[1] WANG X,FANG L,LIU S,et al.Susceptibility of porcine IPI-2I intestinal epithelial cells to infection with Swine enteric coronaviruses[J].Veterinary Microbiology,2019,233:21-27. [2] WOO P C Y,LAU S K P,LAM C S F,et al.Discovery of seven novel mammalian and Avian coronaviruses in the genus Deltacoronavirus supports bat coronaviruses as the gene source of Alphacoronavirus and Betacoronavirus and Avian coronaviruses as the gene source of Gammacoronavirus and Deltacoronavirus[J].Journal of Virology,2012,86(7):3995-4008. [3] MORA-DÍAZ J C,PIÑEYRO P E,HOUSTON E,et al.Porcine hemagglutinating encephalomyelitis virus:A review[J].Frontiers in Veterinary Science,2019,6:53-64. [4] 张帆帆,唐玉新,宋德平,等.新现猪Delta冠状病毒RT-PCR检测方法的建立及其应用[J].中国农业科学,2016,49(7):1408-1416. ZHANG F F,TANG Y X,SONG D P,et al.Establishment and application of a RT-PCR assay for detection of newly emerged Porcine deltacoronavirus[J].Scientia Agricultura Sinica,2016,49(7):1408-1416.(in Chinese) [5] 李仕林,王雅雯,姜水兵,等.致猪腹泻的冠状病毒病的研究进展[J].现代畜牧兽医,2021,2:89-92. LI S L,WANG Y W,JIANG S B,et al.Advances in the study of porcine diarrheal coronavirus disease[J].Modern Journal of Animal Husbandry and Veterinary Medicine,2021,2:89-92.(in Chinese) [6] WANG Q,VLASOVA A N,KENNEY S P,et al.Emerging and re-emerging coronaviruses in pigs[J].Current Opinion in Virology,2019,34:39-49. [7] LUAN Y,XU W.The structure and main functions of aminopeptidase N[J].Current Medicinal Chemistry,2007,14(6):639-647. [8] DELMAS B,GELFI J,KUT E,et al.Determinants essential for the Transmissible gastroenteritis virus-receptor interaction reside within a domain of aminopeptidase-N that is distinct from the enzymatic site[J].Journal of Virology,1994,68(8):5216-5224. [9] CONG Y,LI X,BAI Y,et al.Porcine aminopeptidase N mediated polarized infection by Porcine epidemic diarrhea virus in target cells[J].Virology,2015,478:1-8. [10] KOCHAN G,KROJER T,HARVEY D,et al.Crystal structures of the endoplasmic reticulum aminopeptidase-1(ERAP1) reveal the molecular basis for N-terminal peptide trimming[J].Proceedings of the National Academy of Sciences of the United States of America,2011,108(19):7745-7750. [11] MINA-OSORIO P.The moonlighting enzyme CD13:Old and new functions to target[J].Trends in Molecular Medicine,2008,14(8):361-371. [12] WICKSTRÖM M,LARSSON R,NYGREN P,et al.Aminopeptidase N (CD13) as a target for cancer chemotherapy[J].Cancer Science,2011,102(3):501-508. [13] DELMAS B,GELFI J,L'HARIDON R,et al.Aminopeptidase N is a major receptor for the entero-pathogenic coronavirus TGEV[J].Nature,1992,357(6377):417-420. [14] YEAGER C L,ASHMUN R A,WILLIAMS R K,et al.Human aminopeptidase N is a receptor for human coronavirus 229E[J].Nature,1992,357(6377):420-422. [15] TRESNAN D B,HOLMES K V.Feline aminopeptidase N is a receptor for all group Ⅰ coronaviruses[J].Advances in Experimental Medicine and Biology,1998,440:69-75. [16] 邓凤.猪流行性腹泻病毒S蛋白受体识别特性与NSP9蛋白结构研究[D].武汉:华中农业大学,2016. DENG F.The researches on receptor binding characteristics of the S protein and structure of the NSP9 protein of Porcine epidemic diarrhea virus[D].Wuhan:Huazhong Agricultural University,2016.(in Chinese) [17] KHATRI M.Porcine epidemic diarrhea virus replication in duck intestinal cell line[J].Emerging Infectious Diseases,2015,21(3):549-550. [18] BAI D,FANG L,XIA S,et al.Porcine deltacoronavirus (PDCoV) modulates calcium influx to favor viral replication[J].Virology,2020,539:38-48. [19] ZHU X,LIU S,WANG X,et al.Contribution of porcine aminopeptidase N to Porcine deltacoronavirus infection[J].Emerging Microbes and Infections,2018,7(1):65-77. [20] 王晓朋,徐奎,魏迎辉,等.CRISPR/Cas9介导的猪IPEC-J2细胞CD13基因敲除细胞系的建立[J].畜牧兽医学报,2019,50(7):1319-1327. WANG X P,XU K,WEI Y H,et al.Establishment of CD13 gene knock out IPEC-J2 cell lines mediated by CRISPR/Cas9 system[J].Acta Veterinaria et Zootechnica Sinica,2019,50(7):1319-1327.(in Chinese) [21] 罗磊.APN基因编辑猪生产及其对TGEV和PEDV抗性的研究[D].合肥:安徽农业大学,2019. LUO L.Production of APN gene-edited pig and their resistance to TGEV and PEDV[D].Hefei:Anhui Agricultural University,2019.(in Chinese) [22] MARRAFFINI L A,SONTHEIMER E J.Self versus non-self discrimination during CRISPR RNA-directed immunity[J].Nature,2010,463(7280):568-571. [23] JINEK M,CHYLINSKI K,FONFARA I,et al.A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity[J].Science,2012,337(6096):816-821. [24] CONG L,RAN F A,COX D,et al.Multiplex genome engineering using CRISPR/Cas9 systems[J].Science,2013,339(6121):819-823. [25] QI L S,LARSON M H,GILBERT L A,et al.Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression[J].Cell,2013,152(5):1173-1183. [26] WANG K,OUYANG H,XIE Z,et al.Efficient generation of myostatin mutations in pigs using the CRISPR/Cas9 system[J].Scientific Reports,2015,5(1):16623-16633. [27] WHITWORTH K M,ROWLAND R R R,EWEN C L,et al.Gene-edited pigs are protected from Porcine reproductive and respiratory syndrome virus[J].Nature Biotechnology,2015,34(1):20-22. [28] YANG H,ZHANG J,ZHANG X,et al.CD163 knockout pigs are fully resistant to highly pathogenic Porcine reproductive and respiratory syndrome virus[J].Antiviral Research,2018,151:63-70. [29] XU K,ZHOU Y,MU Y,et al.CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance[J].Elife,2020,9:e57132. [30] CHEN L,LIN Y L,PENG G,et al.Structural basis for multifunctional roles of mammalian aminopep-tidase N[J].Proceedings of the National Academy of Sciences of the United States of America,2012,109(44):17966-17971. [31] 刘博奇,李广兴,王衡,等.猪传染性胃肠炎病毒特异性受体APN功能区的初步鉴定[J].黑龙江畜牧兽医,2009,11:21-23. LIU B Q,LI G X,WANG H,et al.Initial identification of the domain of TGEV specific receptor APN[J].Heilongjiang Animal Science and Veterinary Medicine,2009,11:21-23.(in Chinese) [32] LI W,LUO R,HE Q,et al.Aminopeptidase N is not required for Porcine epidemic diarrhea virus cell entry[J].Virus Research,2017,235:6-13. [33] PARK J E,PARK E S,YU J E,et al.Development of transgenic mouse model expressing porcine aminopeptidase N and its susceptibility to Porcine epidemic diarrhea virus[J].Virus Research,2015,197:108-115. [34] WHITWORTH K M,ROWLAND R R R,PETROVAN V,et al.Resistance to coronavirus infection in amino peptidase N-deficient pigs[J].Transgenic Research,2019,28(1):21-32. [35] LUO L,WANG S,ZHU L,et al.Aminopeptidase N-null neonatal piglets are protected from Transmissible gastroenteritis virus but not Porcine epidemic diarrhea virus[J].Scientific Reports,2019,9(1):1-10. [36] WANG B,LIU Y,JI C,et al.Porcine deltacoronavirus engages the Transmissible gastroenteritis virus functional receptor porcine aminopeptidase N for infectious cellular entry[J].Journal of Virology,2018,92(12):e00318-18. [37] KIM L,HAYES J,LEWIS P,et al.Molecular characterization and pathogenesis of Transmissible gastroenteritis coronavirus (TGEV) and Porcine respiratory coronavirus (PRCV) field isolates co-circulating in a swine herd[J].Archives of Virology,2000,145(6):1133-1147. [38] WESLEY R D,WOODS R D,CHEUNG A K.Genetic analysis of Porcine respiratory coronavirus,an attenuated variant of Transmissible gastroenteritis virus[J].Journal of Virology,1991,65(6):3369-3373. [39] DELMAS B,GELFI J,SJÖSTRÖM H,et al.Further characterization of aminopeptidase-N as a receptor for coronaviruses[J].Advances in Experimental Medicine and Biology,1993,342:293-298. [40] EDWARDS C E,YOUNT B L,GRAHAM R L,et al.Swine acute diarrhea syndrome coronavirus replication in primary human cells reveals potential susceptibility to infection[J].Proceedings of the National Academy of Sciences of the United States of America,2020,117(43):26915-26925. [41] BONAFONT J,MENCÍA Á,GARCÍA M,et al.Clinically relevant correction of recessive dystrophic epidermolysis bullosa by dual sgRNA CRISPR/Cas9-mediated gene editing[J].Molecular Therapy,2019,27(5):986-998. [42] LIU K,SUN B,YOU H,et al.Dual sgRNA-directed gene deletion in basidiomycete Ganoderma lucidum using the CRISPR/Cas9 system[J].Microbial Biotechnology,2020,13(2):386-396. |