›› 2012, Vol. 39 ›› Issue (4): 221-223.

• 经验交流 • 上一篇    下一篇

鸡传染性法氏囊病活疫苗免疫效果评估

鲁俊鹏, 刘闯, 曾凡桂, 孔意端, 黄宁海, 徐伟, 覃健萍   

  1. 广东温氏食品集团有限公司 技术中心禽病室,广东新兴 527439
  • 收稿日期:2011-10-10 修回日期:1900-01-01 出版日期:2012-04-20 发布日期:2012-04-20
  • 通讯作者: 覃健萍

Immune Effect Assessment of Chicken IBD Live Vaccines

LU Jun-peng, LIU Chuang, ZENG Fan-gui, KONG Yi-duan, HUANG Ning-hai, XU Wei, QIN Jian-ping   

  1. Poultry Disease Laboratory of Technology Center, Guangdong Wen's Food Co. Ltd., Xinxing 527439, China
  • Received:2011-10-10 Revised:1900-01-01 Online:2012-04-20 Published:2012-04-20

摘要: 本试验选用A、B、C、D 4种商品化鸡传染性法氏囊病活疫苗免疫SPF鸡,进行攻毒试验以评估不同疫苗的免疫效果。10日龄SPF鸡分组后分别用A、B、C、D 4种商品化法氏囊病活疫苗按1羽份/只剂量接种免疫,21日龄时用1000 LD50剂量的法氏囊超强毒株(GD0104)进行攻毒,各组疫苗的保护率分别为100%、85%、100%、100%;35日龄时用1000 LD50剂量的法氏囊超强毒株(GD0104)进行攻毒,各组疫苗的保护率分别为100%、75%、95%、100%。免疫后抗体检测显示,抗体滴度水平D>A>C>B,抗体转阳速度A>D>C>B,免疫应激作用A、D>B、C。综合考虑疫苗免疫攻毒后各项指标的变化,A、D疫苗免疫效果优于其他两种活疫苗,可以有效地为SPF鸡提供保护作用。

关键词: IBD; 活疫苗; 免疫效果

Abstract: SPF chickens were inoculated with four commercial IBD live vaccines named A, B, C, D respectively, to assess the immune effect of different vaccines by challenged with IBDV. 10 days old SPF chickens were divided into different groups and were inoculated with A, B, C, D vaccines a feather copy each chicken, challenged with vvIBDV (GD0104) 1000 LD50 doses each chicken, the protection rate of each vaccine group that challenged at 21 days old were 100%, 85%, 100%, 100%; the protection rate of each vaccine group that challenged at 35 days old were 100%, 75%, 95%, 100%. Antibody tests showed that the level of antibody titers D>A>C>B; the rate of antibody turn positive: A>D>C>B; immune stress effect: A, D>B, C. Considering of the indicators change post-infection vaccination, A and D vaccines are better than the other two live vaccines, can provide effective protection for the SPF chickens.

Key words: IBD; live vaccine; immune effect

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