细菌耐药性研究进展

doi:10.16431/j.cnki.1671-7236.2015.12.038

Abstract

Abstract: Antibiotic resistance of bacteria is a major problem in the clinical treatment of infectious diseases,and it has received the extensive attention.Bacteria producing inactivated enzyme or passivated enzyme is a mainly way to acquire resistance.Besides,the mechanisms of cell wall permeability barrier,efflux pump and target changes are existed,these mechanisms interact to the level of the bacterial antibiotic resistance.With the clinical application of new antibiotic,the new resistant mechanisms emerge and the antibiotic-resistant bacteria are widespread.The study of bacterial resistance mechanisms has instructional meaning for antibiotic-resistant bacteria control and new drug development.We elaborated the bacterial resistance from the origin of the resistance,mechanisms,characteristics and test method in this article.

Key words: bacteria; antibiotics; resistance; resistance mechanism

CLC Number:

S852.61

ZHU Zhen, CAO Ming-ze, ZHANG Ji-li, ZHOU Xu-zheng, LI Bing, ZHANG Ji-yu. Research Progress on Bacterial Resistance[J]. , 2015, 42(12): 3371-3376.

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