白藜芦醇对畜禽常见肝损伤保护机制及应用的研究进展

doi:10.16431/j.cnki.1671-7236.2020.11.014

摘要/Abstract

摘要： 近年来随着畜禽养殖的集约化与规模化的不断发展，畜禽容易遭受来自饲料发霉、抗生素滥用及肝炎病毒等因素产生的肝损伤。白藜芦醇是一种广泛存在于多种植物中的天然植物提取物，属于多酚类物质，在食品科学和医学领域中可以改善肝脏疾病造成的肝损伤。同时，白藜芦醇可以有效保护畜禽肝脏，缓解炎症刺激、氧化应激以及细胞凋亡等生理或病理状态时产生的肝损伤。另外，白藜芦醇可以通过调节畜禽脂代谢，改善生长育肥阶段容易出现的非酒精性脂肪肝所导致的肝损伤。作者综合了白藜芦醇对畜禽肝损伤保护作用的研究进展，简述了白藜芦醇的理化性质和相关生物学功能，如抗炎、抗氧化、抗细胞凋亡，同时介绍了畜禽常见肝损伤的主要类型和病理途径，并分析了白藜芦醇对畜禽常见肝损伤保护机制和相关信号通路，以期为白藜芦醇通过改善畜禽常见肝损伤、提高畜产品品质提供依据，为探究白藜芦醇成为一种新型优质的饲料添加剂的可能性提供理论支撑。

关键词: 白藜芦醇; 肝脏保护; 抗炎; 抗氧化; 抗细胞凋亡; 肝损伤

Abstract: In recent years,with the intensive and large-scale development of livestock and poultry breeding,livestock and poultry are vulnerable to liver damage caused by feed mildew, antibiotic abuse,hepatitis virus and other factors.Resveratrol is a natural plant extract which is widely found in many plants.It belongs to polyphenols,which can improve liver damage caused by liver disease in the field of food science and medicine.At the same time, resveratrol can effectively protect the liver of livestock and poultry,relieve inflammation stimulation,oxidative stress,apoptosis and other physiological or pathological conditions of liver damage.In addition,resveratrol can improve the liver damage caused by non-alcoholic fatty liver that is prone to appear in the growth and fattening stage by regulating the lipid metabolism of livestock and poultry.The authors summarized the research progress of the protective effect of resveratrol on liver injury of livestock and poultry, briefly described it's physical and chemical properties and related biological functions, such as anti-inflammatory,anti-oxidation,anti-apoptosis.At the same time,the main types and pathologic ways of liver injury in livestock and poultry were introduced, and the protective mechanism and signal pathway of resveratrol to liver injury in livestock and poultry were analyzed,in order to provide the basis for resveratrol to improve the common liver injury of livestock and poultry and improve the quality of livestock products,and to provide theoretical support for exploring the possibility of resveratrol as a new high quality feed additive.

Key words: resveratrol; liver protection; anti-inflammation; anti-oxidation; anti-apoptosis; liver injury

中图分类号:

TQ463

杨浩, 金三俊, 庞倩, 冯兴军. 白藜芦醇对畜禽常见肝损伤保护机制及应用的研究进展[J]. 中国畜牧兽医, 2020, 47(11): 3528-3535.

YANG Hao, JIN Sanjun, PANG Qian, FENG Xingjun. Research Progress on the Protective Mechanism and Application of Resveratrol to Common Liver Injury in Livestock and Poultry[J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(11): 3528-3535.

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