抗球虫药氯氟苄腺嘌呤的研究进展

›› 2013, Vol. 40 ›› Issue (4): 225-228.

抗球虫药氯氟苄腺嘌呤的研究进展

谢金富¹, 李美娣², 武力²

1. 广州市高级技工学校,广东广州 510410;
2. 广州华农大实验兽药有限公司,广东广州 510642

收稿日期:2012-11-12 出版日期:2013-04-20 发布日期:2013-04-19
通讯作者: 武力(1970-),男,福建人,高级兽医师,研究方向:新兽药研发、推广和企业管理。
作者简介:谢金富(1969-),男,浙江人,讲师,研究方向:临床兽医学。

Research Progress on the Coccidiostat of Arprinocide

XIE Jin-fu¹, LI Mei-di², WU Li²

1. Guangzhou Technician College,Guangzhou 510410, China;
2. Guangzhou Huanongda Experimental Veterinary Drug Co.,Ltd.,Guangzhou 510642,China

Received:2012-11-12 Online:2013-04-20 Published:2013-04-19

摘要/Abstract

摘要： 氯氟苄腺嘌呤属于核苷酸类化合物,是一种新型抗球虫药,具有广谱的抗球虫活性,目前在中国尚未有相关的产品上市。作者主要阐述了氯氟苄腺嘌呤的作用机理、国内外研究进展,并分析了其在鸡球虫病防制方面的应用前景,为氯氟苄腺嘌呤在中国的研究、推广和应用提供参考依据。

关键词: 氯氟苄腺嘌呤; 球虫病; 研究进展

Abstract: Arprinocide was one of a class of ribonucleotide possessing broad-spectrum anticoccidial activity in chickens, and there were no relative products in China. The author reviewed the mechanism of action and the current study of arprinocid at home and abroad, and analysed the application prospect of prevention and treatment coccidiosis in chickens,which could provide the reference evidence to study, spread and use for chickens in the farms.

Key words: arprinocide; coccidiosis; research progress

中图分类号:

Q526

谢金富, 李美娣, 武力. 抗球虫药氯氟苄腺嘌呤的研究进展[J]. , 2013, 40(4): 225-228.

XIE Jin-fu, LI Mei-di, WU Li. Research Progress on the Coccidiostat of Arprinocide[J]. , 2013, 40(4): 225-228.

参考文献

1 冯连礼,刚松堂,蒋国胜,等.鸡坏死性肠炎与鸡球虫病混合感染的诊治[J].河南畜牧兽医,2003,24(11):27.
2 张守权,于庆和,沈维力.鸡球虫病并发坏死性肠炎的诊治[J].中国兽医寄生虫病,2007,15(1):59~60.
3 张红英,开爱民.鸡球虫病与鸡霍乱混合感染的诊治[J].湖北畜牧兽医,2007(7):25.
4 程学慧,彭健,詹志春,等.抗生素在畜牧生产中面临的挑战和出路[J].中国畜牧兽医,2004,31(2):13~15.
5 Anadon A,Martinez-larranaga M R. Residus of antimicrobial drugs and feed additives in animal products: Regulatory aspects[J].Livestock Production Science,1999,59(2):183~198.
6 Brewer R N,Kowalski L M. Coccidiosis: Evaluation of anticoccidial in floor-pen trials[J].Exp Parasitol,1970,28(1):64~71.
7 Chapman H D. Eimeria tenella: Development of resistance to arprinocid and decoquinate in the chicken[J]. Res Vet Sci,1985,38(2):226~230.
8 Dilov P,Chaleva E,Dzhurov A,et al. Species-specific toxicity of arprinocid in mammals and birds[J]. Vet Med Nauki,1983,20(9):59~67.
9 Fink D W,Fox A,Pivnichny J V. High pressure liquid chromatographic determination of arprinocid in feed[J]. J Assoc Off Anal Chem,1979,62(1):1~4.
10 Fink D W. Liquid chromatographic method for determination of arprinocid in feed: Collaborative study[J]. J Assoc Off Anal Chem,1981,64(4):973~979.
11 Jacob T A,Alvaro R F,Chapin L R,et al. Tissue residues of arprinocid in chickens. 1. Depletion of residues in tissues of chickens fed carbon-14-labeled arprinocid[J]. J Agric Food Chem,1982,30(2):248~253.
12 Keshavarz K,McDougald L R. Anticoccidial drugs: Growth and performance depressing effects in young chickens[J]. Poultry Sci,1982(61):699~705.
13 Kilgore R L,Bramel R G,Brokken E S,et al. Efficacy of arprinocid (MK-302) against Eimeria species in broilers[J]. Poult Sci,1978,57(4):907~911.
14 Latter V S,Wilson R G. Factors influencing the assessment of anticoccidial activity in cell culture[J]. Parasitology,1979,79(1):169~175.
15 Mark L D. Industry must keep in touch with growing consumer power[J]. Poultry World,2004,158(1):7~8.
16 McManus E C. The effect of arprinocid on the reproductive potential of a field isolate of Eimeria tenella[J]. J Parasitol,1980a,66(6):926~928.
17 McManus E C,Olson G,Pulliam J D. Effects of arprinocid on developmental stages of Eimeria tenella[J]. J Parasitol,1980b,66(5):765~770.
18 McQuistion T E,McDougald L R. Anticoccidial activity of arprinocid and halofuginone[J]. Vet Parasitol,1981,9(1):27~33.
19 Olson G,Tamas T,Smith D A,et al. Battery efficacy studies with arprinocid against field strains of coccidia[J]. Poult Sci,1978,57(5):1245~1250.
20 Rehg J E,Hancock M L. Effectiveness of arprinocid in the reduction of cryptosporidial activity in immunosuppressed rats[J]. Am J Vet Res,1990,51(10):1668~1670.
21 Rieux A,Gras S,Lecaille F,et al. Eimeripain,a cathepsin B-like cysteine protease,expressed throughout sporulation of the apicomplexan parasite Eimeria tenella[J].PLoS One,2012,7(3):e31914.
22 Ruff M D,Reid W M,Dykstra D D,et al. Efficacy of arprinocid against coccidiosis of broilers in battery and floor-pen trials[J]. Avian Dis,1978,22(1):32~41.
23 Schroder J,Smith C J Z,Harvey R G. The anticoccidial efficacy of arprinocid in broiler chickens under floor pen conditions[J]. Journal of the South African Veterinary Association,1980,51(1):59~61.
24 Shirley M W,Harvey D A. Eimeria tenella: Genetic recombination of markers for precocious development and arprinocid resistance[J]. Appl Parasitol,1996,37(4):293~299.
25 Tway P C,Wood Jr J S,Downing G V,et al. Determination of arprinocid in chicken tissues by gas chromatography-mass spectrometry[J]. J Agric Food Chem,1979,27(4):753~756.
26 Wang C C,Tolman R L,Simashkevich P M,et al. Arprinocid,an inhibitor of hypoxanthine-guanine transport[J]. Biochemical Pharmacology,1979,28(15):2249~2260.
27 Wang C C,Simashkevich P M,Fan S S. The mechanism of anticoccidial action of arprinocid-1-N-oxide[J]. J Parasitol,1981,67(2):137~149.

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