长链脂酰CoA合成酶(ACSL)的研究进展

摘要/Abstract

摘要： 长链脂酰CoA合成酶(long-chain acyl-CoA synthetase,ACSL)属于多基因家族编码的酶,在体内催化合成脂酰CoA是哺乳动物利用脂肪酸的第一步反应,因此ACSL在脂肪代谢中起着重要作用。作者从ACSL家族的命名和分类、ACSL基因表达对脂肪代谢的影响、不同ACSL对底物的选择性、转录调控因子对ACSL的调控及当前家畜ACSL的相关研究进展等方面进行了综述,并对今后ACSL研究的重点及意义进行了展望。

关键词: ACSL; 脂肪代谢; 基因表达; 家畜

Abstract: Long chain acyl-CoA synthetases (ACSLs) are encoded by a multi-gene family. Synthesis of acyl-CoA catalyzed by acyl-CoA synthetase (ACS) is the first step in mammalian response to the use of fatty acids,so ACSL in fat metabolism plays a major role. In this review,we cover the nomenclature and classing of the ACSL family,the expression of ACSL gene influencing on fat metabolism,the selectivity of different ACSL family on substrate,the regulation of ACSL gene expression by different transcription factors,and the current research related to livestock ACSL. We also put forward the future research focus and research significance about the ACSL family.

Key words: ACSL; fat metabolism; gene expression; livestock

中图分类号:

Q552

李庆岗, 陶著, 杨玉增, 张博, 史利华, 班冬梅, 张浩. 长链脂酰CoA合成酶(ACSL)的研究进展[J]. , 2012, 39(6): 137-140.

LI Qing-gang, TAO Zhu, YANG Yu-zeng, ZHANG Bo, SHI Li-hua, BAN Dong-mei, ZHANG Hao. Research Progress of Long Chain Acyl-CoA Synthetase[J]. , 2012, 39(6): 137-140.

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