菌落突变株与细菌适应性生存关系研究进展

doi:10.16431/j.cnki.1671-7236.2017.11.027

摘要/Abstract

摘要：

小菌落突变株（small colony variants，SCVs）是细菌正常生长周期中的一种细菌亚群，它在各种不利条件下可被选择出现。其生化特征表现为生长缓慢、菌落形态不规则、生化特性异常，这使得SCVs的分离鉴定较困难。临床上，SCVs可引起慢性持续性感染，而不引起宿主强烈的免疫反应，且对抗菌药物产生严重的耐药性。文章对SCVs在临床上的表型分类、与宿主免疫反应的关系及抗菌药物对其影响进行综述，以期为SCVs的深入研究提供理论支持。

关键词: 小菌落突变株; 表型; 免疫反应; 耐药性

Abstract:

Small colony variants (SCVs) have been shown to be part of the regular growth cycle, which are highly dynamic or stable and can be selected during various harsh conditions. The features of SCVs include slow growth, colony morphology irregular and biochemical characteristics abnormal, making the separation and identification of SCVs into trouble. SCVs can cause chronic persistent infection, but not lead to strong immune response to host. Furthermore, SCVs are serious resistant to antibacterials normally. In this paper, we introduce the phenotype classification of SCVs, the relationship with the host's immune response and the effects of antibacterials on SCVs, which will provide theoretical support for further research of SCVs.

Key words: small colony variants; phenotype; immune response; antibiotics resistance

中图分类号:

R446.5

高翔, 郭玉茹, 杨杰, 黄程程, 田春莲, 宏伟, 刘明春. 菌落突变株与细菌适应性生存关系研究进展[J]. 《中国畜牧兽医》, 2017, 44(11): 3300-3305.

GAO Xiang, GUO Yu-ru, YANG Jie, HUANG Cheng-cheng, TIAN Chun-lian, HONG Wei, LIU Ming-chun. Research Progress on Adaptive Survival Relationship Between Small Colony Variants and Bacteria[J]. , 2017, 44(11): 3300-3305.

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