miRNA合成途径研究进展

doi:10.16431/j.cnki.1671-7236.2015.12.012

Abstract

Abstract: miRNA is a kind of 22 nt non-coding small RNA,which recognizes the target mRNA by complementary base pairing,and regulates the gene posttranscriptional expression using RNAi silencing mechanism.miRNA exists in animals,plants,viruses and various microorganism,and its expression is under the strict spatial-temporal regulation.Previous studies have showed the miRNA plays a key role in the regulation of tissue development,cell differentiation,apoptosis and cancer.The canonical biogenesis pathways include the process of the microprocessor in nucleus,nuclear export,Dicer dicing in cytoplasm and the generation of the miRISC complex.Besides,there are other synthetic pathways such as mirtron pathway,tRNA pathway and endogenous siRNA pathway.For providing a reference for the research and the application of the miRNA,this review summarizes the biosynthetic pathways of the miRNA.

Key words: miRNA; biosynthetic pathway; miRISC; tRNA pathway; endogenous siRNA pathway

CLC Number:

ZHAO Jing-wen, CHEN Guo-rong, WU Hui-guang. Research Progress on miRNA Biosynthetic Pathways[J]. , 2015, 42(12): 3186-3191.

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Research Progress on miRNA Biosynthetic Pathways

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