1 Bouchama A,Parhar R S,el-Yazigi A,et al. Endotoxemia and release of tumor necrosis factor and interleukin 1 alpha in acute heatstroke[J].J Appl Physiol,1991,70(6):2640~2644. 2 Boushey R P,Yusta B,Drucker D J. Glucagon-like peptide (GLP)-2 reduces chemotherapy-associated mortality and enhances cell survival in cells expressing a transfected GLP-2 receptor[J].Cancer Res,2001,61(2): 687~693. 3 Brock-Utne J G,Gaffin S L,Wells M T,et al. Endotoxaemia in exhausted runners after a long-distance race[J].S Afr Med J,1988,73(9):533~536. 4 Burrin D G,Stoll B,Guan X,et al. Glucagon-like peptide 2 dose-dependently activates intestinal cell survival and proliferation in neonatal piglets[J].Endocrinology,2005,146(1):22~32. 5 Cameron H L,Perdue M H. Stress impairs murine intestinal barrier function: Improvement by glucagon like peptide-2[J].J Pharmacol Exp Ther,2005,314(1):214~220. 6 Chen X,Zhao H X,Fu X S,et al. Glucagon like peptide 2 protects intestinal barrier in severe acute pancreatitis through regulating intestinal epithelial cell proliferation and apoptosis[J].Pancreas,2012,41(7):1080~1085. 7 Dokladny K,Moseley P L,Ma T Y. Physiologically relevant increase in temperature causes an increase in intestinal epithelial tight junction permeability[J].Am J Physiol Gastrointest Liver Physiol,2006,290(2):G204~G212. 8 Dokladny K,Ye D,Kennedy J C,et al.Cellular and molecular mechanisms of heat stress-induced up-regulation of occluding protein expression: Regulatory role of heat shock factor-1[J].Am J Pathol,2008,172(3):659~670. 9 Dugan M E R,McBurney M I.Luminal glutamine perfusion alters endotoxin-related changes in ileal permeability of the piglet[J].Journal of Parenteral and Enteral Nutrtion,1995,19(1):83~87. 10 Evans M E,Jones D P,Ziegler T R. Glutamine inhibits cytokine-induced apoptosis in human colonic epithelial cells via the pyrimidine pathway[J].Am J Physiol Gastrointest Liver Physiol,2005,289(3):G388~G396. 11 Ghatei M A,Goodlad R A,Taheri S,et al. Proglucagon-derived peptides in intestinal epithelial proliferation: Glucagon-like peptide-2 is a major mediator of intestinal epithelial proliferation in rats[J].Dig Dis Sci,2001,46(6):1255~1263. 12 Groot J,Bijlsma P,Van Kalkeren A,et al.Stress-induced decrease of the intestinal barrier function:The role of muscarinic receptor activation[J].Annals of the New York Academy of Sciences,2000,915:237~246. 13 Gwodzdz B,Dyduch A,Grzybek H,et al.Structural changes in brain mitochondria of mice subjected to hyperthermia[J].Exp Pathol,1978,15(2):124~126. 14 Hall D M,Buettner G R,Oberley L W,et al. Mechanism of circulatory and intestinal barrier dysfunction during whole body hyperthermia[J].Am J of Physiol: Heart and Circ Physiol,2001,280(2):H509~H521. 15 Jarasch E D,Bruder G,Heid H W. Significance of xanthine oxidase in capillary endothelial cell[J].Acta Physiol Scand,1986,548:39~46. 16 Kregel K C,Wall P T,Gisolfi C V. Peripheral vascular responses to hyperthermia in the rat[J].J Appl Physiol,1988,64(6):2582~2588. 17 Lambert G P,Gisolfi C V,Berg D J,et al. Selected contribution: Hyperthermia-induced intestinal permeability and the role of oxdative and nitrosative stress[J].J Appl Physiol,2002,92(4):1750~1761. 18 Lambert G P,Lang J, Bull A,et al.Fluid restriction during running increases GI permeablility[J].Int J Sports Med,2008,29(3):194~198. 19 Marchbank T,Davision G,Oakes J R,et al.The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes[J].Am J Physiol Gastrointest Liver Physiol,2011,300(3):G477~G484. 20 Matsuo K,Zhang X,Ono Y,et al. Acute stress-induced colonic tissue HSP70 expression requires commensal bacterial components and intrinsic glucocorticoid[J].Brain Behav Immun,2009,23(1):108~115. 21 Mazzon E,Sturniolo G C,Puzzolo D,et al. Effect of stress on the paracellular barrier in the rat ileum[J].Gut,2002,51(4):507~513. 22 Mazzon E,Cuzzovrea S. Role of TNF-alpha in ileum tight junction alteration in mouse model of restraint stress[J].Am J Physiol Gastrointest Liver Physiol,2008,294(5):G1268~G1280. 23 Mazzon E,Crisafulli C,Galuppo M,et al. Role of peroxisome proliferator-activated receptor-alpha in ileum tight junction alteration in mouse model of restraint stress[J].Am J Physiol Gastrointest Liver Physiol,2009,297(3): G488~G505. 24 McCarthy K M,Skare I B,Stankewich M C,et al.Occluding is a functional component of the tight junction[J].J Cell Sci,1996,109(9):2287~2298. 25 Meddings J B,Swain M G. Environmental stress-induced gastrointestinal permeability is mediated by endogenous glucocorticoids in the rats[J].Gastroenterology,2000,119(4):1010~1028. 26 Moseley P L,Gisolfi C V. New frontiers in thermoregulation and exercise[J].Sports Med,1993,16(3):163~167. 27 Moseley P L,Gapen C,Wallen E S,et al. Thermal stress induces epithelial permeability[J].Am J Physiol,1994,267(2):C425~C434. 28 Neu J. Gastrointestinal maturation and implications for infant feeding[J].Early Hum Dev,2007,83(12): 767~775. 29 Newsholme P. Why is L-glutamine metabolism important to cells of the immune system in healthy,postinjury,surgery or infection?[J].J Nutr,2001,131(9):S2515~S2522. 30 Otte J A,Oostveen E,Geelkerken R H,et al. Exercise induces gastric ischemia in healthy volunteers: A tonometry study[J].J Appl Physiol,2001,91(2):866~871. 31 Playford R J,Floyd D N,Macdonald C E,et al. Bovine colostrum is a health food supplement which prevent NSAID induced gut damage[J].Gut,1999,44(5):653~658. 32 Playford R J,Macdonald C E,Calnan D P,et al. Co-administration of the health food supplement,bovine colostrum,reduces the acute nonsteroidal anti-inflammatory drug-induced increase in intestinal permeability[J].Clin Sci,2001,100(6):627~633. 33 Prosser C,Stelwagen K,Cummins R,et al. Reduction in heat-induced gastrointestinal hyperpermeability in rats by bovine colostrum and goat milk powders[J].J Appl Physiol,2004,96(2):650~654. 34 Rokutan K. Role of heat shock proteins in gastric mucosal protection[J].J Gastroenterol Hepatol,2000,15:D12~D19. 35 Ruell P A,Hoffman K M,Chow C M,et al. Effect of temperature and duration of hyperthermia on HSP72 induction in rat tissues[J].Mol Cell Biochem,2004,267(1~2):187~194. 36 Salzman A,Wollert P S,Wang H,et al. Intralunimal oxygenation ameliorates ischemia/reperfusioni-indued gut mucosal hyperpermeability in pigs[J].Circ Shock,1993,40(1):37~46. 37 Sanderson I R. Short chain fatty acid regulation of signaling genes expressed by the intestinal epithelium[J].J Nutr,2004,134(9):S2450~S2454. 38 Saunders P R,Hanssen N P,Perdue M H. Cholinergic nerves mediate stress-induced intestinal transport abnormalities in Wistar-Kyoto rats[J].Am J Physiol,1997,273(2):G486~G490. 39 Saunders P R,Santos J,Hanssen N P,et al. Physical and psychological stress in rats enhances colonic epithelial permeability via peripheral CRH[J].Dig Dis Sci,2002,47(1):208~215. 40 Sawka M N,Young A J,Francesconi R P,et al. Thermoregulatory and blood responses during exercise at graded hypohydration levels[J].J Appl Physiol,1985,59(5):1394~1401. 41 Scheppach W,Dusel G,Kuhn T,et al. Effect of L-glutamine and n-butyrate on the restitution of rat colonic mucosa after acid induced injury[J].Gut,1996,38(6):878~885. 42 Shapiro Y,Alkan M,Epstein Y,et al. Increase in rat intestinal permeability to dendotoxin during hyperthermia[J].Eur J Appl Physiol Occup Physiol,1986,55(4):410~412. 43 Singleton K D,Wischmeyer P E. Oral glutamine enhances heat shock protein expression and improves survival following hyperthermia[J].Shock,2006,25(3):295~299. 44 Soderholm J D,Perdue M H. Stress and the gastrointestinal tract Ⅱ.Stress and intestinal barrier function[J].Am J Physiol Gastrointest Liver Physiol,2001,280(1):G7~G13. 45 van Hooijdonk A C,Kussendrager K D,Steijns J M. In vivo antimicrobial and antiviral activity of components in bovine milk and colostrum involved in non-specific defence[J].Br J Nutr,2000,84(Suppl.1):S127~S134. 46 Welsh M J,Shasby D M,Husted R M,et al. Oxidants increase paracellular permeability in a cultured epithelial cell line[J].J Clin Invest,1985,76(3):1155~1168. 47 Wu G Y,Field C J,Marliss E B. Glutamine and glucose metabolism in rat splenocytes and mesenteric lymph mode lymphocytes[J].Am J Physio,1991,260(1):E141~E147. 48 Xu D Z,Lu Q,Kubicka R,et al. The effect of hypoxia/reoxygenation on the cellular function of intestinal epithelial cells[J].J Trauma,1999,46(2):280~285. 49 Yoshitake S,Noguchi T,Hoashi S,et al. Changes in intramucosal pH and gut blood flow during whole body heating in a porcine model[J].Int J Hyperthermia,1998,14(3):285~291. |