›› 2017, Vol. 44 ›› Issue (5): 1462-1467.doi: 10.16431/j.cnki.1671-7236.2017.05.029

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Research Progress on Role of IL-10 in Immunodulation during Mycobacterium tuberculosis Infection

ZHU Ting-ting1,2, PU Peng1,2, LIU Han1,2, PENG Yong-chong1,2, CHEN Ying-yu1,2, GUO Ai-zhen1,2   

  1. 1. State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China;
    2. College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China
  • Received:2016-10-31 Online:2017-05-20 Published:2017-05-18

Abstract:

Interleukin 10 (IL-10) is a versatile and multi-cell derived cytokine, which has attracted the great attention of researchers because of its strong anti-inflammation and immunosuppression activities. It can not only inhibit the innate but also adaptive immunity. Generally, it is believed that IL-10 is closely related to immune evasion and latent infection by Mycobacterium tuberculosis (MTB). In view of its unique role in MTB infection, progress of role of IL-10 on immune evasion, latent infection, clinical chemotherapies and self-regulation of its expression during MTB infection were reviewed.

Key words: IL-10; Mycobacterium tuberculosis; immunomodulation; infection

CLC Number: