H9N2亚型禽流感病毒与其他病原混合感染的研究进展

doi:10.16431/j.cnki.1671-7236.2021.09.037

Abstract

Abstract: H9N2 subtype Avian influenza virus (AIV) is a low pathogenic AIV. However, it is widely prevalent and spreads quickly, and can decline the performance of infected poultry, bringing great economic losses to the poultry industry. H9N2 subtype AIV can cause severe immunosuppression in the infected poultry, making it easier to be co-infection with upper respiratory tract bacteria and digestive tract bacteria. The co-infection with bacteria results in increasing of pathogenicity of H9N2 subtype AIV, and enhanced ability of bacterial adhesion and colonization, leading to a significant elevation in poultry mortality. Besides, H9N2 subtype AIV can co-infect with avian Infectious bronchitis virus, avian Infectious bursal disease virus, and Newcastle disease virus, etc., and there may be synergistic or antagonistic effects when the virus invades, thereby mutually promoting or inhibiting viral replication and shedding. Moreover, H9N2 subtype AIV is prone to mutation or genetic recombination with other subtypes of Influenza viruses to produce new influenza strains that may infect humans, posing a great threat to public health worldwide. This paper summarized the research advance of mixed infection of H9N2 subtype AIV and other pathogens. By expounding the synergistic or antagonistic effects between H9N2 subtype AIV and bacteria or other viruses, it is hoped to provide a reference for the prevention and treatment of H9N2 subtype AIV associated co-infection in the clinic.

Key words: H9N2 subtype Avian influenza virus; bacteria; virus; co-infection

CLC Number:

S855

JIANG Ning, YIN Hang, ZHANG Yanwei, LI Zixin, CHI Xiaojuan, WANG Song. Research Progress on Co-infection of H9N2 Subtype Avian Influenza Virus with Other Pathogens[J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(9): 3447-3455.

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Research Progress on Co-infection of H9N2 Subtype Avian Influenza Virus with Other Pathogens

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