中国畜牧兽医 ›› 2022, Vol. 49 ›› Issue (12): 4756-4775.doi: 10.16431/j.cnki.1671-7236.2022.12.025
马兴树1,2
收稿日期:
2022-05-26
出版日期:
2022-12-05
发布日期:
2022-12-01
作者简介:
马兴树,E-mail:maxingshu@126.com
基金资助:
MA Xingshu1,2
Received:
2022-05-26
Online:
2022-12-05
Published:
2022-12-01
摘要: 微生物耐药是威胁人类健康、动物保健和食品安全的重大问题。为减少耐药性及动物源食品的药物残留,迫切需要探索预防和治疗疾病的替代机制,其中之一便是激活先天免疫系统对病原体攻击产生强而持久的非特异性免疫应答,这一过程称为训练免疫,即先天免疫记忆。愈来愈多的研究表明,天然免疫细胞甚至组织驻留干细胞对某些感染和疫苗接种具有保护免受再感染的免疫记忆功能,即先天免疫系统也表现出适应性免疫特征。在兽医研究领域,通过改善先天免疫系统提高家禽抗病能力的概念并不新颖,但极少有可用的、有目的的针对训练免疫的应用研究。通过训练免疫途径增强动物免疫力是一个值得关注的崭新领域,将为设计新型广谱疫苗和寻找新的药物靶点开辟新的途径。笔者综述了训练免疫领域的最新进展,阐述了家禽训练免疫调控及未来研究方向。
中图分类号:
马兴树. 家禽训练免疫研究进展[J]. 中国畜牧兽医, 2022, 49(12): 4756-4775.
MA Xingshu. Advances on Trained Immunity of Poultry[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(12): 4756-4775.
[1] WIBISONO P, WIBISONO S, WATTEYNE J, et al.Neuronal GPCR NMUR-1 regulates distinct immune responses to different pathogens[J].Cell Reports, 2022, 38(6):110321. [2] MVLLER V, DE BOER R J, BONHOEFFER S, et al.An evolutionary perspective on the systems of adaptive immunity[J].Biological Reviews, 2018, 93(1):505-528. [3] MEDZHITOV R, JANEWAY C JR.Innate immune recognition:Mechanisms and pathways[J].Immunological Reviews, 2000, 173:89-97. [4] MILLING S.Sophisticated specificity in the innate immune response[Z].Wiley Online Library, 2019. [5] NETEA M G, QUINTIN J, VAN DER MEER J W.Trained immunity:A memory for innate host defense[J].Cell Host & Microbe, 2011, 9(5):355-361. [6] BYRNE K A, LOVING C L, MCGILL J L.Innate immunomodulation in food animals:Evidence for trained immunity?[J].Frontiers in Immunology, 2020, 11:1099. [7] QUINTIN J, CHENG S C, VAN DER MEER J W, et al.Innate immune memory:Towards a better understanding of host defense mechanisms[J].Current Opinion in Immunology, 2014, 29:1-7. [8] MOURITS V P, WIJKMANS J C, JOOSTEN L A, et al.Trained immunity as a novel therapeutic strategy[J].Current Opinion in Pharmacology, 2018, 41:52-58. [9] MULDER W J, OCHANDO J, JOOSTEN L A, et al.Therapeutic targeting of trained immunity[J].Nature Reviews Drug Discovery, 2019, 18(7):553-566. [10] NETEA M G, DOMÍNGUEZ-ANDRÉS J, BARREIRO L B, et al.Defining trained immunity and its role in health and disease[J].Nature Reviews Immunology, 2020, 20(6):375-388. [11] NETEA M G, SCHLITZER A, PLACEK K, et al.Innate and adaptive immune memory:An evolutionary continuum in the host's response to pathogens[J].Cell Host & Microbe, 2019, 25(1):13-26. [12] NANKABIRWA V, TUMWINE J K, MUGABA P M, et al.Child survival and BCG vaccination:A community based prospective cohort study in Uganda[J].BMC Public Health, 2015, 15:175. [13] KLEINNIJENHUIS J, QUINTIN J, PREIJERS F, et al.Long-lasting effects of BCG vaccination on both heterologous Th1/Th17 responses and innate trained immunity[J].Journal of Innate Immunity, 2014, 6(2):152-158. [14] DOMINGUEZ-ANDRES J, NETEA M G.Long-term reprogramming of the innate immune system[J].Journal of Leukocyte Biology, 2019, 105(2):329-338. [15] NETEA M G, JOOSTEN L A, LATZ E, et al.Trained immunity:A program of innate immune memory in health and disease[J].Science, 2016, 352(6284):aaf1098. [16] KATZMARSKI N, DOMíNGUEZ-ANDRÉS J, CIROVIC B, et al.Transmission of trained immunity and heterologous resistance to infections across generations[J].Nature Immunology, 2021, 22(11):1382-1390. [17] VERWOOLDE M B, VAN BAAL J, JANSEN C A, et al.Transgenerational effects of innate immune activation in broiler breeders on growth performance and immune responsiveness[J].Poultry Science, 2021, 100(11):101413. [18] VERWOOLDE M B, ARTS J, JANSEN C A, et al.Transgenerational effects of maternal immune activation on specific antibody responses in layer chickens[J].Frontiers in Veterinary Science, 2022, 9:832130. [19] HALDANE J B S.Disease and Evolution[M].Malaria:Genetic and Evolutionary Aspects.Springer, 2006. [20] HOWARD J C, JACK R S.Evolution of immunity and pathogens[J].European Journal of Immunology 2007, 37(7):1721-1723. [21] AKIRA S, UEMATSU S, TAKEUCHI O.Pathogen recognition and innate immunity[J].Cell, 2006, 124(4):783-801. [22] HIRANO M, DAS S, GUO P, et al.The evolution of adaptive immunity in vertebrates[J].Advances in Immunology, 2011, 109:125-157. [23] COOPER M D, ALDER M N.The evolution of adaptive immune systems[J].Cell, 2006, 124(4):815-822. [24] KISHISHITA N, NAGAWA F.Evolution of adaptive immunity:Implications of a third lymphocyte lineage in lampreys[J].Bioessays, 2014, 36(3):244-250. [25] GOURBAL B, PINAUD S, BECKERS G J, et al.Innate immune memory:An evolutionary perspective[J].Immunological Reviews, 2018, 283(1):21-40. [26] PURVIS A, HECTOR A.Getting the measure of biodiversity[J].Nature, 2000, 405(6783):212-219. [27] HIRANO M.Evolution of vertebrate adaptive immunity:Immune cells and tissues, and AID/APOBEC cytidine deaminases[J].Bioessays, 2015, 37(8):877-887. [28] LITMAN G W, COOPER M D.Why study the evolution of immunity?[J].Nature Immunology, 2007, 8(6):547-548. [29] QUINTIN J, SAEED S, MARTENS J H, et al.Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes[J].Cell Host & Microbe, 2012, 12(2):223-232. [30] KLEINNIJENHUIS J, QUINTIN J, PREIJERS F, et al.Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes[J].Proceedings of the National Academy of Sciences of the United States of America, 2012, 109(43):17537-17542. [31] ARTS R J, MOORLAG S J, NOVAKOVIC B, et al.BCG vaccination protects against experimental viral infection in humans through the induction of cytokines associated with trained immunity[J].Cell Host & Microbe, 2018, 23(1):89-100. [32] BUFFEN K, OOSTING M, QUINTIN J, et al.Autophagy controls BCG-induced trained immunity and the response to intravesical BCG therapy for bladder cancer[J].PLoS Pathogens, 2014, 10(10):e1004485. [33] MITROULIS I, RUPPOVA K, WANG B, et al.Modulation of myelopoiesis progenitors is an integral component of trained immunity[J].Cell, 2018, 172(1-2):147-161. [34] BAI W, LIU H, JI Q, et al.TLR3 regulates mycobacterial RNA-induced IL-10 production through the PI3K/Akt signaling pathway[J].Cellular Signalling, 2014, 26(5):942-950. [35] SPETH M T, REPNIK U, MVLLER E, et al.Poly(I:C)-encapsulating nanoparticles enhance innate immune responses to the tuberculosis vaccine Bacille Calmette-Guérin (BCG) via synergistic activation of innate immune receptors[J].Molecular Pharmaceutics, 2017, 14(11):4098-4112. [36] NOVAKOVIC B, HABIBI E, WANG S Y, et al.β-glucan reverses the epigenetic state of LPS-induced immunological tolerance[J].Cell, 2016, 167(5):1354-1368. [37] FANUCCHI S, FOK E T, DALLA E, et al.Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments[J].Nature Genetics, 2019, 51(1):138-150. [38] ARTS R J, NOVAKOVIC B, TER HORST R, et al.Glutaminolysis and fumarate accumulation integrate immunometabolic and epigenetic programs in trained immunity[J].Cell Metabolism, 2016, 24(6):807-819. [39] CHENG S C, QUINTIN J, CRAMER R A, et al.mTOR-and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity[J].Science, 2014, 345(6204):1250684. [40] ARTS R J, CARVALHO A, LA ROCCA C, et al.Immunometabolic pathways in BCG-induced trained immunity[J].Cell Reports, 2016, 17(10):2562-2571. [41] KEATING S T, EL-OSTA A.Epigenetics and metabolism[J].Circulation Research, 2015, 116(4):715-736. [42] SOHRABI Y, DOS SANTOS J C, DORENKAMP M, et al.Trained immunity as a novel approach against COVID-19 with a focus on Bacillus Calmette-Guérin vaccine:Mechanisms, challenges and perspectives[J].Clinical & Translational Immunology, 2020, 9(12):e1228. [43] KAUFMANN E, SANZ J, DUNN J L, et al.BCG educates hematopoietic stem cells to generate protective innate immunity against tuberculosis[J].Cell, 2018, 172(1-2):176-190. [44] SCANES C G, DRIDI S.Sturkie's avian Physiology[M].Salt Lake City:American Academic Press, 2021. [45] KAISER P.Advances in avian immunology-Prospects for disease control:A review[J].Avian Pathology, 2010, 39(5):309-324. [46] LEE K A.Linking immune defenses and life history at the levels of the individual and the species[J].Integrative and Comparative Biology, 2006, 46(6):1000-1015. [47] KLASING K.Nutrition and the immune system[J].British Poultry Science, 2007, 48(5):525-537. [48] VAN DER MEER J W, JOOSTEN L A, RIKSEN N, et al.Trained immunity:A smart way to enhance innate immune defence[J].Molecular Immunology, 2015, 68(1):40-44. [49] COX C, STUARD L, KIM S, et al.Performance and immune responses to dietary β-glucan in broiler chicks[J].Poultry Science, 2010, 89(9):1924-1933. [50] TANG X, GAO J, YUAN F, et al.Effects of Sophy β-glucan on growth performance, carcass traits, meat composition, and immunological responses of Peking ducks[J].Poultry Science, 2011, 90(4):737-745. [51] HUFF G, HUFF W, JALUKAR S, et al.The effects of yeast feed supplementation on turkey performance and pathogen colonization in a transport stress/Escherichia coli challenge[J].Poultry Science, 2013, 92(3):655-662. [52] JACOB J P, PESCATORE A J.Barley β-glucan in poultry diets[J].Annals of Translational Medicine, 2014, 2(2):20. [53] GUO Y, ALI R, QURESHI M.The influence of β-glucan on immune responses in broiler chicks[J].Immunopharmacology and Immunotoxicology, 2003, 25(3):461-472. [54] HUFF G, HUFF W, FARNELL M, et al.Bacterial clearance, heterophil function, and hematological parameters of transport-stressed turkey poults supplemented with dietary yeast extract[J].Poultry Science, 2010, 89(3):447-456. [55] LOWRY V, FARNELL M, FERRO P, et al.Purified β-glucan as an abiotic feed additive up-regulates the innate immune response in immature chickens against Salmonella enterica serovar Enteritidis[J].International Journal of Food Microbiology, 2005, 98(3):309-318. [56] HUFF G, HUFF W, RATH N, et al.Limited treatment with β-1, 3/1, 6-glucan improves production values of broiler chickens challenged with Escherichia coli[J].Poultry Science, 2006, 85(4):613-618. [57] TENG P Y, KIM W K.Review:Roles of prebiotics in intestinal ecosystem of broilers[J].Frontiers in Veterinary Science, 2018:5, 245. [58] VERWOOLDE M B, VAN DEN BIGGELAAR R H, VAN BAAL J, et al.Training of primary chicken monocytes results in enhanced pro-inflammatory responses[J].Veterinary Sciences, 2020, 7(3):115. [59] VERWOOLDE M B, VAN DEN BIGGELAAR R H, DE VRIES REILINGH G, et al.Innate immune training and metabolic reprogramming in primary monocytes of broiler and laying hens[J].Developmental & Comparative Immunology, 2021, 114:103811. [60] KLINMAN D M.Immunotherapeutic uses of CpG oligodeoxynucleotides[J].Nature Reviews Immunology, 2004, 4(4):249-259. [61] ALLAN B, WHELER C, KÖSTER W, et al.In ovo administration of innate immune stimulants and protection from early chick mortalities due to yolk sac infection[J].Avian Diseases, 2018, 62(3):316-321. [62] ABDUL-CADER M S, AMARASINGHE A, PALOMINO-TAPIA V, et al.In ovo CpG DNA delivery increases innate and adaptive immune cells in respiratory, gastrointestinal and immune systems post-hatch correlating with lower Infectious laryngotracheitis virus infection[J].PLoS One, 2018, 13(3):e0193964. [63] ILG T.The immunostimulator Victrio activates chicken Toll-like receptor 21[J].Veterinary Immunology and Immunopathology, 2020, 220:109977. [64] PEEBLES E.In ovo applications in poultry:A review[J].Poultry Science, 2018, 97(7):2322-2338. [65] BERGHOF T, PARMENTIER H, LAMMERS A.Transgenerational epigenetic effects on innate immunity in broilers:An underestimated field to be explored?[J].Poultry Science, 2013, 92(11):2904-2913. [66] BEUTLER B, JIANG Z, GEORGEL P, et al.Genetic analysis of host resistance:Toll-like receptor signaling and immunity at large[J].Annual Review of Immunology, 2006, 24:353-389. [67] OKAMURA M, MATSUMOTO W, SEIKE F, et al.Efficacy of soluble recombinant FliC protein from Salmonella enterica serovar Enteritidis as a potential vaccine candidate against homologous challenge in chickens[J].Avian Diseases, 2012, 56(2):354-358. [68] KHALIFEH M, AMAWI M, ABU-BASHA E, et al.Assessment of humoral and cellular-mediated immune response in chickens treated with tilmicosin, florfenicol, or enrofloxacin at the time of Newcastle disease vaccination[J].Poultry Science, 2009, 88(10):2118-2124. [69] GUPTA S K, DEB R, GAIKWAD S, et al.Recombinant flagellin and its cross-talk with lipopolysaccharide-Effect on pooled chicken peripheral blood mononuclear cells[J].Research in Veterinary Science, 2013, 95(3):930-935. [70] OWEN A M, FULTS J B, PATIL N K, et al.TLR agonists as mediators of trained immunity:Mechanistic insight and immunotherapeutic potential to combat infection[J].Frontiers in Immunology, 2021, 11:622614. [71] HERNANDEZ A, PATIL N K, STOTHERS C L, et al.Immunobiology and application of Toll-like receptor 4 agonists to augment host resistance to infection[J].Pharmacological Research, 2019, 150:104502. [72] ABDUL-CADER M S, DE SILVA SENAPATHI U, AHMED-HASSAN H, et al.Single stranded (ss) RNA-mediated antiviral response against Infectious laryngotracheitis virus infection[J].BMC Microbiology, 2019, 19(1):34. [73] MIFSUD E J, TAN A C, JACKSON D C.TLR agonists as modulators of the innate immune response and their potential as agents against infectious disease[J].Frontiers in Immunology, 2014, 5:79. [74] ST PAUL M, BRISBIN J T, BARJESTEH N, et al.Avian influenza virus vaccines containing Toll-like receptors 2 and 5 ligand adjuvants promote protective immune responses in chickens[J].Viral Immunology, 2014, 27(4):160-166. [75] PLOEGAERT T, REILINGH G D V, NIEUWLAND M, et al.Intratracheally administered pathogen-associated molecular patterns affect antibody responses of poultry[J].Poultry Science, 2007, 86(8):1667-1676. [76] PAUL M S, MALLICK A I, READ L R, et al.Prophylactic treatment with Toll-like receptor ligands enhances host immunity to Avian influenza virus in chickens[J].Vaccine, 2012, 30(30):4524-4531. [77] TSENG L P, CHIOU C J, CHEN C C, et al.Effect of lipopolysaccharide on intranasal administration of liposomal Newcastle disease virus vaccine to SPF chickens[J].Veterinary Immunology and Immunopathology, 2009, 131(3-4):285-289. [78] HADDADI S, KIM D S, JASMINE H, et al.Induction of Toll-like receptor 4 signaling in avian macrophages inhibits Infectious laryngotracheitis virus replication in a nitric oxide dependent way[J].Veterinary Immunology and Immunopathology, 2013, 155(4):270-275. [79] PARVIZI P, ABDUL-CAREEM M F, MALLICK A I, et al.The effects of administration of ligands for Toll-like receptor 4 and 21 against Marek's disease in chickens[J].Vaccine, 2014, 32(17):1932-1938. [80] CHAUNG H C, CHENG L T, HUNG L H, et al.Salmonella flagellin enhances mucosal immunity of avian influenza vaccine in chickens[J].Veterinary Microbiology, 2012, 157(1-2):69-77. [81] SONG L, ZHANG Y, YUN N E, et al.Superior efficacy of a recombinant flagellin:H5N1 HA globular head vaccine is determined by the placement of the globular head within flagellin[J].Vaccine, 2009, 27(42):5875-5884. [82] LIU G, SONG L, REISEROVA L, et al.Flagellin-HA vaccines protect ferrets and mice against H5N1 Highly pathogenic avian influenza virus (HPAIV) infections[J].Vaccine, 2012, 30(48):6833-6838. [83] GENOVESE K J, HE H, LOWRY V K, et al.Dynamics of the avian inflammatory response to Salmonella following administration of the Toll-like receptor 5 agonist flagellin[J].FEMS Immunology & Medical Microbiology, 2007, 51(1):112-117. [84] HUANG J L, YIN Y X, PAN Z M, et al.Intranasal immunization with chitosan/pCAGGS-flaA nanoparticles inhibits Campylobacter jejuni in a White Leghorn model[J].Journal of Biomedicine and Biotechnology, 2010, 2010:589476. [85] WIDDERS P, THOMAS L, LONG K, et al.The specificity of antibody in chickens immunised to reduce intestinal colonisation with Campylobacter jejuni[J].Veterinary Microbiology, 1998, 64(1):39-50. [86] YIN G, QIN M, LIU X, et al.An Eimeria vaccine candidate based on Eimeria tenella immune mapped protein 1 and the TLR-5 agonist Salmonella Typhimurium FliC flagellin[J].Biochemical and Biophysical Research Communications, 2013, 440(3):437-442. [87] MARCUS P I, SEKELLICK M J.Combined sequential treatment with interferon and dsRNA abrogates virus resistance to interferon action[J].Journal of Interferon & Cytokine Research, 2001, 21(6):423-429. [88] PARVIZI P, MALLICK A I, HAQ K, et al.A Toll-like receptor 3 ligand enhances protective effects of vaccination against Marek's disease virus and hinders tumor development in chickens[J].Viral Immunology, 2012, 25(5):394-401. [89] STEWART C R, BAGNAUD-BAULE A, KARPALA A J, et al.Toll-like receptor 7 ligands inhibit influenza A infection in chickens[J].Journal of Interferon & Cytokine Research, 2012, 32(1):46-51. [90] SWAGGERTY C, HE H, GENOVESE K, et al.Loxoribine pretreatment reduces Salmonella Enteritidis organ invasion in 1-day-old chickens[J].Poultry Science, 2012, 91(4):1038-1042. [91] MALLICK A I, PARVIZI P, READ L R, et al.Enhancement of immunogenicity of a virosome-based avian influenza vaccine in chickens by incorporating CpG-ODN[J].Vaccine, 2011, 29(8):1657-1665. [92] ST PAUL M, BARJESTEH N, BRISBIN J T, et al.Effects of ligands for Toll-like receptors 3, 4, and 21 as adjuvants on the immunogenicity of an avian influenza vaccine in chickens[J].Viral Immunology, 2014, 27(4):167-173. [93] HUNG L H, TSAI P C, WANG C H, et al.Immunoadjuvant efficacy of plasmids with multiple copies of a CpG motif coadministrated with avian influenza vaccine in chickens[J].Vaccine, 2011, 29(29-30):4668-4675. [94] ZHANG L H, TIAN X S, ZHOU F Z.Vaccination with Newcastle disease vaccine and CpG oligodeoxynucleotides induces specific immunity and protection against Newcastle disease virus in SPF chicken[J].Veterinary Immunology and Immunopathology, 2007, 115(3-4):216-222. [95] ZHANG L, ZHANG M, LI J, et al.Enhancement of mucosal immune responses by intranasal co-delivery of Newcastle disease vaccine plus CpG oligonucleotide in SPF chickens in vivo[J].Research in Veterinary Science, 2008, 85(3):495-502. [96] MAHMOOD M, SIDDIQUE M, HUSSAIN I, et al.Protection capability of recombinant plasmid DNA vaccine containing VP2 gene of very virulent Infectious bursal disease virus in chickens adjuvanted with CpG oligodeoxynucleotide[J].Vaccine, 2006, 24(22):4838-4846. [97] WANG X, JIANG P, DEEN S, et al.Efficacy of DNA vaccines against Infectious bursal disease virus in chickens enhanced by coadministration with CpG oligodeoxynucleotide[J].Avian Diseases, 2003, 47(4):1305-1312. [98] DAR A, POTTER A, TIKOO S, et al.CpG oligodeoxynucleotides activate innate immune response that suppresses Infectious bronchitis virus replication in chicken embryos[J].Avian Diseases, 2009, 53(2):261-267. [99] ZHANG D, LI H, ZHANG Z, et al.Antibody responses induced by recombinant ALV-A gp85 protein vaccine combining with CpG-ODN adjuvant in breeder hens and the protection for their offspring against early infection[J].Antiviral Research, 2015, 116:20-26. [100] SHAHROKHI V, RAD M, KALIDARI G A.Treatment of newly hatched chicken with CpG oligodeoxynucleotides decreases liver/spleen colonization of Salmonella enteritidis in broiler chickens[J].Comparative Clinical Pathology, 2013, 22(5):935-939. [101] HE H, LOWRY V K, SWAGGERTY C L, et al.In vitro activation of chicken leukocytes and in vivo protection against Salmonella Enteritidis organ invasion and peritoneal S.Enteritidis infection-induced mortality in neonatal chickens by immunostimulatory CpG oligodeoxynucleotide[J].FEMS Immunology & Medical Microbiology, 2005, 43(1):81-99. [102] TAGHAVI A, ALLAN B, MUTWIRI G, et al.Protection of neonatal broiler chicks against Salmonella Typhimurium septicemia by DNA containing CpG motifs[J].Avian Diseases, 2008, 52(3):398-406. [103] GOMIS S, BABIUK L, GODSON D L, et al.Protection of chickens against Escherichia coli infections by DNA containing CpG motifs[J].Infection and Immunity, 2003, 71(2):857-863. [104] GOMIS S, BABIUK L, ALLAN B, et al.Protection of neonatal chicks against a lethal challenge of Escherichia coli using DNA containing cytosine-phosphodiester-guanine motifs[J].Avian Diseases, 2004, 48(4):813-822. [105] GOMIS S, BABIUK L, ALLAN B, et al.Protection of chickens against a lethal challenge of Escherichia coli by a vaccine containing CpG oligodeoxynucleotides as an adjuvant[J].Avian Diseases, 2007, 51(1):78-83. [106] TAGHAVI A, ALLAN B, MUTWIRI G, et al.Enhancement of immunoprotective effect of CpG-ODN by formulation with polyphosphazenes against E.coli septicemia in neonatal chickens[J].Current Drug Delivery, 2009, 6(1):76-82. [107] DALLOUL R A, LILLEHOJ H S, KLINMAN D M, et al.In ovo administration of CpG oligodeoxynucleotides and the recombinant microneme protein MIC2 protects against Eimeria infections[J].Vaccine, 2005, 23(24):3108-3113. [108] DALLOUL R A, LILLEHOJ H S, OKAMURA M, et al.In vivo effects of CpG oligodeoxynucleotide on Eimeria infection in chickens[J].Avian Diseases, 2004, 48(4):783-790. [109] WINDISCH W, SCHEDLE K, PLITZNER C, et al.Use of phytogenic products as feed additives for swine and poultry[J].Journal of Animal Science, 2008, 86(suppl_14):E140-E148. [110] KIM D, LILLEHOJ H, LEE S, et al.High-throughput gene expression analysis of intestinal intraepithelial lymphocytes after oral feeding of carvacrol, cinnamaldehyde, or Capsicum oleoresin[J].Poultry Science, 2010, 89(1):68-81. [111] LEE S, LILLEHOJ H, HONG Y, et al. In vitro effects of plant and mushroom extracts on immunological function of chicken lymphocytes and macrophages[J].British Poultry Science, 2010, 51(2):213-221. [112] PARK I J, CHA S Y, KANG M, et al.Effect of proanthocyanidin-rich extract from Pinus radiata bark on immune response of specific-pathogen-free White Leghorn chickens[J].Poultry Science, 2011, 90(5):977-982. [113] POURHOSSEIN Z, QOTBI A A A, SEIDAVI A, et al.Effect of different levels of dietary sweet orange (Citrus sinensis) peel extract on humoral immune system responses in broiler chickens[J].Animal Science Journal, 2015, 86(1):105-110. [114] LEE S H, LILLEHOJ H S, CHUN H K, et al. In vitro treatment of chicken peripheral blood lymphocytes, macrophages, and tumor cells with extracts of Korean medicinal plants[J].Nutrition Research, 2007, 27(6):362-366. [115] LEE K, LEE S, LILLEHOJ H, et al.Effects of direct-fed microbials on growth performance, gut morphometry, and immune characteristics in broiler chickens[J].Poultry Science, 2010, 89:203-216. [116] ISLAM M R, OOMAH D B, DIARRA M S.Potential immunomodulatory effects of non-dialyzable materials of cranberry extract in poultry production[J].Poultry Science, 2017, 96(2):341-350. [117] LEE S H, LILLEHOJ H S, JANG S I, et al.Cinnamaldehyde enhances in vitro parameters of immunity and reduces in vivo infection against avian coccidiosis[J].British Journal of Nutrition, 2011, 106(6):862-869. [118] MACPHERSON A J, HARRIS N L.Interactions between commensal intestinal bacteria and the immune system[J].Nature Reviews Immunology, 2004, 4(6):478-485. [119] MAISONNIER S, GOMEZ J, BREE A, et al.Effects of microflora status, dietary bile salts and guar gum on lipid digestibility, intestinal bile salts, and histomorphology in broiler chickens[J].Poultry Science, 2003, 82(5):805-814. [120] BAR-SHIRA E, SKLAN D, FRIEDMAN A.Establishment of immune competence in the avian GALT during the immediate post-hatch period[J].Developmental & Comparative Immunology, 2003, 27(2):147-157. [121] COSTELLO E K, LAUBER C L, HAMADY M, et al.Bacterial community variation in human body habitats across space and time[J].Science, 2009, 326(5960):1694-1697. [122] CERF-BENSUSSAN N, GABORIAU-ROUTHIAU V.The immune system and the gut microbiota:Friends or foes?[J].Nature Reviews Immunology, 2010, 10(10):735-744. [123] THAISS C A, ZMORA N, LEVY M, et al.The microbiome and innate immunity[J].Nature, 2016, 535(7610):65-74. [124] STANLEY D, DENMAN S E, HUGHES R J, et al.Intestinal microbiota associated with differential feed conversion efficiency in chickens[J].Applied Microbiology and Biotechnology, 2012, 96(5):1361-1369. [125] BARNES E M.The intestinal microflora of poultry and game birds during life and after storage.Address of the president of the society for applied bacteriology delivered at a meeting of the society on 10 January 1979[J].The Journal of Applied Bacteriology, 1979, 46(3):407-419. [126] VAN DER WIELEN P W, BIESTERVELD S, NOTERMANS S, et al.Role of volatile fatty acids in development of the cecal microflora in broiler chickens during growth[J].Applied and Environmental Microbiology, 2000, 66(6):2536-2540. [127] GABRIEL I, LESSIRE M, MALLET S, et al.Microflora of the digestive tract:Critical factors and consequences for poultry[J].World's Poultry Science Journal, 2006, 62(3):499-511. [128] FARNELL M, DONOGHUE A, DE LOS SANTOS F S, et al.Upregulation of oxidative burst and degranulation in chicken heterophils stimulated with probiotic bacteria[J].Poultry Science, 2006, 85(11):1900-1906. [129] NEGI S, DAS D K, PAHARI S, et al.Potential role of gut microbiota in induction and regulation of innate immune memory[J].Frontiers in Immunology, 2019, 10:2441. [130] SÁNCHEZ-RAMÓN S, CONEJERO L, NETEA M G, et al.Trained immunity-based vaccines:A new paradigm for the development of broad-spectrum anti-infectious formulations[J].Frontiers in Immunology, 2018, 9:2936. [131] GOODRIDGE H S, AHMED S S, CURTIS N, et al.Harnessing the beneficial heterologous effects of vaccination[J].Nature Reviews Immunology, 2016, 16(6):392-400. [132] SUPER M, DOHERTY E J, CARTWRIGHT M J, et al.Biomaterial vaccines capturing pathogen-associated molecular patterns protect against bacterial infections and septic shock[J].Nature Biomedical Engineering, 2022, 6(1):8-18. [133] JANEWAY JR C A, MEDZHITOV R.Innate immune recognition[J].Annual Review of Immunology, 2002, 20(1):197-216. [134] KIM J, LI W A, CHOI Y, et al.Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy[J].Nature Biotechnology, 2015, 33(1):64-72. [135] BISTONI F, VECCHIARELLI A, CENCI E, et al.Evidence for macrophage-mediated protection against lethal Candida albicans infection[J].Infection and Immunity, 1986, 51(2):668-674. [136] PASQUALI C, SALAMI O, TANEJA M, et al.Enhanced mucosal antibody production and protection against respiratory infections following an orally administered bacterial extract[J].Frontiers in Medicine, 2014, 1:41. [137] ROTH M, PASQUALI C, STOLZ D, et al.Broncho Vaxom (OM-85) modulates rhinovirus docking proteins on human airway epithelial cells via Erk1/2 mitogen activated protein kinase and cAMP[J].PLoS One, 2017, 12(11):e0188010. [138] BESSLER W G, VOR DEM ESCHE U, MASIHI N.The bacterial extract OM-85 BV protects mice against influenza and Salmonella infection[J].International Immunopharmacology, 2010, 10(9):1086-1090. [139] SCHEID A, BORRIELLO F, PIETRASANTA C, et al.Adjuvant effect of Bacille Calmette-Guérin on hepatitis B vaccine immunogenicity in the preterm and term newborn[J].Frontiers in Immunology, 2018, 9:29. [140] FOSTER S L, HARGREAVES D C, MEDZHITOV R.Gene-specific control of inflammation by TLR-induced chromatin modifications[J].Nature, 2007, 447(7147):972-978. [141] BARTON E S, WHITE D W, CATHELYN J S, et al.Herpesvirus latency confers symbiotic protection from bacterial infection[J].Nature, 2007, 447(7142):326-329. [142] CHEN F, WU W, MILLMAN A, et al.Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion[J].Nature Immunology, 2014, 15(10):938-946. [143] SUN J C, BEILKE J N, LANIER L L.Adaptive immune features of natural killer cells[J].Nature, 2009, 457(7229):557-561. [144] KLEINNIJENHUIS J, QUINTIN J, PREIJERS F, et al.BCG-induced trained immunity in NK cells:Role for non-specific protection to infection[J].Clinical Immunology, 2014, 155(2):213-219. [145] GIRARDIN S E, BONECA I G, VIALA J, et al.Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection[J].Journal of Biological Chemistry, 2003, 278(11):8869-8872. [146] SHEEDY F J, GREBE A, RAYNER K J, et al.CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation[J].Nature Immunology, 2013, 14(8):812-820. [147] BEKKERING S, QUINTIN J, JOOSTEN L A, et al.Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes[J].Arteriosclerosis, Thrombosis, and Vascular Biology, 2014, 34(8):1731-1738. [148] KRAWCZYK C M, HOLOWKA T, SUN J, et al.Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation[J].Blood, 2010, 115(23):4742-4749. [149] BEKKERING S, ARTS R J, NOVAKOVIC B, et al.Metabolic induction of trained immunity through the mevalonate pathway[J].Cell, 2018, 172(1-2):135-146. [150] CAREY B W, FINLEY L W, CROSS J R, et al.Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells[J].Nature, 2015, 518(7539):413-416. |
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