›› 2010, Vol. 37 ›› Issue (6): 25-29.

• 生理生化 • 上一篇    下一篇

营养介导的TOR信号传导研究进展

刘宁1,2, 刘国华1, 蔡辉益1, 邓雪娟1, 王苑1, 张姝1, 常文环1, 郑爱娟1   

  1. (1.中国农业科学院饲料研究所, 北京 100081; 2.河南科技大学动物科技学院, 洛阳 471003)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-06-20 发布日期:2010-06-20
  • 通讯作者: 蔡辉益

Advances in Nutrient Regulation of TOR Signal Transduction

LIU Ning1,2, LIU Guo-hua1, CAI Hui-yi1, DENG Xue-juan1,
WANG Yuan1, ZHANG Shu1, CHANG Wen-huan1, ZHENG Ai-juan1
  

  1. (1.Feed Institue,Chinese Academy of Agricultural Sciences,Beijing 100081,China; 2.School of Animal Science,Henan University of Science and Technology,Luoyang 471003,China)
  • Received:1900-01-01 Revised:1900-01-01 Online:2010-06-20 Published:2010-06-20
  • Contact: CAI Hui-yi

摘要: TOR(target of rapamycin)是一种结构和功能高度保守的蛋白激酶,它能够通过整合营养、能量、生长因子等信号调节细胞的增殖、体积增大及细胞周期进程。作者综述了TOR激酶的上下游信号传导途径及氨基酸和能量等营养状况对这些信号传导通路和细胞生长的影响,为探讨营养调控体蛋白合成的机制及精准营养供给技术的建立提供宝贵的理论基础和开创性思路。

关键词: 氨基酸; 能量; TOR; 信号传导; 细胞生长

Abstract: TOR(target of rapamycin),a protein kinase with high conservation in structure and function from yeast to mammalian, controls the cell growth and cycle progress by integrating the nutrient, energy and growth factors. The authors reviewed TOR kinase and the related upstream and downstream signaling pathways, and the regulation of amino acid and energy on these signals and subsequently cell growth, for establishing the mechanism of nutrient regulating protein position and providing a new insight into the technology of exact nutrient provision.

Key words: amino acids; energy; TOR; signal transduction; cell growth

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