牛乳头瘤病毒的研究进展

doi:10.16431/j.cnki.1671-7236.2015.06.044

摘要/Abstract

摘要： 牛乳头状瘤(bovine papillomatosis,BP)是由牛乳头瘤病毒(bovine papillomavirus,BPV)引起的一种传染性肿瘤病.该病易复发进而癌变,给养殖业等造成严重经济损失.作者主要对BPV的基因型、基因结构及其功能和致病机制方面的研究进展作一综述,为深入研究BPV致癌潜能及抗病毒疫苗的开发提供参考.

关键词: 乳头瘤病毒; 牛; 研究进展

Abstract: Bovine papilloma (BP) is a infectious papilloma induced by bovine papillomavirus (BPV).This disease is easily to recur and evolve into cancer,leading to severe loss of breeding industry.The author mainly summarize the gene types,genetic structure,function of genes and pathogenic mechanism of BPV,providing important references to further study the carcinogenic potential of BPV and to develop antiviral vaccines.

Key words: papillomavirus; bovine; research progress

中图分类号:

S852.65

史巧芸, 庞峰, 杜丽, 王凤阳. 牛乳头瘤病毒的研究进展[J]. 《中国畜牧兽医》---唯一指定的官方网站, 2015, 42(6): 1613-1619.

SHI Qiao-yun, PANG Feng, DU Li, WANG Feng-yang. Research Progress on Bovine Papillomavirus[J]. , 2015, 42(6): 1613-1619.

参考文献

[1] zur Hausen H.Papillomavirus infections——A major cause of human cancers[J].Biochim Biophys Acta,1996,1288(2):55-78.

[2] Carr J,Gyorfi T.Human papillomavirus,epidemiology,transmission,and pathogenesis[J].Clin Lab Med,2000,20(2):235-255.

[3] Brandt S,Apprich V,Hackl V,et al.Prevalence of bovine papillomavirus and treponema DNA in bovine digital dermatitis lesions[J].Vet Microbiol,2011,148(2-4):161-167.

[4] Lima E G,Lira R C,Jesus A L,et al.Development of a DNA-based vaccine strategy against bovine papillomavirus infection,involving the E5 or L2 gene[J].Genet Mol Res,2014,13(1):1121-1126.

[5] Carvalho C C,Batista M V,Silva M A,et al.Detection of bovine papillomavirus types,co-infection and a putative new BPV11 subtype in cattle[J].Transbound Emerg Dis,2012,59(5):441-447.

[6] Borzacchiello G,Roperto F.Bovine papillomaviruses,papillomas and cancer in cattle[J].Vet Res,2008,39(5):45.

[7] Creech G T.Experimental studies of the etiology of common warts in cattle[J].Agr Res,1929,29:723-737.

[8] Resendes A R,Roperto S,Trapani F,et al.Association of bovine papillomavirus type 2 (BPV-2) and urinary bladder tumours in cattle from the Azores archipelago[J].Res Vet Sci,2011,90(3):526-529.

[9] Roperto S,Russo V,Ozkul A,et al.Bovine papillomavirus type 2 infects the urinary bladder of water buffalo (Bubalus bubalis) and plays a crucial rolein bubaline urothelial carcinogenesis[J].J Gen Virol,2013,94(Pt2):403-408.

[10] Jarrett W F,Campo M S,O'Neil B W,et al.A novel bovine papillomavirus (BPV-6) causing true epithelial papillomas of the mammary gland skin:A member of a proposed new BPV subgroup[J].Virology,1984,136(2):255-264.

[11] Hatama S,Ishihara R,Ueda Y,et al.Detection of a novel bovine papillomavirus type 11 (BPV-11) using xipapillomavirus consensus polymerase chain reaction primers[J].Arch Virol,2011,156(7):1281-1285.

[12] Zhu W,Dong J,Shimizu E,et al.Characterization of novel bovine papillomavirus type 12 (BPV-12) causing epithelial papilloma[J].Arch Virol,2012,157(1):85-91.

[13] Bloch N,Sutton R H,Spradbrow P B.Bovine cutaneous papillomas associated with bovine papillomavirus type 5[J].Arch Virol,1994,138(3-4):373-377.

[14] Tomita Y,Literak I,Ogawa T,et al.Complete genomes and phylogenetic positions of bovine papillomavirus type 8 and a variant type from a European bison[J].Virus Genes,2007,35(2):243-249.

[15] da Costa R M G,Bastos M M,Oliveira P A,et al.Bracken-associated human and animal health hazards:Chemical,biological and pathological evidence[J].J Hazard Mater,2012,203:1-12.

[16] Campo M S.Papillomavirus and disease in humans and animals[J].Vet Comp Oncol,2003,1(1):3-14.

[17] Danos O,Giri I,Thierry F,et al.Papillomavirus genomes:Sequences and consequences[J].Journal of Investigative Dermatology,1984,83:7-11.

[18] Freitas A C,Silva M A R,Jesus A L S,et al.Recent insights into bovine papillomavirus[J].Afr J Microbiol Res,2010,5(33):6004-6012.

[19] Bergvall M,Melendy T,Archambault J.The E1 proteins[J].Virology,2013,445(1-2):35-56.

[20] Li B,Yu C,Yin J,et al.Enhanced transgene expression in mammalian cells by recombinant baculovirus vector containing bovine papillomavirus type 1 replication elements[J].J Gene Med,2013,15(8-9):282-290.

[21] 贺志昊.新疆北疆地区牛乳头瘤病毒流行株基因分型及其衣壳蛋白表达研究[D].石河子:石河子大学,2014.

[22] Doorbar J.The E4 protein,structure,function and patterns of expression[J].Virology,2013,445(1-2):80-98.

[23] Anderson R A,Scobie L,O'Neil B W,et al.Viral proteins of bovine papillomavirus type 4 during the development of alimentary canal tumours[J].Vet J,1997,154:69-78.

[24] Venuti A,Paolini F,Nasir L,et al.Papillomavirus E5:The smallest oncoprotein with many functions[J].Mol Cancer,2011,10:140.

[25] Surti T,Klein O,Aschheim K,et al.Structural models of the bovine papillomavirus E5 protein[J].Proteins,1998,33:601-612.

[26] DiMaio D,Petti L M.The E5 proteins[J].Virology,2013,445(1-2):99-114.

[27] Conrad M,Bubb V J,Schlegel R.The human papillomavirus type 6 and 16 E5 proteinsare membrane-associated proteins which associate with the 16-kilodalton pore-forming protein[J].J Virol,1993,67(10):6170-6178.

[28] Goldstein D J,Finbow M E,Andresson T,et al.Bovine papillomavirus E5 oncoprotein binds to the 16K component of vacuolar H⁽⁺⁾-ATPases[J].Nature,1991,352(6333):347-349.

[29] Corteggio A,Altamura G,Roperto F,et al.Bovine papillomavirus E5 and E7 oncoproteins in naturally occurring tumors:Are two better than one[J].Infect Agent Cancer,2013,8(1):1.

[30] Ashrafi G H,Tsirimonaki E,Marchetti B,et al.Down-regulation of MHC class Ⅰ by bovine papillomavirus E5 oncoproteins[J].Oncogene,2002,21(2):248-259.

[31] Ashrafi G H,Brown D R,Fife K H,et al.Down-regulation of MHC class Ⅰ is a property common to papillomavirus E5 proteins[J].Virus Res,2006,120(1-2):208-211.

[32] Schlegel R,Wade-Glass M,Rabson M S,et al.The E5 transforming gene of bovine papillo-mavirus encodes a small,hydrophobic polypeptide[J].Science,1986,233(4762):464-467.

[33] Bohl J,Hull B,Vande Pol S B.Cooperative transformation and coexpression of bovine papillomavirus type 1 E5 and E7 proteins[J].J Virol,2001,75(1):513-521.

[34] Borzacchiello G,Russo V,Spoleto C,et al.Bovine papillomavirus type-2 DNA and expression of E5 and E7 oncoproteins in vascular tumours of the urinarybladder in cattle[J].Cancer Lett,2007,250(1):82-91.

[35] DeMasi J,Chao M C,Kumar A S,et al.Bovine papillomavirus E7 oncoprotein inhibits anoikis[J].J Virol,2007,81(17):9419-9425.

[36] Sarver N,Rabson M S,Yang Y C,et al.Localization and analysis of bovine papillomavirus type 1 transforming functions[J].J Virol,1984,52(2):377-388.

[37] Buck C B,Trus B L.The papillomavirus virion:A machine built to hide molecular Achilles' heels[J].Adv Exp Med Biol,2012,726:403-422.

[38] Love A J,Chapman S N,Matic S,et al.In planta production of a candidate vaccine against bovine papillomavirus type 1[J].Planta,2012,236(4):1305-1313.

[39] Doorbar J.The papillomavirus life cycle[J].J Clin Virol,2005,32(1):7-15.

[40] Modis Y,Trus B L,Harrison S C.Atomic model of the papillomavirus capsid[J].EMBO J,2002,21(18):4754-4762.

[41] Duensing S,Münger K.The human papillomavirus type 16 E6 and E7 oncoproteins independently induce numerical and structuralchromosome instability[J].Cancer Res,2002,62(23):7075-7082.

[42] Campo M S.Papillomavirus research:From natural history to vaccines and beyond[M].UK:Caister Academic Press,2006.

[43] Collins A,Anderson D,Coskun E,et al.Launch of the ComNet (comet network) project on the comet assay in human population studies during the international comet assay workshop meeting in Kusadasi,Turkey (September 13-16,2011)[J].Mutagenesis,2012,27(4):385-386.

[44] Liu Y,Baleja J D.Structure and function of the papillomavirus E6 protein and its interacting proteins[J].Front Biosci,2008,13:121-134.

[45] Wade R,Brimer N,Vande P S.Transformation by bovine papillomavirus type 1 E6 requires paxillin[J].J Virol,2008,82(12):5962-5966.

[46] Melo T C,Diniz N,Campos S R,et al.Cytogenetic studies in peripheral blood of bovines afflicted by papillomatosis[J].Vet Comp Oncol,2011,9(4):269-274.

[47] Latorre A O,Caniceiro B D,Fukumasu H,et al.Ptaquiloside reduces NK cell activities by enhancing metallothionein expression,which is prevented by selenium[J].Toxicology,2013,304:100-108.

[48] 武晓英,张春香,任有蛇,等.硒与动物疾病防治[J].中国畜牧兽医,2009,12(36):125-127.

[49] Latorre A O,Caniceiro B D,Wysocki H L,et al.Selenium reverses pteridium aquilinum-induced immunotoxic effects[J].Food Chem Toxicol,2011,49(2):464-470.

[50] Suzuki S,Takada T,Sugawara Y,et al.Quercetin induces recombinational mutations in cultured cells as detected by DNA fingerprinting[J].Jpn J Cancer Res,1991,82(10):1061-1064.

[51] Beniston R G,Morgan I M,O'Brien V,et al.Quercetin,E7 and p53 in papillomavirus oncogenic cell transformation[J].Carcinogenesis,2001,22(7):1069-1076.

[52] Pennie W D,Campo M S.Synergism between bovine papillomavirus type 4 and the flavonoid quercetin in cell transformation in vitro[J].Virology,1992,190(2):861-865.

[53] Connolly J A,Morgan I M,Jackson M E,et al.The BPV-4 co-carcinogen quercetin induces cell cycle arrest and up-regulates transcription from the LCR of BPV-4[J].Oncogene,1998,16(21):2739-2746.

[54] Lucena R B,Rissi D R,Kommers G D,et al.A retrospective study of 586 tumours in Brazilian cattle[J].J Comp Pathol,2011,145(1):20-24.

[55] Melo T C,Diniz N,Campos S R,et al.Cytogenetic studies in peripheral blood of bovines afflicted by papillomatosis[J].Vet Comp Oncol,2011,9(4):269-274.

[56] Wobeser B K,Hill J E,Jackson M L,et al.Localization of bovine papillomavirus in equine sarcoids and inflammatory skin conditions of horses using laser microdissection and two forms of DNA amplification[J].J Vet Diagn Invest,2012,24(1):32-41.

[57] Buck C B,Day P M,Trus B L.The papillomavirus major capsid protein L1[J].Virology,2013,445(1-2):169-174.

[58] Borzacchiello G,Iovane G,Marcante M L,et al.Presence of bovine papillomavirus type 2 DNA and expression of the viral oncoprotein E5 in naturally occurring urinary bladder tumours in cows[J].J Gen Virol,2003,84(11):2921-2926.

[59] Campo M S.Animal models of papillomavirus pathogenesis[J].Virus Res,2002,89(2):249-261.