简单异尖线虫过敏症研究进展

摘要/Abstract

摘要： 简单异尖线虫广泛存在于海洋动物并呈全球性分布,人因食用含有该线虫幼虫的生鱼或未煮熟的鱼产品而发生感染,其所引起的临床症状与虫体在消化道所处位置相关,主要引起肠黏膜水肿等过敏性症状。文章综述了该症流行病学、病理变化、症状、诊断、抗原、过敏原和预防措施等方面内容。

关键词: 鱼; 异尖线虫; 异尖线虫病; 交叉反应; 食品过敏

Abstract: Anisakis simplex is a worldwide-distributed nematode that infects consumers of raw or under-cooked fish. The clinical signs of anisakiasis depend on the place in the digestive tract where the larva is deposited. Symptoms develop as a result of an inflammatory condition occurring in the gastric wall mucosa when the larva enters it. This paper deals with the recent advances in Anisakis simplex allergy which contains prevalence,clinical issues and diganoses,antigen and allergens,bases for prevention and conclusions.

Key words: fish; Anisakis; anisakiasis; cross-reactivity; food allergy

中图分类号:

李孝军, 耿新辉, 陈宇, 唐行忠, 洪青林. 简单异尖线虫过敏症研究进展[J]. , 2012, 39(6): 185-188.

LI Xiao-jun, GENG Xin-hui, CHEN Yu, TANG Xing-zhong, HONG Qing-lin. Recent Advances in Anisakis simplex Allergy[J]. , 2012, 39(6): 185-188.

参考文献

1 Arrieta I,del Barrio M,Vidarte L,et al.Molecular cloning and characterization ofan IgE-reactive protein from Anisakis simplex: Ani s 1[J].Mol Biochem Parasitol,2000,107:263~268.
2 Asturias J A, Eraso E,Martinez A.Cloning and high level expression in Escherichia coli of an Anisakis simplex tropomyosin isoform[J].Mol Biochem Parasitol,2000,108:263~267.
3 Baeza M L,Zubeldia J M,Rubio M.Anisakis simplex allergy[J].ACI Int,2001,13:242~249.
4 Caballero M L, Umpierrez A, Moneo I,et al.Ani s 10,a new Anisakis simplex allergen: cloning and heterologous expression[J].Parasitol Int,2011,60(2):209~212.
5 Choi S J,Lee J C,Kim M J,et al.The clinical characteristics of Anisakis allergy in Korea[J].Korean J Intern Med,2009,24:160~163.
6 Daschner A,Alonso-Gómez A,Caballero M T,et al.Usefulness of early serial measurement of specific and total immunoglobulin E in the diagnosis of gastro-allergic anisakiasis[J].Clin Exp Allergy,1998,29:1260~1264.
7 Daschner A,Alonso-Gomez A,Carbanas R,et al.Gastroallergic anisakiasis:borderline between food allergy and parasitic diseaseclinical and allergologic evaluation of 20 patients with confirmed acuteparasitism by Anisakis simplex[J].J Allergy Clin Immunol,2000,105:176~181.
8 Dominguez O J,Cimarra M,Sevilla M,et al.Anisakis simplex:a cause of intestinal pseudo-obstruction[J].Rev Esp Enferm Dig,2000,92:132~139.
9 Fernandez C E,Quirce S,Maranon F,et al. Allergenic cross-reactivity between third stage larvae of Hysterothylacium aduncum and Anisakis simplex[J].J Allergy Clin Immunol,1998,101:554~555.
10 Johansson E,Apponno M,Lundberg M,et al.Allergenic cross-reactivity between the nematode Anisakis simplex and the dust mites Acarus siro,Lepidoglyphus destructor,Tyrophagus putrescientae,and Dermatophagoides pteronyssinus[J].Allergy,2001,56:660~666.
11 Kasuya S,Koga K.Significance of detection of specific IgE in Anisakis related diseases[J].Aerugi,1992,41:106~110.
12 Kobayashi Y,Ishizaki S,Shimakura K,et al.Molecular cloning and expression of two new allergens from Anisakis simplex[J].Parasitol Res,2007,100:1233~1241.
13 Kobayashi Y,Ohsaki K,Ikeda K,et al.Identification of novel three allergens from Anisakis simplex by chemiluminescent immunoscreening of an expression cDNA library[J].Parasitol Int,2011,60(2):144~150.
14 Kobayashi Y,Shimakura K,Ishizaki S,et al.Purification and cDNA cloning of a new heat-stable allergen from Anisakis simplex[J].Mol Biochem Parasitol,2007,155:138~145.
15 Lopez-Serrano M C,Alonso G A,Daschner A,et al.Gastroallergic anisakiasis: findings in 22 patients[J].J Gastroenterol Hepatol,2000,15:503~506.
16 Lorenzo S,Iglesias R,Leiro J,et al.Usefulness of currently available methods for the diagnosis of Anisakis simplex allergy[J].Allergy,2000,55:627~633.
17 Moneo I,Audicana M T,Alday E,et al.Periodate treatment of Anisakis simplex allergens[J].Allergy,1997,52:565~569.
18 Moneo I,Caballero M L,Gómez F,et al.Isolation and character-ization of a major allergen from the fish parasite Anisakis simplex[J].J Allergy Clin Immunol,2000,106:177~182.
19 Moneo I,Caballero M L,González-Muňoz M,et al.Isolation of a heat- resistant allergen from the fish parasite Anisakis simplex[J].Parasitol Res,2005,96:285~289.
20 Nawa Y,Hatz C,Blum J.Sushi delights and parasites:the risk of fishborne and foodborne parasitic zoonoses in Asia[J].Clin Infect Dis,2005,41:1297~1303.
21 Perez J,Fern andez-Caldas E,Maranon F,et al.Molecular cloning of paramyosin,a new allergen of Anisakis simplex[J].Int Arch Allergy Immunol,2000,123:120~129.
22 Rodríguez E,Anadón A M,García-Bodas E,et al.Novel sequences and epitopes of diagnostic value derived from the Anisakis simplex Ani s 7 major allergen[J]. Allergy, 2008,63(2):219~225.
23 Rodriguez-Perez R,Moneo I,Rodriguez Mahillo A,et al.Cloning and expression of Ani s 9,a new Anisakis simplex allergen[J].Mo1 Biochem Parasitol,2008,159:92~97.
24 Scala E, Giani M, Pirrotta L,et al.Occupational generalized urticaria and allergic airbone asthma due to Anisakis simplex[J].Eur J Dermatol,2001,11:249~250.
25 Toro C,Caballero M L,Baquero M,et al.High prevalence of seropositivity to a major allergen of Anisakis simplex, Ani s 1, in dyspeptic patients[J].Clin Diagn Lab Immunol,2004,11(1):115~118.
26 Valls A,Pascual C Y,Martín E M.Anisakis allergy:an update[J].Revue Franaise d’Allergologie et d'Immunologie Clinique,2005,45:108~113.

[1]	施金谷, 黄珊珊, 黄基伟, 陈坤海, 胡大胜, 朱志雄, 韩书煜. 高温胁迫下罗非鱼源无乳链球菌的比较转录组分析[J]. 中国畜牧兽医, 2023, 50(6): 2207-2216.
[2]	刘馨, 潘吉脉, 胡安东, 曾成容, 杨颖, 程振涛, 陈江凤, 姜海波, 文明. 黄芪多糖对杂交鲟用嗜水气单胞菌灭活疫苗的影响[J]. 中国畜牧兽医, 2023, 50(3): 1177-1184.
[3]	杨泽敏, 李双, 金正雨, 廖义潇, 杨颖, 文明. 1株鲤鱼源植物乳杆菌的分离鉴定及其生物学特性分析[J]. 中国畜牧兽医, 2022, 49(7): 2805-2811.
[4]	李祥, 何金环, 潘春梅, 索江华, 李京. 丁酸钠对鱼类肠道消化吸收的影响研究进展[J]. 中国畜牧兽医, 2022, 49(1): 131-139.
[5]	陈怀君, 郭长明, 朱善元, 吴植, 袁圣, 王永娟, 袁橙, 潘勇, 王晓晔. 海南罗非鱼源无乳链球菌的分离鉴定及生物学特性研究[J]. 中国畜牧兽医, 2021, 48(8): 3058-3068.
[6]	郭长明, 陈怀君, 袁橙, 罗福广, 黄德生, 贾国华, 袁圣, 朱善元. 广西罗非鱼无乳链球菌的分离鉴定、毒力基因及耐药性研究[J]. 中国畜牧兽医, 2021, 48(7): 2607-2616.
[7]	何文娜, 肖婷, 何颖, 周英宁, 蒋冬福, 卢敬专, 陈忠伟, 胡庭俊. 贞苓增免散对罗非鱼的安全性评价[J]. 中国畜牧兽医, 2021, 48(11): 4004-4013.
[8]	赵怡, 文露婷, 黄姻, 陈忠, 刘倩, 林勇, 胡庭俊. 山豆根多糖对罗非鱼生长性能和免疫功能的影响[J]. 中国畜牧兽医, 2021, 48(10): 3635-3643.
[9]	袁向芬, 吴绍强, 林祥梅, 吕继洲. 高通量测序分析5例进口鱼粉鱼源性成分构成[J]. 中国畜牧兽医, 2021, 48(1): 93-100.
[10]	张欣, 潘晨浩, 赵瑞利, 姜轩, 金天明, 赵洋, 马吉飞, 于恩远, 李留安, 张振洲, 李桂霞, 李瑞忠. 抗菌肽Temprine-La(FS)抑制2型猪链球菌生物被膜形成的研究[J]. 中国畜牧兽医, 2021, 48(1): 324-337.
[11]	张飘, 胡安东, 杨霞, 潘吉脉, 刘妍罕, 曾茂芹, 程振涛, 姜海波, 文明. 3株维氏气单胞菌耐药性及毒力基因的比较[J]. 中国畜牧兽医, 2020, 47(9): 2979-2987.
[12]	张飘, 胡安东, 杨霞, 潘吉脉, 姜海波, 文明. 一株草鱼维氏气单胞菌的分离鉴定及毒力基因分析[J]. 中国畜牧兽医, 2020, 47(3): 848-855.
[13]	郭文静, 王天玉, 王国栋, 吴盼红, 贺鑫晋, 陈剑杰, 曹谨玲, 罗永巨. 芝麻素对氟暴露斑马鱼生长性能及肠组织形态学的影响[J]. 《中国畜牧兽医》, 2019, 46(8): 2338-2345.
[14]	胡安东, 张明洋, 张飘, 杨霞, 程振涛, 姜海波, 文明. 鲤源嗜水气单胞菌分离鉴定、耐药性及毒力基因检测[J]. 《中国畜牧兽医》, 2019, 46(7): 2167-2175.
[15]	张楠驰, 方庆, 王利. 一株门多萨假单胞菌的分离鉴定及药物敏感性分析[J]. 《中国畜牧兽医》, 2019, 46(6): 1832-1840.