精子发生及冷冻过程中表观遗传调控的研究进展

摘要/Abstract

摘要： 表观遗传调控是不涉及DNA序列改变而引起基因可遗传变化的机制，包括组蛋白修饰、非编码RNAs的调控及DNA特定碱基结构的修饰，它在基因表达过程中起着十分重要的作用。在精子发生过程中，机体通过表观遗传修饰从而确保精子具有正常的功能。冷冻过程会造成精子不可逆的损伤，这些冷冻损伤可能与精子表观遗传变化有关。作者对精子发生及冷冻保存过程中的表观遗传调控机制进行了综述。

关键词: 精子发生; 冷冻保存; 表观遗传调控

Abstract: Epigenetics modification is the heritable changes in gene activity which are not involved in changes in the DNA sequences, including DNA methylation and chromatin remodeling, histone modification and non-coding RNAs, which plays important roles in gene expression, spermatogenesis, development and maturation. During spermatogenesis, normal morphology, motility and fertility were proven to be modulated by epigenetic changes. Cryopreservation causes dramatic changes of the sperm viability, motility and fertility, and the cryoinjury might be involved in some epigenetic factors. The epigenetic modifications involved in spermatogenesis and cryopreservation and their relationship were reviewed.

Key words: spermatogenesis; cryopreservation; epigenetic modification

中图分类号:

S814.8

彭文培, 曾长军. 精子发生及冷冻过程中表观遗传调控的研究进展[J]. 中国畜牧兽医, 2014, 41(9): 199-205.

PENG Wen-pei, ZENG Chang-jun. Research Progress on Epigenetic Modifications during Spermatogenesis and Cryopreservation[J]. , 2014, 41(9): 199-205.

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