选择信号分析及其对绵羊功能基因的挖掘进展

doi:10.16431/j.cnki.1671-7236.2023.12.016

Abstract

Abstract: Through long-term natural and artificial selection,sheep have developed a rich and diverse variety of breeds that provide humans with meat,milk,wool,fur and other living items.Selection is accompanied by the generation of selection signals,such as population differentiation,decreased genomic diversity and the presence of high-frequency alleles in regions with long-range extended haplotype purity in selected regions.For different types of selection signals,corresponding analysis methods have been derived,such as population differentiation-based analysis,genomic heterozygosity-based analysis,haplotype and linkage disequilibrium-based analysis,and allele frequency profile-based analysis.In recent years,with the development of high-throughput sequencing technology,researchers have been able to mine a large number of functional genes associated with economic traits by performing selection signal analysis in sheep,providing more genetic information for sheep molecular breeding.The author introduces the classification and further presents the advances in utilizing these methods to screen sheep functional genes,the prospects of application and research are predicated on selection signal analysis,which provides valuable information for further applied research of selection signal analysis in sheep genetic breeding.

Key words: sheep; selection signals; functional genes

CLC Number:

S813.3

ZHANG Yanwei, YU Lijuan, XU Xinming, ABULAIZI Aminiguli, XIE Mengwan, TANG Liping, ZHENG Peiyu, DI Jiang. Advance on Selection Signal Analysis and Its Exploration for Functional Genes in Sheep[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(12): 4935-4946.

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Advance on Selection Signal Analysis and Its Exploration for Functional Genes in Sheep

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