畜禽MHCⅠ分子抗原结合槽研究进展

doi:10.16431/j.cnki.1671-7236.2016.08.021

Abstract

Abstract:

The determination of major histocompatibility complex (MHC) classⅠcomplex structure can elucidate the antigen-binding mechanism,and then effectively utilize the specific CTL response.Currently,several MHCⅠstructures of the livestock and poultry are reported,containing cattle MHCⅠ allele (N*01301,N*01801),pig (SLA-1*0401) and chicken (BF2*2101,BF2*0401,BF2*0201 and BF2*1401).All above MHCⅠstructures are composed of α1,α2,α3 and β₂m chains;And the antigen groove is consisted of six pockets (A,B,C,D,E and F).Generally speaking,how different MHCⅠ binds miscellaneous peptides depends on the B and F pockets.In addition,the MHCⅠsequences have intraspecific and interspecific differences,so the peptides are various for different MHCⅠmolecules.But,different MHCⅠmolecules also can present same peptide,implementing the peptides of cross-presentation.The determination of animal MHCⅠstructures will promote the immunology and vaccine application research.

Key words: livestock; poultry; MHC Ⅰ; antigen binding groove

CLC Number:

R392.11

HAO Fu-xing, JU Yuan-zhao, JIN Hong-yan, FENG Jia-wang, YUAN Wei-feng. Research Progress on Livestock and Poultry MHCⅠAntigen Binding Groove[J]. , 2016, 43(8): 2072-2080.

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Research Progress on Livestock and Poultry MHCⅠAntigen Binding Groove

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