关键词: 水合氯醛; 速眠新Ⅱ; 二甲苯胺噻唑; 家兔; 心电图; 呼吸率; 血压

Abstract: The influence of anesthetic to the electrocardiogram,respiratory rate and blood pressure on rabbits was studied. Twenty 5 to 6 months rabbits were randomly divided into negative,Chloral Hydrate,SumianxinⅡand xylidinothiazole group,respectively. The change of arterial blood pressure,respiratory rate,the waveforms of Ⅱ leads electrocardiograph(ECG) and heart rate(HR) on rabbits were determined by RM6240BD multi-channel physiological-signal acquisition and processing system. Every wave of ECG was steady but action potential had some differences in variation time of conduction. Different anesthetics were injected and the HR influence of chloral hydrate was increased on rabbits but the influence of xylidinothiazole were decreased significant than that of SumianxinⅡ; the changes of RR among three anesthetics were higher than negative group and xylidinothiazole was the highest. All the change of systolic blood pressure(SBP) were lower than the negative group and xylidinothiazole was highest,chloral hydrate was the second,SumianxinⅡ was the third. For the diastolic blood pressure(DBP),chloral hydrate was the highest,SumianxinⅡ was the lowest,but the differential between chloral hydrate and xylidinothiazole group was not significant(P＞0.05). The change range of the electrocardiogram,heart rate,respiratory rate and blood pressure in the normal condition of rabbits had some dispute with others and it was necessary to determine it.

Key words: chloral hydrate; Sumianxi Ⅱ; xylidinothiazole; rabbit; electrocardiogram; respiration rate; blood pressure