalence of Staphylococcus aureus carriers of mecA gene susceptible to cefoxitine:OS-MRSA[J]. Rev Esp Quimioter, 2014, 27(3):215-216.
[14] Cockerill F R. Performance Standards For Antimicrobial Susceptibility Testing:Twenty-third Informational Supplement[S]. Clinical and Laboratory Standards Institute,2013.
[15] Kampf G, Adena S, Rüden H, et al. Inducibility and potential role of MecA-gene-positive oxacillin-susceptible Staphylococcus aureus from colonized healthcare workers as a source for nosocomial infections[J]. Journal of Hospital Infection, 2003, 54(2):124-129.
[16] Petinaki E, Kontos F, Maniatis A N. Emergence of two oxacillin-susceptible mecA-positive Staphylococcus aureus clones in a Greek hospital[J]. Journal of Antimicrobial Chemotherapy,2002, 50(6):1090-1091.
[17] Chen F J, Hiramatsu K I. Panton-Valentine leukocidin (PVL)-positive methicillin-susceptible and resistant Staphylococcus aureus in Taiwan:Identification of oxacillin-susceptible mecA-positive methicillin-resistant S.aureus[J]. Diagnostic Microbiology & Infectious Disease,2009, 65(4):351-357.
[18] Hososaka Y, Hanaki H, Endo H, et al. Characterization of oxacillin-susceptible mecA-positive Staphylococcus aureus:A new type of MRSA[J]. Journal of Infection and Chemotherapy,2007, 13(2):79-86.
[19] Kumar V A, Steffy K, Chatterjee M, et al. Detection of oxacillin-susceptible mecA-positive Staphylococcus aureus isolates by use of chromogenic medium MRSA ID[J]. Journal of Clinical Microbiology,2013, 51(1):318-319.
[20] Forbes B A, Bombicino K, Plata K, et al. Unusual form of oxacillin resistance in methicillin-resistant Staphylococcus aureus clinical strains[J]. Diagnostic Microbiology & Infectious Disease,2008, 61(4):387-395.
[21] Chen F J, Huang I W, Wang C H, et al. mecA-positive Staphylococcus aureus with low-level oxacillin MIC in Taiwan[J]. Journal of Clinical Microbiology, 2012, 50(5):1679-1683.
[22] Conceição T, Coelho C, De L H, et al. Frequent occurrence of oxacillin-susceptible mecA-positive Staphylococcus aureus (OS-MRSA) strains in two African countries[J]. Journal of Antimicrobial Chemotherapy,2015, 70(12):3200-3204.
[23] Pu W, Su Y, Li J, et al. High incidence of oxacillin-susceptible meca-positive Staphylococcus aureus (OS-MRSA) associated with bovine mastitis in China[J]. PLoS One, 2014, 9(2):e88134.
[24] Saeed K, Ahmad N, Dryden M, et al. Oxacillin-susceptible methicillin-resistant Staphylococcus aureus(OS-MRSA), a hidden resistant mechanism among clinically significant isolates in the Wessex region/UK[J]. Infection, 2014, 42(5):843-847.
[25] Hiral M, Paresh S, Sudipta M, et al. Prevalence and characterization of oxacillin susceptible meca-positive clinical isolates of Staphylococcus aureus causing bovine mastitis in India[J].PLoS One, 2016, 11(9):e0162256.
[26] 贺文强,陈宏斌,赵春江,等. 我国苯唑西林敏感mecA阳性的金黄色葡萄球菌回顾性研究[J]. 中华检验医学杂志, 2014, 37(1):27-31.
[27] Andrade-Figueiredo M, Leal-Balbino T C. Clonal diversity and epidemiological characteristics of Staphylococcus aureus:High prevalence of oxacillin-susceptible mecA-positive Staphylococcus aureus, (OS-MRSA) associated with clinical isolates in Brazil[J].Bmc Microbiology,2016, 16(1):1-9.
[28] Sharff K A, Monecke S, Slaughter S, et al. Genotypic resistance testing creates new treatment challenges:Two cases of oxacillin-susceptible methicillin-resistant Staphylococcus aureus[J]. Journal of Clinical Microbiology,2012, 50(12):4151-4153.
[29] 辛德志. 近几年临床常见病原菌的分布特点及其耐药性分析[J]. 世界最新医学信息文摘,2015,7:134-135.
[30] Chambers H F. The changing epidemiology of Staphylococcus aureus?[J]. Emerging Infectious Diseases, 2001, 7(2):178.
[31] 肖永红, 王进, 赵彩云,等. 2006-2007年Mohnarin细菌耐药监测[J]. 中华医院感染学杂志, 2008, 18(8):1051-1056.
[32] Hu J C, Kornacker M G, Hochschild A. Escherichia colione-and two-hybrid systems for the analysis and identification of protein-protein interactions[J]. Methods, 2000, 20(1):80-94.
[33] Ladant D, Karimova G. Genetic systems for analyzing protein-protein interactions in bacteria[J]. Research in Microbiology, 2000, 151(9):711-720.
[34] Pinho M G, de Lencastre H, Tomasz A. An acquired and a native penicillin-binding protein cooperate in building the cell wall of drug-resistant staphylococci[J].Proc Natl Acad Sci USA,2001, 98(19):10886-10891.
[35] Katayama Y, Zhang H Z, Chambers H F. Effect of disruption of Staphylococcus aureus PBP4 gene on resistance to beta-lactam antibiotics[J].Microb Drug Resist, 2003, 9(4):329-336.
[36] De Lencastre H, dejonge B L,Matthews P R,et al.Molecular aspects of methicillin resistance in Staphylococcus aureus[J].J Antimicrob Chemother,1994,33(1):7-24.
[37] Enright M C, Robinson D A, Randle G,et al. The evolutionary history of methicillin-resistant Staphylococcus aureus(MRSA)[J]. Proc Natl Acad Sci USA,2002,99(11):7687-7692.
[38] Chambers H F.Methicillin resistance in staphylococci:Molecular and biochemical implications[J].Clin Microbiol,1997,10(4):781-791.
[39] 陈庆增, 罗兵, 孙迎娟,等. mecA基因在金黄色葡萄球菌中的分布及对耐药性的影响[J]. 中华医院感染学杂志, 2009, 19(9):1028-1031.
[40] Boyce J M.Methicillin-resistant Staphylococcus aureus. Detection, epidemiology, and control measures[J].Infectious Disease Clinics of North America, 1989, 3(4):901-913.
[41] Kobayashi N, Taniguchi K, Kojima K, et al. Genomic diversity of mec regulator genes in methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis[J]. Epidemiology & Infection, 1996, 117(2):289-295.
[42] 杜娜. 对苯唑西林耐药的金黄色葡萄球菌耐药性及分子流行病学调查[D]. 长春:吉林大学, 2007.
[43] Aoki W, Norris J E, Ryan S G, et al. Role of inhibition of penicillin binding proteins and cell wall cross-linking by beta-lactam antibiotics in low-and high-level methicillin resistance of Staphylococcus aureus[J]. Chemotherapy, 1999, 45(1):37-47.
[44] Falk K I, Ernberg I. Demethylation of the Epstein-barr virus origin of lytic replication and of the immediate early gene BZLF1 is DNA replication independent. Brief report[J]. Archives of Virology, 1999, 144(11):2219-2227.
[45] Kraus R J, Mirocha S J, Stephany H M, et al.Identification of a novel element involved in regulation of the lytic switch BZLF1 gene promoter of Epstein-Barr virus[J]. Journal of Virology, 2001, 75(2):867-877.
[46] 林艳玲. 利奈唑胺、万古霉素体外诱导耐甲氧西林金黄色葡萄球菌耐药株转录组学及适应性的研究[D]. 汕头:汕头大学, 2015.
[47] 李展城, 蔡大可, 舒友平,等. 丹参水溶性物质SA-B对TGF-β1活化细胞内Smad与p38MAPK信号传导通路的抑制作用[J]. 中国民族民间医药, 2016, 25(9):18-19.
[48] 贺明, 董晓景, 李忠磊,等. SIPI8294增效β-内酰胺类抗生素抗MRSA作用机制研究[A].中华医学会第十二次全国临床微生物学术年会暨第十一次全球华人临床微生物学与感染症学术年会论文汇编[C]. 2015.
[49] 彭苑霞. 大黄素对金黄色葡萄球菌抑制作用的蛋白质组学研研究[D].广州:广州中医药大学, 2014.
[50] 吴本权, 唐英春. MRSA PBP2a表达的影响因素及MecA基因的检测价值[J]. 中山大学学报医学科学版, 2000, 21(2):157-159.
[51] Giannouli S, Labrou M, Kyritsis A, et al. Detection of mutations in the FemXAB protein family in oxacillin-susceptible mecA-positive Staphylococcus aureus clinical isolates[J]. Journal of Antimicrobial Chemotherapy,2010,65(4):626-633
[52] Meng J, Hu B, Liu J, et al. Restoration of oxacillin susceptibility in methicillin-resistant Staphylococcus aureus by blocking the MecR1-mediated signaling pathway[J]. Journal of Chemotherapy, 2006, 18(4):360-365.
[53] Kumar V A, Steffy K, Chatterjee M, et al. Detection of oxacillin-susceptible meca-positive Staphylococcus aureusisolates by use of chromogenic medium MRSA ID[J]. Journal of Clinical Microbiology, 2013, 51(1):318-319.
[54] Murakami K, Minamide W, Wada K, et al. Identification of methicillin-resistant strains of staphylococci by polymerase chain reaction[J]. Journal of Clinical Microbiology, 1991, 29(10):2240-2244.
[55] Chung M, Kim C K, Conceição T, et al. Heterogeneousoxacillin-resistant phenotypes and production of PBP2A by oxacillin-susceptible/mecA-positive MRSA strains from Africa[J]. Journal of Antimicrobial Chemotherapy,2016, 71(10):2804-2809.
[56] 苏洋, 蒲万霞, 陈智华,等. 牛源金黄色葡萄球菌的耐药性及耐甲氧西林金黄色葡萄球菌的检测[J]. 中国农业科学, 2012, 45(17):3602-3607.
[57] 苏洋. 奶牛乳房炎耐甲氧西林金黄色葡萄球菌的检测及基因分型[D]. 兰州:甘肃农业大学, 2013.
[58] 陈振鸿. 质粒编码的超广谱β-内酰胺酶CTX-M-55及碳青霉烯酶NDM-1和IMP-1的分子遗传特征研究[D]. 北京:中国人民解放军医学院,2014.

Research Progress on Oxacillin-susceptible Methicillin-resistant Staphylococcus aureus

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	KANG Pu, REN Zhaowen, CAI Rujian, LYU Zongji, HUANG Yuhao, WANG Xiaohu. Variation Regularity and Transmission of PRRSV-2 Lineage 8 Strains in Guangdong and Surrounding Provinces [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 2001-2011.
[2]	LIANG Yingxin, CHEN Zejia, LI Jichao, CUI Xiaoxiao, FENG Qianqi, LI Shoujun, CHEN Aolei. Investigation on the Infection of Equine Intestinal Parasite in Partial Cities in Guangdong Province [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(7): 2725-2734.
[3]	GUO Luanying, LI Jialei, JIN Qinqin, MA Jun, LIU Quan. Research Progress on Bovine Hepacivirus [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(5): 1994-2000.
[4]	YIN Yanwen, SHI Kaichuang, SUN Wenchao, XIE Shouyu, QU Sujie, LU Wenjun, WANG Luxia, QIN Yong, PEI Xingbiao, LING Dan. Surveillance Analysis of Low Pathogenic Avian Influenza Virus in Border Areas of Guangxi from 2013 to 2019 [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(8): 3002-3009.
[5]	ZHANG Shuang, GUO Yu, XUE Wenhui, ZHAO Qianhui, HUO Shuying. Research Progress on Poultry Candida glabrata [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(3): 1013-1019.
[6]	SUN Jiali, DONG Hao, PENG Xiaowei, ZHU Liangquan, JIANG Hui, FENG Yu, LI Xiaoying, DING Jiabo, WANG Chunfeng. Research Progress on Brucella canis [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(10): 3803-3811.
[7]	WANG Jiayun, WANG Xin, WANG Bingyu, ZENG Hao, SHEN Wenhui, YU Jiang, CHEN Zhi, ZHANG Yuyu, SUN Wenbo, GUO Lihui, REN Sufang, LI Yubao, WU Jiaqiang. Epidemiological Investigation of CSFV in Shandong Province from 2017 to 2019 [J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(6): 1870-1881.
[8]	CHEN Qian, WANG Kunlun, YAN Yaqun, ZHOU Yongchun, ZHAO Cong, JIAN Fuchun, WANG Rongjun, ZHANG Longxian, NING Changshen. Molecular Epidemiological Investigation and Genetic Evolution Analysis of Theileria luwenshuni in Sheep and Goats in Different Regions of China [J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(6): 1902-1909.
[9]	LIU Hanyang, ZHANG Yi, XIAO Ran, CHEN Bin, WU Yongsheng, SU Zhipeng, LI Yupeng, PEI Chaoxin, XU Zhenying, ZHU Jiawen. Molecular Epidemiological Investigation on ORF5 Gene of Porcine Reproductive and Respiratory Syndrome Virus in Sichuan in 2018 [J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(4): 1172-1182.
[10]	DUAN Qunpeng, ZHAO Shuo, QIN Yibin, LU Bingxia, HE Ying, CHEN Zhongwei, LIU Lei, ZHOU Yingning, LI Bin, JIANG Dongfu, LIANG Jiaxing, ZHAO Wu. Epidemiological Investigation Analysis of Porcine Circovirus Type 3 in Guangxi [J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(4): 1183-1190.
[11]	YANG Chunjie, LIU Xueting, MI Xue, CHEN Ying, WEI Zuzhang, HUANG Weijian, OUYANG Kang. Epidemiological Investigation and VP1 Gene Sequence Analysis of Porcine Enterovirus Type G in Guangxi [J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(4): 1216-1224.
[12]	DUAN Qunpeng, LI Xiaoyu, ZHAO Shuo, QIN Yibin, LU Bingxia, LI Bin, SU Qianlian, ZHAO Wu, HE Ying, LIANG Jiaxing, JIANG Dongfu, ZHOU Yingning, CHEN Zhongwei. A Epidemiological Investigation on Diarrhea Viral Disease of Piglets in Some Pig Farms in Guangxi During 2016 to 2019 [J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(2): 564-574.
[13]	LI Shaohan, ZHANG Guangzhi, CUI Shangjin, QIN Tong. Research Progress of Canine Coronavirus and Feline Coronavirus [J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(12): 4059-4068.
[14]	JIANG Xinhua, ZHOU Hetian, LUO Feng, YANG Danfeng, ZHANG Zhiqing, CHEN Songchang, DENG Shunzhou. Molecular Epidemiological Investigation of Porcine Epidemic Diarrhea Virus in Jiangxi Province in 2017 [J]. , 2019, 46(5): 1474-1482.
[15]	GUO Yingcheng, FU Shoupeng, GAO Xueyong, LI Xudong. Molecular Epidemiological Investigation and Genetic Evolution Analysis of Porcine Circovirus Type 3 in Jilin Province [J]. , 2019, 46(5): 1483-1490.