›› 2009, Vol. 36 ›› Issue (8): 99-102.

• 遗传繁育 • 上一篇    下一篇

Fas/FasL系统调控公牛精子发生的研究进展

张清峰   

  1. (菏泽学院动物科学系, 菏泽 274015)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2009-08-20 发布日期:2009-08-20

Research Progress of Regulating Bovine Spermatogenesis by Fas/FasL System

ZHANG Qing-feng   

  1. (Animal Science Department, Heze University, Heze 274015, China)
  • Received:1900-01-01 Revised:1900-01-01 Online:2009-08-20 Published:2009-08-20

摘要: 牛的精子发生是一个特殊的雄性生殖细胞的分化、增殖和凋亡的过程。在这一过程中,生殖细胞总是不断地处于分化和凋亡的动态平衡之中。凋亡信号转导分子Fas和FasL组成的Fas/FasL系统不但在细胞自稳和疾病发生中具有重要作用,而且参与调控牛的精子发生。当Fas和FasL表达异常时,直接影响生殖细胞的发育和增殖。作者通过阐明Fas/FasL系统在牛精子发生过程中的调控机理,为提高种公牛的繁殖性能开创一条新的途径。

关键词: Fas(CD95/AP01); FasL; 细胞凋亡; 精子发生

Abstract: Cattle spermatogenesis is a special male germ cell differentiation, proliferation and apoptosis process. In this process, reproductive cells have always kept in the dynamic equilibrium of differentiation and apoptosis. Apoptotic signal transduction molecule Fas and FasL not only plays an important role in cells stability and disease, but also regulated the cattle spermatogenesis.It direct impact on the development and proliferation of germ cells when the abnormal expression of Fas and FasL. This paper elucidated the regulation mechanism of Fas/FasL system in cattle spermatogenesis, in order to improve the bull breeding performance to found a new channel.

Key words: Fas (CD95/AP01); FasL; apoptosis; spermatogenesis

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