螺旋藻多糖与银杏叶提取物复方对四氧嘧啶模型小鼠的降血糖作用

doi:10.16431/j.cnki.1671-7236.2019.07.036

Abstract

Abstract:

The aim of this experiment was to study the hypoglycemic effect of different proportions of polysaccharide from Soirulina platensis (PSP) and Ginkgo biloba extract (GBE).SPF Kunming male mice were selected for the experiment.Diabetic model was made by intraperitoneal injection of 0.2 mL at a concentration of 200 mg/(kg·d) for 5 consecutive days.The model was successfully constructed when the fasting blood glucose was greater than 11.1 mmol/L by tail-cut blood sampling.Then mice were randomly divided into blank control group,model group,positive control group,group P (PSP),group F (Ginkgo biloba flavone),group L(Ginkgo biloba lactones) and composite treatment groups that were PSP and GBE mixture of 1:1 (CP₁ group),2:1 (CP₂ group) and 1:2 (CP₃ group),10 mice in each group.Each mice in the control and CY groups was given 2.5 mg/(kg·d) glibenclamide,and mice in the other groups were given 200 mg/(kg·d) corresponding drugs once a day for 30 d continuously.The blood glucose value,body weight,spleen index,thymus index,liver glycogen and other indicators were measured.The results showed that compared with the model group,the body weight of mice in the drug groups was extremely significantly increased (P<0.01).The efficacy of compound drug groups was higher than that of single drug groups.Spleen and thymus indexes and liver glycogen content were extremely significantly increased (P<0.01),while the blood glucose level was extremely significantly decreased (P<0.01).Among them,the CP₂ group showed the greatest drop in blood glucose,and the hypoglycemic rate was 52.14% and the increase of hepatic glycogen was 61.88%.In conclusion,polysaccharide from Soirulina platensis and Ginkgo biloba effective components had synergistic effect on hyperglycemic mice induced by alloxan and had obvious hypoglycemic effect.

Key words: polysaccharide from Soirulina platensis (PSP); Ginkgo biloba extract (GBE); alloxan; mice; hypoglycemic

CLC Number:

R283

YU Leiyan, SUI Junxia, LI Huatao, DONG Junjie, GAO Shansong. Hypoglycemic Effect of Polysaccharide from Soirulina platensis and Ginkgo biloba Extract Compound on Alloxan-induced Model Mice[J]. , 2019, 46(7): 2176-2182.

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Hypoglycemic Effect of Polysaccharide from Soirulina platensis and Ginkgo biloba Extract Compound on Alloxan-induced Model Mice

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