长链非编码RNA在肌肉发育中的作用研究进展

›› 2014, Vol. 41 ›› Issue (11): 232-236.

长链非编码RNA在肌肉发育中的作用研究进展

李艳艳^1,2, 顾志良¹

1. 常熟理工学院生物与食品工程学院, 江苏常熟 215500;
2. 苏州大学基础医学与生物科学学院, 江苏苏州 215000

收稿日期:2014-03-27 出版日期:2014-11-20 发布日期:2014-12-06
通讯作者: 顾志良 E-mail:zhilianggu88@hotmail.com
作者简介:李艳艳(1988-),女,河南人,硕士生,研究方向:动物分子遗传学。
基金资助:
国家自然科学基金(30871789、31272438)。

Research Progress of Long Noncoding RNA in Muscle Development

LI Yan-yan^1,2, GU Zhi-liang¹

1. College of Biological Science and Food Engineering, Changshu Institute of Technology, Changshu 215500, China;
2. College of Preclinical Medicine and Biological Science, Soochow University, Suzhou 215000, China

Received:2014-03-27 Online:2014-11-20 Published:2014-12-06

摘要/Abstract

摘要： 长链非编码RNA(long noncoding RNA, lncRNA)是一类长度大于200个核苷酸且不具有蛋白编码功能的RNA转录本,研究表明它参与了基因组印记、转录激活与干扰、转录后调控、染色体剂量补偿效应、发育调控等众多生物过程。作者就lncRNA的发现和分类、生物学功能及与肌肉发育相关lncRNA等研究进展进行了综述。

关键词: 长链非编码RNA; 生物学功能; 肌肉发育

Abstract: Long noncoding RNA (lncRNA) is a class of RNA being more than 200 nucleotides in length, which also has no protein coding function. The researches suggest that lncRNA can mediate genomic imprinting, transcriptional activation and interference, post transcriptional regulation, chromosome dosage compensation effect, developmental regulation and many other biological processes. The detection and classification, biological function of lncRNAs, and the research progress of lncRNAs associated with muscle development would be reviewed in this paper.

Key words: long noncoding RNA; biological functions; muscle development

中图分类号:

Q522

李艳艳, 顾志良. 长链非编码RNA在肌肉发育中的作用研究进展[J]. , 2014, 41(11): 232-236.

LI Yan-yan, GU Zhi-liang. Research Progress of Long Noncoding RNA in Muscle Development[J]. China Animal Husbandry & Veterinary Medicine, 2014, 41(11): 232-236.

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