Abstract:

The study was aimed to explore the hypoglycemic effect of theGynura formosana Kitam., which would provide a scientific basis for clinical expansion. This research adopted the water extraction of Gynura formosana Kitam. dry paste. Some experimental animals were divided into different dose groups, and intragastrically administrated for 5 days, and used metformin as the positive control drug in the body load cases by tail vein blood glucose and glucose tolerance area under the curve as testing indexes, so that we could study the effect of Gynura formosana Kitam. on the normal glucose tolerance for mice. Test in 30 to 120 min later, when the mice were drench in the fifth crude drug dosage (1 g/d), the blood glucose dropped rapidly, and at the moment of the 120th min, (tendency for 3.16 mmol/L) the blood glucose level was less than the 0 benchmark of blood glucose (4.00 mmol/L). 1 to 2 g/d glucose tolerance area under curve of crude drug dosage was less than the metformin group of glucose tolerance area under the curve. We could work out that 1 to 2 g/d for Gynura formosana Kitam. oral liquid, insisted on taking them for 5 days, would restrained (suppress) gastrointestinal sugar in the body to absorb glucose load situations, and its effect is better than that of metformin hydrochloride.

Key words: Gynura formosana Kitam.; blood glucose levels; SBG