大熊猫源肺炎克雷伯菌研究进展

doi:10.16431/j.cnki.1671-7236.2024.02.033

摘要/Abstract

摘要： 近年来,肺炎克雷伯菌在圈养大熊猫中的耐药性不断上升,甚至出现多重耐药情况,对大熊猫健康构成了严重威胁。肺炎克雷伯菌感染可能导致出血性肠炎、泌尿道感染等多种疾病。随着大熊猫数量的增加和抗菌药物的广泛应用,肺炎克雷伯菌的耐药性问题日益显著。其致病机制涉及荚膜、脂多糖、菌毛及铁载体等多个因素,共同参与了该菌的定植和侵袭过程。从传统培养到现代分子检测,针对大熊猫肺炎克雷伯菌的病原鉴定和诊断技术变得简便快速、可靠性逐渐凸显。目前,积极开展抗菌药物研发,寻找新的治疗方案,探索中药和植物提取物等替代治疗方式,抑制细菌生长并减缓耐药性发展势在必行。笔者综述了国内外关于大熊猫肺炎克雷伯菌病原生物学特性、耐药现状及诊断和防治方法的研究成果。通过对现有文献的回顾和分析,为进一步控制和延缓耐药菌株的出现,以及耐药性的传播提供了新的思路,并为大熊猫源肺炎克雷伯菌的防控提供了有益参考。

关键词: 大熊猫; 肺炎克雷伯菌; 耐药性; 耐药机制; 检测

Abstract: In recent years, the increasing drug resistance of Klebsiella pneumoniae in captive giant pandas, even the emergence of multi-drug resistance, poses a serious threat to the health of giant pandas.Infections with this bacterium may lead to various diseases such as hemorrhagic colitis and urinary tract infections.With the rise in the number of captive giant pandas and the widespread use of antimicrobial drugs, the problem of drug resistance in Klebsiella pneumoniae has become increasingly prominent.Its pathogenic mechanism involves factors such as capsules, lipopolysaccharides, pili, and iron carrier systems, all of which play a role in the colonization and invasion process of the bacterium.From traditional cultivation to modern molecular detection, techniques for pathogenic identification and diagnosis of Klebsiella pneumoniae in giant pandas have become more convenient, rapid, and reliable.However, there is an urgent need to actively engage in antimicrobial drug development, seek new treatment options, and explore alternative treatment methods such as traditional Chinese medicine and plant extracts to inhibit bacterial growth and slow down the development of drug resistance.This article reviewed the research findings on the biological characteristics of Klebsiella pneumoniae in giant pandas, its current drug resistance status, and diagnostic and therapeutic methods, both domestically and internationally.A review and analysis of existing literature provide new insights for further controlling and delaying the emergence of drug-resistant strains and the spread of drug resistance and offers a valuable reference for the prevention and control of Klebsiella pneumoniae in giant pandas.

Key words: giant panda; Klebsiella pneumoniae; drug resistance; drug resistance mechanism; detection

中图分类号:

S852.61

詹同彤, 王平峰, 郑晓美, 文琦琦, 叶刚, 邓林华, 由玉岩, 何鸣, 王茜, 李才武, 凌珊珊. 大熊猫源肺炎克雷伯菌研究进展[J]. 中国畜牧兽医, 2024, 51(2): 770-778.

ZHAN Tongtong, WANG Pingfeng, ZHENG Xiaomei, WEN Qiqi, YE Gang, DENG Linhua, YOU Yuyan, HE Ming, WANG Qian, LI Caiwu, LING Shanshan. Research Progress on Klebsiella pneumoniae from Giant Pandas[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(2): 770-778.

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