β-神经生长因子在家兔诱导排卵中的研究进展

doi:10.16431/j.cnki.1671-7236.2022.11.019

摘要/Abstract

摘要： 家兔是刺激性排卵动物，需要性交刺激释放促性腺激素释放激素（GnRH），引发促黄体生成素（LH）增加，从而诱导成熟卵母细胞的排卵，但其排卵机制尚未完全明晰。在家兔的人工授精中，由于缺少性交的刺激，肌注或阴道内输入GnRH及其类似物被用来诱导排卵，然而这些化合物通常会对家兔繁殖产生不利影响，因此需要一种新的方法来取代激素刺激。β-神经生长因子（β-NGF）是新发现的在雌性生殖生理学中发挥作用的最有前途的物质之一，β-NGF及其受体广泛存在于家兔生殖系统中并具有重要的生理作用。同时β-NGF本身就存在于动物的精液中，且很有可能是兔的一种天然促排卵因子，使用β-NGF或许能够减少激素或其他药物的使用。作者简述了β-NGF促进家兔排卵作用及研究现状，主要从β-NGF及其受体在家兔生殖系统中的表达、β-NGF系统在诱导家兔排卵中的物种特异性，以及β-NGF诱导家兔排卵的作用机制等方面进行分析，旨在为研究家兔刺激排卵机理提供思路与理论基础，并促进β-NGF在家兔辅助生殖技术中的应用。

关键词: β-神经生长因子(β-NGF); 家兔; 排卵; 人工授精

Abstract: Rabbits are stimulated ovulating animals and require intercourse to stimulate the release of gonadotropin-releasing hormone (GnRH), which then triggers an increase in luteinizing hormone (LH), leading eventually to ovulation of mature oocytes, but the mechanism of ovulation in rabbits is not fully understood.In artificial insemination of rabbits, intramuscular or intravaginal administration of GnRH and its analogues is used to induce ovulation due to the lack of stimulation by intercourse.But these compounds usually have detrimental effects, so a new approach is needed to replace hormonal stimulation.β-nerve growth factor (β-NGF) is one of the most promising substances recently identified to play a role in female reproductive physiology.The widespread presence of β-NGF and its receptors in the reproductive system of rabbits, and has an important physiological role. At the same time, β-NGF, a protein that is itself present in the semen of animals, is likely to be a natural ovulation-promoting factor in rabbits.Therefore, the use of β-NGF may be able to reduce the use of hormones or other drugs.In this regard, in order to provide ideas and theoretical basis for studying the mechanism of ovulation stimulation in rabbits and to promote the application of β-NGF in assisted reproduction techniques in rabbits, the authors briefly describes the role of β-NGF in promoting ovulation in rabbits and the current status of research, mainly from the expression of β-NGF and its receptors in the reproductive system of rabbits, the species specificity of the β-NGF system in inducing ovulation in rabbits, and the mechanism of action of β-NGF in inducing ovulation in rabbits.

Key words: β-nerve growth factor (β-NGF); rabbit; ovulation; artificial insemination

中图分类号:

S829.1

薄欣宇, 陶晓钊, 任战军, 董响贵, 王淑辉. β-神经生长因子在家兔诱导排卵中的研究进展[J]. 中国畜牧兽医, 2022, 49(11): 4288-4295.

BO Xinyu, TAO Xiaozhao, REN Zhanjun, DONG Xianggui, WANG Shuhui. Research Progress on β-NGF in Induced Ovulation in Rabbits[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(11): 4288-4295.

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