营养与表观遗传修饰关系的研究进展

doi:10.16431/j.cnki.1671-7236.2015.07.020

摘要/Abstract

摘要： 表观遗传学是在DNA碱基序列不变的前提下引起的基因表达或细胞表观型变化的一种遗传现象。经典遗传学理论认为DNA序列的遗传能够主导亲代基因传递给后代,但越来越多的证据表明营养等环境因素对基因表达具有重要的修饰作用,如营养因素可通过DNA甲基化、组蛋白修饰和microRNA(miRNA)调控等作用来影响表观遗传,且营养素对机体健康的保持有着非常重要的作用(尤其是生命早期的营养)。作者就动物或人长期暴露在蛋白质缺乏、能量不足、高脂和采食过度等营养不平衡日粮条件下,以及一些特殊的营养素作用条件下,其表观遗传修饰的变化及作用机制方面的最新研究进展进行综述,旨在为后续的深入研究提供参考。

关键词: 营养; 表观遗传学; 机制; 研究进展

Abstract: Epigenetics is a branch of genetics to study the gene expression of heritable changes when nucleotide sequence has no change.Although classical genetics theory deems that genetic DNA sequence can dominate parental gene to their offspring,growing evidence suggests that environmental factors such as nutrition play an important role in modifying genetic expression.Nutrition can affect epigenetics by DNA methylation,histone modification and microRNA (miRNA).More and more researches prove that nutrition (especially early-life nutrition) is very important to keep the body healthy.The author mainly focused on the research progress about the relationship between nutrition and epigenetic modification and its mechanism,including animal or human chronically expose on the feed condition of protein and energy deficiency,high fat,overfeeding and some especial nutrients to provide reference for the further study.

Key words: nutrition; epigenetics; mechanism; research progress

中图分类号:

Q3-05

宋善丹, 陈光吉, 饶开晴, 徐亚欧. 营养与表观遗传修饰关系的研究进展[J]. , 2015, 42(7): 1755-1762.

SONG Shan-dan, CHEN Guang-ji, RAO Kai-qing, XU Ya-ou. Research Progress on Relationship between Nutrition and Epigenetic Modification[J]. , 2015, 42(7): 1755-1762.

参考文献

[1] Horton R.Maternal and child undernutrition:An urgent opportunity[J].Lancet,2008,371(9608):179-180.
[2] Victora C G,Adair L,Fall C,et al.Maternal and child undernutrition:Consequences for adult health and human capital[J].Lancet,2008,371(9609):340-357.
[3] Saenger P,Czernichow P,Hughes I,et al.Small for gestational age:Short stature and beyond[J].Endocrine Reviews,2007,28(2):219-251.
[4] Russell S J,Kahn C R.Endocrine regulation of ageing[J].Nature Reviews Molecular Cell Biology,2007,8(9):681-691.
[5] Pentinat T,Ramon-Krauel M,Cebria J,et al.Transgenerational inheritance of glucose intolerance in a mouse model of neonatal overnutrition[J].Endocrinology,2010,151(12):5617-5623.
[6] Barker D J,Bull A R,Osmond C,et al.Fetal and placental size and risk of hypertension in adult life[J].British Medical Journal,1990,301(6746):259-262.
[7] Jaenisch R,Bird A.Epigenetic regulation of gene expression:How the genome integrates intrinsic and environmental signals[J].Nature Genetics,2003,33(Suppl):245-254.
[8] Dams C D,Uthus E O.DNA methylation,cancer susceptibility,and nutrient interactions[J].Experimental Biology and Medicine,2004,229(10):988-995.
[9] Bernstein B E,Meissner A,Lander E S.The mammalian epigenome[J].Cell,2007,128(4):669-681.
[10] Fuchs J,Demidov D,Houben A,et al.Chromosomal histone modification patterns-from conservation to diversity[J].Trends in Plant Science,2000,11(4):199-208.
[11] Huntzinger E,Lzaurralde E.Gene silencing by microRNAs:Contributions of translational repression and mRNA decay[J].Nature Reviews Genetics,2011,12(2):99-110.
[12] 胡士军,杨增明.miRNAs的表达调控机制[J].生物化学与生物物理进展,2008,35(5):483-487.
[13] Santos F,Hendrich B,Reik W,et al.Dynamic reprogramming of DNA methylation in the early mouse embryo[J].Developmental Biology,2002,241(1):172-182.
[14] Morgan H D,Santos F,Green K,et al.Epigenetic reprogramming in mammals[J].Human Molecular Genetics,2005,14(1):R47-R58.
[15] Lees-Murdock D J,Walsh C P.DNA methylation reprogramming in the germ line[J].Epigenetics,2008,626:5-13.
[16] Rees W D,Hay S M,Brown D S,et al.Maternal protein deficiency causes hypermethylation of DNA in the livers of rat fetuses[J].The Journal of Nutrition,2000,130(7):1821-1826.
[17] Lillycrop K A,Phillips E S,Jackson A A,et al.Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring[J].The Journal of Nutrition 2005,135(6):1382-1386.
[18] Lillycrop K A,Phillips E S,Torrens C,et al.Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring[J].British Journal of Nutrition,2008,100(2):278-282.
[19] Lillycrop K A,Slater-Jefferies J L,Hanson M A,et al.Burdge,induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications[J].British Journal of Nutrition,2007,97(6):1064-1073.
[20] Sandovici I,Smith N H,Nitert M D,et al.Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4α gene in rat pancreatic islets[J].Proceeding of the National Academy Science USA,2011,108(13):5449-5454.
[21] Coupe B,Amarger V,Grit I,et al.Nutritional programming affects hypothalamic organization and early response to leptin[J].Endocrinology,2010,151(2):702-713.
[22] Kaminsky Z A,Tang T,Wang S C,et al.DNA methylation profiles in monozygotic and dizygotic twins[J].Nature Genetics,2009,41(2):240-245.
[23] Lueder F L,Ogata E S.Uterine artery ligation in the maternal rat alters fetal issue glucose utilization[J].Pediatric Research,2009,28(5):464-468.
[24] Park J H,Stoffers D A,Nicholls R D,et al.Development of type 2 diabetes following intrauterine growthretardation in rats is associated with progressive epigenetic silencing of Pdx1[J].Journal of Clinical Investigation,2008,118(6):2316-2324.
[25] Fu Q,McKnight R A,Yu X,et al.Growth retardation alters the epigenetic characteristics of hepatic dual specificity phosphatase 5[J].FASEB Journal,2006,20(12):2127-2129.
[26] Sohi G,Marchand K,Revesz A,et al.Maternal protein restriction elevates cholesterol in adult rat offspring due to repressive changes in histone modifications at the cholesterol 7alpha-hydroxylase promoter[J].Molecular Endocrinology,2011,25(5):785-798.
[27] Ke X,McKnight R A,Caprau D,et al.Intrauterine growth restriction affects hippocampal dual specificity phosphatase 5 gene expression and epigenetic characteristic[J].Physiological Genomics,2011,43(20):1160-1169.
[28] Ke X,Schober M E,McKnight R A,et al.Intrauterine growth retardation affects expression and epigenetic characteristics of the rat hippocampal glucocorticoid receptor gene[J].Physiological Genomics,2010,42(2):177-189.
[29] Baserga M,Kaur R,Hale M A,et al.Fetal growth restriction alters transcription factor binding and epigenetic mechanisms of renal 11 beta-hydroxysteroid dehydrogenase type 2 in a sex-specific manner[J].Gastrointestinal and Liver Physiology American Journal of Physiology,2010,299(1):R334-R342.
[30] Joss-Moore L A,Albertine K H,Lane R H.Epigenetics and the developmental origins of lung disease[J].Molecular Genetics and Genomics,2011,104(1-2):61-66.
[31] Vucetic Z,Kimmel J,Totoki K,et al.Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes[J].Endocrinology,2010,151(10):4756-4764.
[32] Bruce K D,Cagampang F R,Argenton M,et al.Maternal high-fat feeding primes steatohepatitis in adult mice offspring,involving mitochondrial dysfunction and altered lipogenesis gene expression[J].Hepatolog,2009,50(6):1796-1808.
[33] Aagaard-Tillery K M,Grove K,Bishop J,et al.Developmental origins of disease and determinants of chromatin structure:Maternal diet modifies the primate fetal epigenome[J].Molecular Endocrinology,2008,41(2):91-102.
[34] Plagemann A,Roepke K,Harder T,et al.Epigenetic malprogramming of the insulin receptor promoter due to developmental overfeeding[J].Journal of Perinatal Medicine,2010,38(4):393-400.
[35] Plagemann A,Harder T,Brunn M,et al.Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding:An epigenetic model of obesity and the metabolic syndrome[J].Journal of Physiology,2009,587(20):4963-4976.
[36] 赖玉娇,罗海玲,王朕朕,等.甜菜碱的生理学功能及其在畜牧生产中应用的研究进展[J].中国畜牧兽医,2014,41(1):101-107.
[37] 王斯佳.胆碱生物学效价评定及其在肉鸡体内代谢与需要量的研究[D].北京:中国农业科学院,2012.
[38] 范文莉.VitA、VitB2辅助硫酸亚铁叶酸片治疗孕妇贫血的疗效及对妊娠结局的影响[J].中国妇幼保健,2014,20:3250-3252.
[39] 倪娟,陈海燕,曹能,等.不同氧化态叶酸对人成淋巴细胞系基因DNA甲基化水平的影响[J].肿瘤防治研究,2014,41(3):256-259.
[40] Sie K K Y,Medline A,Van Weel J,et al.Effect of maternal and postweaning folic acid supplementation on colorectal cancer risk in the offspring[J].Gut,2011,60(12):1687-1694.
[41] Niculescu M D,Craciunescu C N,Zeisel S H.Dietary choline deficiency alters global and gene specific DNA methylation in the developing hippocampus of mouse fetal brains[J].The FASEB Journal,2006,20(1):43-49.
[42] Link A,Balaguer F,Shen Y,et al.Curcumin modulates DNA methylation in colorectal cancer cells[J].PLoS One,2013,8(2):e57709.
[43] 陈其慧,李瑜元,周永健,等.姜黄素对非酒精性脂肪性肝病大鼠PGC1α基因去甲基化的作用[J].广州医学院学报,2013,41(4):13-17.
[44] 李新刚,陈燕,吴青,等.姜黄素调节NB4细胞P53和组蛋白H3乙酰化抑制细胞增殖的研究[J].中华血液学杂志,2006,26(9):551-553.
[45] 汪丽佩,赵燕娜,高瑞兰.白藜芦醇抑制K562细胞增殖过程中WT1基因表达及其甲基化水平的变化[J].中华血液学杂志,2014,35(3):245-246.
[46] Ko H,So Y,Jeon H,et al.TGF-β1-inducedepithelial-mesenchymal transition and acetylation of Smad2 and Smad3 are negatively regulated by EGCG in human A549 lung cancer cells[J].Cancer Lett,2013,335(1):205-213.
[47] Thakur V S,Gupta K,Gupta S.Green tea polyphenols increase p53 transcriptional activity and acetylation by suppressing class Ⅰ histone deacetylases[J].Int J Oncol,2012,41(1):353-361.
[48] Tahiliani M,Koh K P,Shen Y,et al.Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1[J].Science,2009,324:930-935.
[49] Ito S,Shen L,Dai Q,et al.Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine[J].Science,2011,333:1300-1303.
[50] He Y F,Li B Z,Li Z,et al.Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA[J].Science,2011,333(6047):1303-1307.
[51] Hackett J A,Sengupta R,Zylicz J J,et al.Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine[J].Science,2013,339:448-452.
[52] Yin R,Mao S Q,Zhao B,et al.Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals[J].J Am Chem Soc,2013,135:10396-10403.
[53] Blaschke K,Ebata K,Karimi M,et al.Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells[J].Nature,2013,500:222-226.
[54] Wu H,Wu Y,Ai Z,et al.Vitamin C enhances nanog expression via activation of the JAK/STAT signaling pathway[J].Stem Cells,2014,32:166-176.
[55] Gao Y,Yang L,Chen L,et al.Vitamin C facilitates pluripotent stem cell maintenance by promoting pluripotency gene transcription[J].Biochimie,2013,95:2107-2113.
[56] Feil R,Fraga M F.Epigenetics and the environment:Emerging patterns and implications[J].Nature Reviews Genetics,2012,13:97-109.
[57] Teperino R,Schoonjans K,Auwerx J.Histone methyl transferases and demethylases;Can they link metabolism and transcription[J].Cell Metabolism,2010,12(4):321-327.
[58] Anand R,Marmorstein R.Structure and mechanism of lysine-specific demethylase enzymes[J].The Journal of Biological Chemistry,2007,282(49):35425-35429.
[59] Sealy L,Chalkley R.The effect of sodium butyrate on histone modification[J].Cell,1987,14(1):115-121.
[60] Davie J R.Inhibition of histone deacetylase activity by butyrate[J].The Journal of Nutrition,2003,133(7):2485S-2493S.
[61] Guarente L,Picar F.Calorie restriction——The SIR2 connection[J].Cell,2005,120(4):473-482.
[62] Esquela-kerscher A,Slack F J.Oncomirs——microRNAs with a role in cancer[J].Nature Reviews Cancer,2006,6(4):259-269.
[63] Bao B,Rodriguez-Melendez R,Wijeratne S S,et al.Biotin regulates the expression of holocarboxylase synthetase in the miR-539 pathway in HEK-293 cells[J].The Journal of Nutrition,2010,140(9):1546-1551.
[64] Noratto G D,Angel-Morales G,Talcott S T,et al.Polyphenolics from acai (Euterpe oleracea Mart.) and red muscadine grape (Vitis rotundifolia) protect human umbilical vascular endothelial cells (HUVEC) from glucose- and lipopolysaccharide (LPS)-induced inflammation and target microRNA-126[J].Journal of Agricultural and Food Chemistry,2011,59(14):7999-8012.
[65] Zhang J,Zhang F,Didelot X,et al.Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring[J].BMC Genomics,2009,10:478.
[66] Parra P,Serra F,Palou A.Expression of adipose microRNAs is sensitive to dietary conjugated linoleic acid treatment in mice[J].PLoS One,2010,5(9):e13005.
[67] Gaedicke S,Zhang X,Schmelzer C,et al.Vitamin E dependent microRNA regulation in rat liver[J].FEBS Letts,2008,582(23-24):3542-3546.