天然产物对动物繁殖影响研究进展

doi:10.16431/j.cnki.1671-7236.2024.01.018

摘要/Abstract

摘要： 自然界中的天然产物是来源于植物、动物和微生物体内的构成成分或生物体内的代谢成分及各种内源性化学成分，主要包括植物天然产物、动物天然产物和微生物天然产物。天然产物对动物繁殖性状存在调控作用。对于雄性生殖来说，天然产物主要影响精子发生、精子活力及性行为活动，促进雄性动物生殖的天然产物有淫羊藿苷、枸杞多糖、蒺藜皂甙等，而大麻提取物、印楝素等对雄性生殖产生负面影响。对于雌性生殖来说，天然产物主要影响卵子发生、卵泡发育及胎儿生长发育，茶多酚、白藜芦醇、染料木黄酮、林蛙油等天然产物能促进雌性动物生殖，桔霉素、姜黄素等能抑制雌性动物生殖；天然产物中激素类对于雌性动物繁殖的影响最大，从卵子发生到胚胎发育的各个阶段均有参与；在妊娠期，母体吸收的天然产物对胎儿发育会产生一定的影响。作者主要综述了天然产物对动物繁殖的影响，为天然产物在动物繁殖调控中的应用提供参考。

关键词: 天然产物; 繁殖; 精子发生; 卵泡发育; 抗氧化

Abstract: Natural products are derived from the components of plants, animals and microorganisms, or the metabolic components and various endogenous chemical components in organisms, mainly including plant natural products, animal natural products and microbial natural products.Natural products have a regulatory effect on animal reproductive traits.For male reproduction, natural products mainly affect spermatogenesis, sperm motility and sexual activity, in which the natural products that promote male animal reproduction include icariin, lycium barbarum polysaccharide, tribulus terrestris saponins and so on, while cannabis extract, neem, and so on have a negative impact on male reproduction.Concerning female reproduction, natural products mainly affect oogenesis, follicular development and fetal growth and development.Tea polyphenols, resveratrol, genistein, forest frog oil and other natural products can increase female reproductive capacity, while citrinin, curcumin, and other natural products can decrease female prolificacy.Hormones in natural product have the greatest influence on the reproduction of female animals, which involved in various stages from oogenesis to embryo development.During pregnancy, natural products absorbed by the mother will have certain effects on fetal development.The author mainly reviews the effects of natural products on animal reproduction, in order to provide a reference for the application of natural products in the regulation of animal reproduction.

Key words: natural products; reproduction; spermatogenesis; follicle development; antioxidant

中图分类号:

S814

刘彬, 刘彦, 郑琛, 冯涛. 天然产物对动物繁殖影响研究进展[J]. 中国畜牧兽医, 2024, 51(1): 172-182.

LIU Bin, LIU Yan, ZHENG Chen, FENG Tao. Research Progress on the Effects of Natural Products on Animal Reproduction[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(1): 172-182.

参考文献

[1] LIANG J, ZHANG B, HU Y, et al.Effects of steroid hormones on lipid metabolism in sexual dimorphism:A Mendelian randomization study[J].Frontiers in Endocrinology, 2023, 13:1119154.
[2] 贺天雨, 王尉, 曹学丽.天然产物国家标准样品研制进展及回顾[J].中国标准化, 2022, 17:129-135. HE T Y, WANG W, CAO X L.Development and review of national reference materials of natural products[J].China Standardization, 2022, 17:129-135.(in Chinese)
[3] 李永娟, 周文豪.中草药研究进展及其在养殖中的应用[J].今日畜牧兽医, 2018, 34(6):56-58. LI Y J, ZHOU W H.Research progress of Chinese herbal medicine and its application in breeding[J].Today Animal Husbandry Veterinary Medicine, 2018, 34(6):56-58.(in Chinese)
[4] 吴冬梅, 廖飞.中草药在猪生产中的研究进展[J].安徽农业科学, 2021, 49(23):1-4. WU D M, LIAO F.Research progress of Chinese herbal medicine in pig production[J].Journal of Anhui Agricultural Sciences, 2021, 49(23):1-4.(in Chinese)
[5] 王宏, 刘月, 杨梁钰, 等.生物碱类化合物抗病毒活性及其机制研究进展[J].中草药, 2022, 53(9):2839-2850. WANG H, LIU Y, YANG L Y, et al.Research progress on antiviral activities and mechanism of alkaloids[J].Chinese Materia Medica, 2022, 53(9):2839-2850.(in Chinese)
[6] ZHEN Z W, TI Q Z, JING R Z, et al.Discovery of pentacyclic triterpenoid glycosides with anti-proliferative activities from Ardisia lindleyana[J].Carbohydrate Research, 2023, 524:108761.
[7] KIM S K, HIMAYA S W A.Triterpene glycosides from sea cucumbers and their biological activities[J].Advances in Food and Nutrition Research, 2012, 65:297-319.
[8] 兰晓光.小麦胚芽的营养价值及开发利用[J].农业工程技术, 2022, 42(14):89-90. LAN X G.Development and utilization of wheat germ[J].Agricultural Engineering Technology, 2022, 42(14):89-90.(in Chinese)
[9] OJO B A, O'HARA C, WU L, et al.Wheat germ supplementation increases Lactobacillaceae and promotes an anti-inflammatory gut milieu in C57BL/6 mice fed a high-fat, high-sucrose diet[J].The Journal of Nutrition, 2019, 149(7):1107-1115.
[10] 陈飞雪, 包志华.小麦胚芽营养价值及发酵食品的研究进展[J].农产品加工, 2016, 6:66-67. CHEN F X, BAO Z H.Research progress of nutritional value of wheat germ and fermented food[J].Farm Products Processing, 2016, 6:66-67.(in Chinese)
[11] 高月锋.n-3多不饱和脂肪酸对雌性动物繁殖性能的影响[J].现代畜牧兽医, 2022, 9:47-51. GAO Y F.Effect of n-3 polyunsaturated fatty acids on reproductive performance on female animals[J].Modern Journal of Animal Husbandry and Veterinary Medicine, 2022, 9:47-51.(in Chinese)
[12] POLANOWSKA K, ŁUKASIK R M, KULIGOWSKI M, et al.Development of a sustainable, simple, and robust method for efficient L-DOPA extraction[J]. Molecules, 2019, 24(12):2325.
[13] CARBONARO M, MASELLI P, NUCARA A.Structural aspects of legume proteins and nutraceutical properties[J].Food Research International, 2015, 76:19-30.
[14] ZHAO P W, JIAN J Y, REN M Y.Progress on effective components and mechanism of medicinal and edible traditional Chinese herbs in treating obesity[J].Journal of Guangdong Pharmaceutical University, 2021, 37(3):141-149.
[15] 欧阳立力, 华萍.药食同源花类植物活性成分与药理作用研究进展[J].江西化工, 2020, 36(6):58-60. OUYANG L L, HUA P.Research progress in active components and functions of the flower plants homology of medicine and food[J].Jiangxi Chemical Industry, 2020, 36(6):58-60.(in Chinese)
[16] 唐雪阳, 谢果珍, 周融融, 等.药食同源的发展与应用概况[J].中国现代中药, 2020, 22(9):1428-1433. TANG X Y, XIE G Z, ZHOU R R, et al.Development and application of ‘one root of medicine and food’[J].Modern Chinese Medicine, 2020, 22(9):1428-1433.(in Chinese)
[17] WINTER G, HART R A, CHARLESWORTH R P G, et al.Gut microbiome and depression:What we know and what we need to know[J].Nature Reviews Neuroscience, 2018, 29(6):629-643.
[18] ZAWAWI N, CHONG P J, MOHD TOM N N, et al.Establishing relationship between vitamins, total phenolic and total flavonoid content and antioxidant activities in various honey types[J].Molecules, 2021, 26(15):4399.
[19] ALLIOUCHE KERBOUA K, BENOSMANE L, NAMOUNE S, et al.Anti-inflammatory and antioxidant activity of the hot water-soluble polysaccharides from Anacyclus pyrethrum (L.) Lag.roots[J].Journal of Ethnopharmacology, 2021, 281:114491.
[20] 陈丽华, 单雅慧, 管咏梅, 等.药食同源物质改善胃肠道功能作用的研究进展[J].食品工业科技, 2023, 44(4):480-487. CHEN L H, SHAN Y H, GUAN Y M, et al.Research progress on the effect of medicinal and edible substances on improving gastrointestinal tract function[J].Science and Technology of Food Industry, 2023, 44(4):480-487.(in Chinese)
[21] 周剑, 马建苹, 田浩, 等.枸杞化学成分及生物活性研究进展[J].中国食品工业, 2019, 299(11):74-77. ZHOU J, MA J P, TIAN H, et al.Research progress on chemical constituents and biological activities of Lycium barbarum[J].China Food, 2019, 299(11):74-77.(in Chinese)
[22] 赵文竹, 张瑞雪, 于志鹏, 等.生姜的化学成分及生物活性研究进展[J].食品工业, 2016, 37(11):383-389. ZHAO W Z, ZHANG R X, YU Z P, et al.Research process in ginger chemical composition and biological activity[J].Food Industry, 2016, 37(11):383-389.(in Chinese)
[23] 谢占芳, 张倩倩, 朱凌佳, 等.菊花化学成分及药理活性研究进展[J].河南大学学报(医学版), 2015, 34(4):290-300. XIE Z F, ZHANG Q Q, ZHU L J, et al.Research progress on chemical constituents and pharmacological activities of Chrysanthemum morifolium[J].Journal of Henan University (Medical Edition), 2015, 34(4):290-300.(in Chinese)
[24] 袁书林.山药的化学成分和生物活性作用研究进展[J].食品研究与开发, 2008, 148(3):176-179. YUAN S L.Research advances on chemical compositions and bioactivites of Dioscorea opposita Thunb.(Chinese yam)[J].Food Research and Development, 2008, 148(3):176-179.(in Chinese)
[25] 袁红, 张淑芳, 贾绍辉, 等.黄芪生物活性及其在保健食品中的应用研究进展[J].食品科学, 2014, 35(15):330-334. YUAN H, ZHANG S F, JIA S H, et al.Progress in application and biological activity of Radix astragali in health foods[J].Food Science, 2014, 35(15):330-334.(in Chinese)
[26] 雷佳.海洋天然产物中吲哚类生物碱骨架化合物的合成[D].哈尔滨:哈尔滨商业大学, 2022. LEI J.Synthesis of indoles alkaloids skeleton compounds from marine natural products[D].Harbin:Harbin University of Commerce, 2022.(in Chinese)
[27] 王培培, 张真庆, 迟连利, 等.海洋动物来源糖胺聚糖生物活性研究进展[J].中国海洋药物, 2022, 41(5):82-90. WANG P P, ZHANG Z Q, CHI L L, et al.Advances in bioactivity of glycosaminoglycans derived from marine animals[J].Chinese Journal of Marine Drugs, 2022, 41(5):82-90.(in Chinese)
[28] 李海芳, 陈瑶, 杨梦照, 等.棘皮动物天然产物的研究进展[J].中国海洋药物, 2008, 4:52-59. LI H F, CHEN Y, YANG M Z, et al.Research progress of natural products of echinoderms[J].Chinese Journal of Marine Drugs, 2008, 4:52-59.(in Chinese)
[29] 赵丽, 吴光斌, 陈发河.海参多肽提取纯化及其生物活性研究进展[J].食品工业科技, 2019, 40(2):252-256. ZHAO L, WU G B, CHEN F H.Research progress on extraction, purification and biological activity of sea cucumber peptide[J].Science and Technology of Food Industry, 2019, 40(2):252-256.(in Chinese)
[30] CANKAŘOVÁ N, SCHVTZNEROVÁ E, KRCHŃÁK V.Traceless solid-phase organic synthesis[J].Chemical Reviews, 2019, 119(24):12089-12207.
[31] 杜磊.海参和海星脑苷脂抗肿瘤及改善癌症恶病质作用的研究[D].青岛:中国海洋大学, 2012. DU L.Study on anti-tumor activity and ameliorating cancer-associated cachexia effect of cerebrosides derived from Acaudina molpadioides and Asterias amurensis[D].Qingdao:Ocean University of China, 2012.(in Chinese)
[32] STONIK V A, KICHA A A, MALYARENKO T V, et al.Asterosaponins:Structures, taxonomic distribution, biogenesis and biological activities[J].Marine Drugs, 2020, 18(12):584.
[33] ESPAMER V, ROSEGHINI M, ENDEAN R, et al.Biogenic amines and active polypeptide in the skin of Australian amphibians[J].Nature, 1966, 212(5058):204.
[34] 余崇林, 杨品华, 李瑞祥.雨蛙素诱发的急性胰腺炎动物模型[J].解剖科学进展, 1999, 4:313-316. YU C L, YANG P H, LI R X.Animal models of lutherin-induced acute pancreatitis[J].Progress of Anatomical Sciences, 1999, 4:313-316.(in Chinese)
[35] 东芷萱.鸭胆膏中油脂、鹅去氧胆酸、别胆酸联合提取工艺研究[D].天津:天津科技大学, 2020. DONG Z X.Study on the combined extraction process of grease, chenodeoxycholic acid and allocholic acid in duck bile paste[D].Tianjin:Tianjin University of Science and Technology, 2020.(in Chinese)
[36] ZHANG X, ZHAO X, LIU K, et al.Bufalin:A systematic review of research hotspots and antitumor mechanisms by text mining and bioinformatics[J].American Journal of Chinese Medicine, 2020, 48(7):1633-1650.
[37] KAI S, LU J H, HUI P P, et al.Pre-clinical evaluation1 of cinobufotalin as a potential anti-lung agent[J].Biochemical and Biophysical Research Communications, 2014, 452(3):768-774.
[38] 李海营.华蟾毒它灵通过抑制HIF-1α介导的Warburg效应诱导肝癌细胞凋亡[D].开封:河南大学, 2020. LI H Y.Cinobufotalin induced hepatocellular carcinoma cell apoptosis through inhibition of HIF-1α-mediated Warburg effect[D].Kaifeng:Henan University, 2020.(in Chinese)
[39] 刘朋飞.麝香酮辅助骨髓间充质干细胞治疗大鼠急性肾损伤的作用研究[D].长春:吉林大学, 2016. LIU P F.Study on the assistant effect of muscone on the therapeutic actin of bone marrow-derived mesenchymal stem cell against acute kidney injury in rat[D].Changchun:Jilin University, 2016.(in Chinese)
[40] NEWMAN D J, CRAGG G M.Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019[J].Journal of Natural Products, 2020, 83(3):770-803.
[41] COCHRANE S A, VEDERAS J C.Lipopeptides from Bacillus and Paenibacillus spp.:A gold mine of antibiotic candidates[J].Medicinal Research Reviews, 2016, 36(1):4-31.
[42] 杨智宇.两株细菌中的新型天然产物挖掘研究[D].济南:山东大学, 2022. YANG Z Y.Mining of novel natural products from two strains of bacteria[D].Jinan:Shandong University, 2022.(in Chinese)
[43] BARKA E A, VATSA P, SANCHEZ L, et al.Taxonomy, physiology, and natural products of actinobacteria[J].Microbiology and Molecular Biology Reviews, 2015, 80(1):1-43.
[44] 王琪, 靳淑委, 杨军艳, 等.淫羊藿的抗氧化性能及其药用价值[J].中国饲料, 2020, 6:6-9. WANG Q, JIN S W, YANG J Y, et al.The antioxidant properties of epimedium and its medicinal value[J].China Feed, 2020, 6:6-9.(in Chinese)
[45] 高学勇, 林珊, 韩咪莎.淫羊藿苷对环磷酰胺诱导生精障碍大鼠下丘脑-垂体-睾丸轴的影响[J].解剖学杂志, 2018, 41(2):147-151. GAO X Y, LIN S, HAN M S.Effects of icariin on hypothalamus-pituitary-testicular axis of rat with impaired spermatogenesis induced by cyclophosphamide[J].Chinese Journal of Anatomy, 2018, 41(2):147-151.(in Chinese)
[46] XIA G, XIN N, LIU W, et al.Inhibitory effect of lycium barbarum polysaccharides on cell apoptosis and senescence is potentially mediated by the p53 signaling pathway[J].Molecular Medicine Reports, 2014, 9(4):1237-1241.
[47] HE W, LIU H, HU L, et al.Icariin improves testicular dysfunction via enhancing proliferation and inhibiting mitochondria-dependent apoptosis pathway in high-fat diet and streptozotocin-induced diabetic rats[J].Reproductive Biology and Endocrinology, 2021, 19(1):168.
[48] LUAN Y, CHEN Y, FENG Y, et al.Deciphering the myth of icariin and synthetic derivatives in improving erectile function from a molecular biology perspective:A narrative review[J].Translational Andrology and Urology, 2022, 11(7):1007-1022.
[49] 徐汉虹, 赖多, 张志祥.植物源农药印楝素的研究与应用[J].华南农业大学学报, 2017, 38(4):1-11. XU H H, LAI D, ZHANG Z X.Research and application of botanical pesticide azadirachtin[J].Journal of South China Agricultural University, 2017, 38(4):1-11.(in Chinese)
[50] 常丽, 李建军, 黄思齐, 等.植物大麻活性成分及其药用研究概况[J].生命的化学, 2018, 38(2):273-280. CHANG L, LI J J, HUANG S Q, et al.A review of active ingredients from Cannabis sativa L.and their medicinal potential[J].Chemistry of Life, 2018, 38(2):273-280.(in Chinese)
[51] MISHRA R K, SINGH S K.Effect of aqueous leaf extract of Azadirachta indica on the reproductive organs in male mice[J].Indian Journal of Experimental Biology, 2005, 43:1093-1103.
[52] DU PLESSIS S S, AGARWAL A, SYRIAC A.Marijuana, phytocannabinoids, the endocannabinoid system, and male fertility[J].Journal of Assisted Reproduction and Genetics, 2015, 32(11):1575-1588.
[53] TVRDÁ E, BENKO F, SLANINA T, et al.The role of selected natural biomolecules in sperm production and functionality[J].Molecules, 2021, 26(17):5196.
[54] MIRHOSEINI M, MOHAMADPOUR M, KHORSANDI L.Toxic effects of Carthamus tinctorius L.(Safflower) extract on mouse spermatogenesis[J].Journal of Assisted Reproduction and Genetics, 2012, 29(5):457-461.
[55] 陈永志, 姜月华, 孟宪卿, 等.刺蒺藜及其有效成分治疗心血管疾病研究进展[J].吉林中医药, 2016, 36(3):316-320. CHEN Y Z, JIANG Y H, MENG X Q, et al.Treatment of Tribulus terrestris L. and its active ingredients on cardiovascular diseases[J].Jilin Journal of Traditional Chinese Medicine, 2016, 36(3):316-320.(in Chinese)
[56] ARIYAN F, FARSHAD A, ROSTAMZADEH J.Protective effects of Tribulus terrestris and Cinnamomum zeylanicum extracts and trehalose added to diluents on goat epididymal sperm freezability[J].Cryobiology, 2021, 98:172-180.
[57] 寇秋爱, 夏立营, 刘秋霞, 等.马鹿茸淫羊藿复合物辅助改善精子活力[J].食品工业, 2023, 44(8):143-146. KOU Q A, XIA L Y, LIU Q X, et al.Cervus elaphus Linnaeus and epimedium complex in sperm motility[J].Food Industry, 2023, 44(8):143-146.(in Chinese)
[58] STAICU F D, LOPEZ-UBEDA R, ROMERO-AGUIRREGOMEZCORTA J, et al.Regulation of boar sperm functionality by the nitric oxide synthase/nitric oxide system[J].Journal of Assisted Reproduction and Genetics, 2019, 36(8):1721-1736.
[59] MORRIS S M.Arginine metabolism revisited[J].Journal of Nutrition, 2016, 146(12):2579-2586.
[60] 袁彦波.棉酚致小鼠睾丸生精细胞凋亡及Bax、Bcl-2表达相关性研究[D].哈尔滨:东北农业大学, 2015. YUAN Y B.The correlations study of gossypol on testicular spermatogenic cell apoptosis and expression of Bax, Bcl-2 in mouse[D].Harbin:Northeast Agricultural University, 2015.(in Chinese)
[61] BABATUNDE D J, TOPE O O, FIDELIS O E, et al.Extract of Adansonia digitata reversed cotton seed extract-induced testicular damage in Wistar rats[J].Journal of Experimental & Clinical Assisted Reproduction, 2021, 25(2):257-265.
[62] AVERSA A, FABBRI A.New oral agents for erectile dysfunction:What is changing in our practice?[J].Asian Journal of Andrology, 2001, 3:175-179.
[63] GAUTHAMAN K, ADAIKAN P G, PRASAD R N.Aphrodisiac properties of Tribulus terrestris extract (Protodioscin) in normal and castrated rats[J].Life Sciences, 2002, 71:1385-1396.
[64] SMERIGLIO A, TROMBETTA D, MARCOCCIA D, et al.Intracellular distribution and biological effects of phytochemicals in a sex steroid-sensitive model of human prostate adenocarcinoma[J].Anti-Cancer Agents in Medicinal Chemistry, 2014, 14:1386-1396.
[65] YU J, ETO M, AKISHITA M, et al.Signaling pathway of nitric oxide production induced by ginsenoside Rb1 in human aortic endothelial cells:A possible involvement of androgen receptor[J].Biochemical and Biophysical Research Communications, 2007, 353:764-769.
[66] LUO L L, HUANG J, FU Y C, et al.Effects of tea polyphenols on ovarian development in rats[J].Journal of Endocrinological Investigation, 2008, 31(12):1110-1118.
[67] WU Y, WANG Z, DU Q, et al.Pharmacological effects and underlying mechanisms of licorice-derived flavonoids[J].Evidence-based Complementary and Alternative Medicine, 2022, 2022:9523071.
[68] SELYUTINA O Y, POLYAKOV N E.Glycyrrhizic acid as a multifunctional drug carrier-from physicochemical properties to biomedical applications:A modern insight on the ancient drug[J].International Journal of Pharmaceutics, 2019, 559:271-279.
[69] KONG X X, FU Y C, XU J J, et al.Resveratrol, an effective regulator of ovarian development and oocyte apoptosis[J].Journal of Endocrinological Investigation, 2011, 34(11):e374-e381.
[70] 刘宗易, 彭明利.姜黄素类化合物的研究进展[J].药学研究, 2022, 41(10):673-677. LIU Z Y, PENG M L.Research progress of curcumin compounds[J].Journal of Pharmaceutical Research, 2022, 41(10):673-677.(in Chinese)
[71] CHEN C C, CHAN W H.Injurious effects of curcumin on maturation of mouse oocytes, fertilization and fetal development via apoptosis[J].International Journal of Molecular Sciences, 2012, 13(4):4655-4672.
[72] HUANG C H, CHAN W H.Protective effects of liquiritigenin against citrinin-triggered, oxidative-stress-mediated apoptosis and disruption of embryonic development in mouse blastocysts[J].International Journal of Molecular Sciences, 2017, 18(12):2538.
[73] CHEN C C, HSIEH M S, HSUUW Y D, et al.Hazardous effects of curcumin on mouse embryonic development through a mitochondria-dependent apoptotic signaling pathway[J].International Journal of Molecular Sciences, 2010, 11(8):2839-2855.
[74] 魏莹晖.皮质酮对小鼠卵巢卵泡发育及卵巢颗粒细胞LHR表达的影响及机制[D].南京:南京农业大学, 2020. WEI Y H.Corticosterone regulates the development of mouse ovarian follicles and the expression of LHR in ovarian granulosa cells[D].Nanjing:Nanjing Agricultural University, 2020.(in Chinese)
[75] CHOU C H, CHEN M J.The effect of steroid hormones on ovarian follicle development[J].Vitamins and Hormones, 2018, 107:155-175.
[76] 康岚, 李娜, 姜大成.林蛙油的雌激素样作用研究[J].现代食品科技, 2015, 31(8):25-30. KANG L, LI N, JIANG D C.Estrogen-like effects of oviductus ranae[J].Modern Food Science & Technology, 2015, 31(8):25-30.(in Chinese)
[77] 赵宏宇, 王玉, 刘新宇, 等.林蛙油提升雌激素的机制研究[J].食品工业科技, 2019, 40(19):296-300. ZHAO H Y, WANG Y, LIU X Y, et al.Study on mechanism of Oviductus ranae promoting estrogen[J].Science and Technology of Food Industry, 2019, 40(19):296-300.(in Chinese)
[78] KHEZRI S, ALIHEMMATI A, ABEDELAHI A.Genistein blunted detrimental effects of polycystic ovary syndrome on the ovarian tissue of rats by improving follicular development and gonadotropin secretion[J].Jornal Brasileiro de Reproducao Assistida, 2022, 26(3):379-386.
[79] SHOOREI H, KHAKI A, AINEHCHI N, et al.Effects of Matricaria chamomilla extract on growth and maturation of isolated mouse ovarian follicles in a three-dimensional culture system[J].Chinese Medical Journal, 2018, 131(2):218-225.
[80] 杨艳, 韦炎龙, 方峰.丹参中活性成分在心血管疾病中的研究进展[J].中医临床研究, 2020, 12(21):37-40. YANG Y, WEI Y L, FANG F.Advances in the mechanism of Salvia miltiorrhiza against cardiovascular disease[J].Clinical Journal of Chinese Medicine, 2020, 12(21):37-40.(in Chinese)
[81] MAO C, ZHANG Y, ZHANG Y, et al.The effect of tanshinone IIA on the cardiovascular system in ovine fetus in utero[J].The American Journal of Chinese Medicine, 2009, 37(6):1031-1044.
[82] SUN M H, LI X H, XU Y, et al.Citrinin exposure disrupts organelle distribution and functions in mouse oocytes[J]. Environmental Research, 2020, 185:109476.
[83] O'CONNELL A A, ABDALLA T E, RADULOVICH A A, et al.Curcumin supplementation and endometrial lining:Examining the role and pathophysiology of use during frozen-thawed embryo transfer[J].Cureus Journal of Medical Science, 2021, 13(12):e20415.