组蛋白去乙酰化酶参与畜禽病毒感染的作用及机制

doi:10.16431/j.cnki.1671-7236.2024.03.038

摘要/Abstract

摘要： 畜禽在养殖过程中易受病毒感染,给养殖业造成严重的经济损失,其中部分畜禽病毒(如乙脑病毒和口蹄疫病毒)属于人兽共患性病原,对养殖工作人员及消费者健康也可造成潜在威胁。因此,防控畜禽病毒不仅可减少养殖业经济损失,同时对保障公共健康也十分重要。组蛋白去乙酰化酶(histone deacetylase,HDACs)属于表观遗传修饰酶,可通过调控组蛋白乙酰化过程影响基因表达,继而参与多种生命活动过程。大量研究表明,HDACs可通过与病毒蛋白互作或影响细胞相关信号通路来参与多种畜禽病毒感染过程,且HDACs抑制剂处理可抑制部分病毒(如伪狂犬病病毒和马立克病毒)复制,提示HDACs可作为抗畜禽病毒感染的广谱抗病毒药物靶点。因此,深入了解HDACs参与畜禽病毒感染的过程对防控畜禽病毒感染具有重要意义。作者简要介绍了HDACs及其抑制剂,重点综述了HDACs参与畜禽病毒感染的作用及机制,为深入研究HDACs调控畜禽病毒感染提供参考,为开发新型抗病毒药物提供科学指导。

关键词: 组蛋白去乙酰化酶(HDACs); 抑制剂; 畜禽病毒感染; 作用及机制

Abstract: Livestock and poultry are easy to suffer from virus infection during the breeding process,which causes serious economic losses to the breeding industries.In addition,some viruses belong to zoonotic pathogens (including Japanese encephalitis virus and Foot-and-mouth disease virus),which pose potential threats to the public health of livestock workers and consumers.Therefore,the prevention and control of livestock and poultry viruses not only can reduce economic losses in the breeding industry,but also is very important for safeguarding public health.Histone deacetylases (HDACs) belong to the epigenetic modification enzymes,which affect gene expression by regulating the histone acetylation process, so as to participate in various life activity processes.Numerous studies have shown that HDACs participate in various animal virus infection processes by interacting with viral proteins or influencing cellular signaling pathways,and HDAC inhibitor treatment can inhibit the replication of some viruses (such as Pseudorabies virus and Marek’s disease virus),suggesting that HDACs can serve as broad-spectrum antiviral drug targets against animal virus infection.Deeper investigation of the involvement of HDACs in livestock and poultry virus infection is of great significance for the prevention and control of livestock and poultry virus infection.The author briefly introduces HDACs and their inhibitors,mainly summarizes the roles and mechanisms of HDACs in animal virus infection.This review will provide reference for in-depth research on the regulation of HDACs in livestock and poultry virus infection,and provide guidance for developing novel antiviral agents against virus infection.

Key words: histone deacetylases (HDACs); inhibitors; livestock and poultry virus infection; role and mechanism

中图分类号:

S852.65

谭磊, 彭小烨, 王开心, 黄小久, 张帆, 禹思宇. 组蛋白去乙酰化酶参与畜禽病毒感染的作用及机制[J]. 中国畜牧兽医, 2024, 51(3): 1259-1266.

TAN Lei, PENG Xiaoye, WANG Kaixin, HUANG Xiaojiu, ZHANG Fan, YU Siyu. Role and Mechanism of Histone Deacetylase in Livestock and Poultry Virus Infection[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(3): 1259-1266.

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