关键词: 双酚A (BPA); 畜禽; 毒代动力学; 生殖毒性; 清除策略

Abstract: Bisphenol A (BPA),as an endocrine disruptor with estrogenic activity,is widely used in daily products such as food packaging,medical equipment,and children’s toys due to its high heat resistance and durability.BPA accumulates in soil,water and other environments,and enters the human body through diet,skin contact,and other pathways.BPA binds to estrogen receptors,interferes with hormone balance in the body,and poses a potential threat to human health.Among them,BPA has the most significant damage to the reproductive system.To this end,human have developed various BPA alternatives such as BPS and BPF,but these BPA alternatives have also been detected globally,and their environmental and health impacts cannot be ignored.In recent years,BPA and its substitutes have been widely found in animal manure and excrement,breeding environments,as well as animal products such as meat,eggs,and milk in intensive scale livestock and poultry farming.The manure and urine produced by intensive livestock and poultry farming are important sources of BPA and its substitutes in the environment,which pose a threat to human health through diet and contact pathways.Human have developed various detection methods and clearance strategies for BPA and its alternatives,while research on intensive livestock and poultry farming is relatively scarce.The authors summarize the population distribution,toxicokinetics,environmental risk assessment,impact on the reproductive system,detection methods,and clearance strategies of BPA and its substitutes in livestock and poultry breeding environments,aiming to provide theoretical basis for the prevention and control of bisphenol compound pollution in large-scale livestock and poultry breeding.

Key words: bisphenol A (BPA); livestock and poultry; toxicokinetics; reproductive toxicity; remediation strategies