半乳糖凝集素1蛋白及其生物学功能

›› 2012, Vol. 39 ›› Issue (6): 141-145.

半乳糖凝集素1蛋白及其生物学功能

秦欣欣^1,2, 孙红梅², 赵海平², 褚文辉², 王大涛², 李春义²

1. 江苏科技大学,江苏镇江 212018;
2. 中国农业科学院特产研究所,吉林省特种经济动物分子生物学国家重点实验室, 农业部特种经济动物遗传育种与繁殖重点实验室,吉林省特种经济动物分子生物学重点实验室,吉林吉林 132109

收稿日期:2011-11-07 出版日期:2012-06-20 发布日期:2012-07-02
通讯作者: 李春义(1959－),男,博士生导师,研究员,从事鹿茸生长发育机制与鹿茸基因工程学研究。E-mail:tcslichunyi@126.com E-mail:tcslichunyi@126.com
作者简介:秦欣欣(1984－),女,山东人,硕士,研究方向:鹿茸分子生物学。
基金资助:
973前期研究专项(2011CB111515);国家自然科学基金(31170950);吉林省自然科学基金(20101575)。

Research Progress on Galectin-1 and its Biological Functions

QIN Xin-xin^1,2, SUN Hong-mei², ZHAO Hai-ping², CHU Wen-hui², WANG Da-tao², LI Chun-yi²

1. Jingsu University of Science and Technology,Zhenjiang 212018,China;
2. Key Laboratory of Special Economic Animal Molecular Biology,Key Laboratory of Special Economic Animal Genetic Breeding and Reproduction, Ministry of Agriculture,Jilin Province State Key Laboratory of Special Economic Animal Molecular Biology, Institute of Special Wild Economic Animals and Plants,Chinese Academy of Agricultural Sciences,Jilin 132109,China

Received:2011-11-07 Online:2012-06-20 Published:2012-07-02

摘要/Abstract

摘要： 半乳糖凝集素1(Galectin-1)是一种分子质量约为14 ku的β-糖结合蛋白,是动物凝集素家族的成员之一。作为多种癌症的诊断指标,治疗癌症的新突破口,对Galectin-1的研究备受关注。此外,Galectin-1分布广泛,与多种正常生物功能相关,如细胞生长、神经修复、血管再生、软骨形成等。现阶段,关于Galectin-1在鹿茸再生中的研究很少,但鹿茸再生中许多过程与Galectin-1的功能高度相关。与肿瘤同样高速生长且高表达Galectin-1的鹿茸组织并不发生癌变,这可能对癌症的研究有所启发。为了寻找治疗癌症的新方法,解释鹿茸再生机制,了解Galectin-1蛋白在肿瘤和鹿茸中的功能研究进展至关重要,文章就其进行了综述。

关键词: Glectin-1; 鹿茸再生; 鹿茸干细胞

Abstract: Galectin-1,a molecular that has 14 ku,is one of the lectin family members. Being used as a diagnostic index of various cancers,Galectin-1 molecule has aroused wide interest as a new target molecule for the treatment of cancer. Besides,Galectin-1 plays various normal biological functions,such as cell growth,nerve repair,revascularization and cartilage formation. To data,little research has been done about Galectin-1 in the regeneration of deer antlers,although Galectin-1 may be indispensible in the processes during antler regeneration based on its unique function. Compared to tumour,antlers also grow fast and highly express Galectin-1,but antler tissue does not become cancerous,which could inspire us for cancer research. To develop a new cancer therapy and solve the mystery of deer antler regeneration,it is important to learn about the biological functions of Galectin-1 in both tumourogenesis and antler regeneration.

Key words: Galectin-1; antler regeneration; antler stem cells

中图分类号:

秦欣欣, 孙红梅, 赵海平, 褚文辉, 王大涛, 李春义. 半乳糖凝集素1蛋白及其生物学功能[J]. , 2012, 39(6): 141-145.

QIN Xin-xin, SUN Hong-mei, ZHAO Hai-ping, CHU Wen-hui, WANG Da-tao, LI Chun-yi. Research Progress on Galectin-1 and its Biological Functions[J]. , 2012, 39(6): 141-145.

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