合生素和抗菌肽对肉仔鸡大肠杆菌病的防制效果及免疫调节作用

doi:10.16431/j.cnki.1671-7236.2017.03.037

Abstract

Abstract:

This experiment was to study the effect of synbiotic and antibacterial peptide on growth performance,and the immune regulation of broiler chickens after the E.coli O78 attack. Totally 100 broilers of health 1-day-old Ross 308 were randomly divided into four treatment groups:Synbiotic group (group S) was fed with basal diet+0.3% synbiotic;Antibacterial peptides group (group AP) was fed with basal diet+0.5% antibacterial peptide; Antibacterial peptide+synbiotic group (group SAP) was fed with basal diet+0.3% synbiotic+0.5% antibacterial peptide;Control group (group C) was fed with basal diet,and the growth performance were determined. At the 14th day,10 chickens from each group were randomly selected for muscle injection with E.coli O78 (the attacked control group was named as model group (group M)),and after 24 h,the morbidity,mortality and immune function of chickens in each group were determined. The results showed that compared with control group,the F/G and ADF of groups S and AP were significantly decreased (P<0.05).Before E.coli O78 attack,the bursa index of group SAP was significantly higher than control group (P<0.05),and other groups had no significant difference (P>0.05);While after the E.coli O78 attack,the thymus,spleen and bursa indexes of groups S and AP were significantly higher than control group (P<0.05),the spleen and bursa indexes of group SAP were significantly higher than control group (P<0.05),and the thymus index showed no significant difference (P>0.05).Compared with the group M,the IgA,sIgA and IL-10 of group S showed no significant difference (P>0.05),while the IL-6 levels decreased extremely significantly (P<0.01);The IgA and IL-6 of group AP were extremely significantly decreased (P<0.01),meanwhile the sIgA and IL-10 were significantly or extremely significantly higher (P<0.05;P<0.01); The changed trend of SAP group was the same as the group AP.In conclusion,the synbiotic and antibacterial peptide could improve the feed conversion rate of chickens and they were used alone or combination all could improved chicken immune function after the bacteria attack.

Key words: synbiotics; antibacterial peptide; broiler chickens; colibacillosis; immune

CLC Number:

S816.73

ZHU Qi, GUO Ming, HE Lan, YANG Chun-lei, LI Yu-peng, LI Hai-hua, QIAO Jia-yun, WANG Jian-guo, WANG Wen-jie. Effect of Synbiotic and Antibacterial Peptide on Colibacillosis and Immune Regulation in Broiler Chickens[J]. , 2017, 44(3): 888-895.

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Effect of Synbiotic and Antibacterial Peptide on Colibacillosis and Immune Regulation in Broiler Chickens

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