鲍曼不动杆菌毒力因子研究进展

中国畜牧兽医

鲍曼不动杆菌毒力因子研究进展

邹德颖，刘东，郭兴，陈晓峰，胡盼，卢士英，周玉，柳增善，任洪林

（人兽共患病研究教育部重点实验室，吉林大学人兽共患病研究所，吉林大学动物医学学院，吉林长春 130062）

收稿日期:2013-08-21 出版日期:2014-03-20 发布日期:2014-05-15
通讯作者: 卢士英（1973—），女，吉林人，博士，副教授，研究方向：兽医公共卫生。Tel：0431-87836716；E-mail:lushiying1129@163.com 任洪林（1974—），男，博士，副教授，研究方向：兽医公共卫生、人兽共患细菌病学。Tel:0431-87836716；E-mail：renhl@jlu.edu.cn
作者简介:邹德颖（1988—），女，内蒙古人，硕士生，研究方向：兽医公共卫生、预防兽医学。

Research Progress on Virulence Factors of Acinetobacter baumannii

ZOU De-ying, LIU Dong, GUO Xing, CHEN Xiao-feng, HU Pan, LU Shi-ying, ZHOU Yu,LIU Zeng-shan, REN Hong-lin

(Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis,College of Veterinary Medicine, Jilin University, Changchun 130062, China)

Received:2013-08-21 Online:2014-03-20 Published:2014-05-15

摘要/Abstract

摘要： 鲍曼不动杆菌(Acinetobacter baumannii)是一种广泛分布于人类生活环境中的重要的条件致病菌，由于具有较强的抗药性，一直是生物医学领域中的研究热点。相对于抗药性的研究，对于毒力因子的了解就知之甚少。鲍曼不动杆菌入侵宿主后，可以在宿主体内长期存活，同时引起宿主细胞的严重损害，因此其毒力因子可能在入侵、增殖、杀伤过程中发挥重要作用。作者综述了近几年国内外关于鲍曼不动杆菌主要毒力因子的研究进展，以便于研究人员进一步了解鲍曼不动杆菌的致病机制，同时为治疗疾病和筛选药物提供新思路。

关键词: 鲍曼不动杆菌; 毒力因子; 致病机制

Abstract: Acinetobacter baumannii is an important condition opportunistic pathogen widely distributing in human living environment. Because of its strong drug-resistant character, it has always been a hot topic in the biomedical research field. However, little knowledge of its virulence factors is known comparing to the drug-resistance research. Acinetobacter baumannii can survive for a long time in host and cause serious damage to host cells after invading the host, so virulence factors might play an important role during the invasion, proliferation and injure process. Here, we summarized the advanced researches and progresses on virulence factors of Acinetobacter baumannii for benefiting future study of its pathogenic mechanisms, providing new ideas for the potential treatment and screening drugs of diseases caused by Acinetobacter baumannii.

Key words: Acinetobacter baumannii; virulence factors; pathogenic mechanism

邹德颖，刘东，郭兴，陈晓峰，胡盼，卢士英，周玉，柳增善，任洪林. 鲍曼不动杆菌毒力因子研究进展[J]. 中国畜牧兽医.

ZOU De-ying, LIU Dong, GUO Xing, CHEN Xiao-feng, HU Pan, LU Shi-ying, ZHOU Yu,LIU Zeng-shan, REN Hong-lin. Research Progress on Virulence Factors of Acinetobacter baumannii[J]. .

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