贾第虫包囊壁形成及囊壁蛋白研究进展

doi:10.16431/j.cnki.1671-7236.2023.05.033

Abstract

Abstract: Giardia duodenalis (G.duodenalis) is a common zoonotic protozoan parasite that infects the small intestines of humans,livestock,dogs,cats and other mammals.Giardiasis which caused by G.duodenalis has been noted as one of the neglected diseases endangering human health by the World Health Organization.The intestinal protozoan parasite Giardia has a simple life cycle consisting of disease causing trophozoites and infectious cysts.Giardia trophozoites differentiate into infectious cysts in response to hostile environment (either low cholesterol conditions or alkaline pH and high bile conditions). Encystment is crucial for Giardia’s survival,transmission and pathogenesis.Giardiasis is often caused by the host ingestion of infectious cysts-contaminated food and water.The cyst wall is an important shield for Giardia cysts to resist adverse external environment,maintain their viability and infective activity.About 40% of the encapsulated wall is composed of proteins and the rest is carbohydrates such as N-acetylgalactosamine and lipids.It is shown that the cyst wall of Giardia mainly contains three cyst wall proteins (CWP1,CWP2 and CWP3).Cyst wall proteins not only play an important role in maintaining the viability of the cyst,but also has important value in the diagnosis of giardiosis and the development of oral vaccine.This review mainly introduced the composition and formation of Giardia cyst wall,the induction and regulation of encystation,and the research advances on cyst wall proteins in disease diagnosis and vaccines development,in order to provide reference for the follow-up related research.

Key words: Giardia duodenalis; cyst wall protein; diagnosis; oral vaccine

CLC Number:

S852.7

YU Xingang, YUAN Kaijian, MU Xuanru, WANG Hongcai, QI Nanshan, ZHANG Haoji. Research Progress on the Formation of Cyst Wall and Cyst Wall Proteins of Giardia[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 2061-2068.

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Research Progress on the Formation of Cyst Wall and Cyst Wall Proteins of Giardia

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