脂联素及其受体激动剂在禽脂肪性肝病中的应用展望

doi:10.16431/j.cnki.1671-7236.2022.02.036

Abstract

Abstract: Adiponectin is a hormone that can participate in the regulation of glucose and lipid metabolism, energy regulation, immune response, resistance to inflammation, oxidative stress and apoptosis.Avian fatty liver disease is lipid metabolism disorder, hepatocyte steatosis and inflammatory reaction caused by abnormal lipid metabolic pathways such as fatty acid synthesis and esterification, fatty acid transport, fatty acid oxidation, lipolysis and utilization in avian liver.This paper introduces adiponectin and its molecular structure, adiponectin receptor and its involved signal pathways, and focuses on the regulatory role and mechanism of adiponectin on liver lipid metabolism, inflammation, oxidative stress, hepatocyte apoptosis and autophagy, as well as the physiological role of adiponectin receptor agonists.At the same time, combined with the occurrence and development mechanism of avian fatty liver disease, the application prospect of adiponectin and its receptor agonists was prospected.This article provides a new idea for the prevention and treatment of fatty liver disease in poultry and even other animals.

Key words: adiponectin; adiponectin receptor agonists; liver; avian; fatty liver disease

CLC Number:

S852

CUI Chengyu, MA Ben, ZHAO Jiahui, ZHAO Zijuan, CHEN Yu, CAO Zhongzan, LUAN Xinhong. Application Prospect of Adiponectin and Its Receptor Agonists in Avian Fatty Liver Disease[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(2): 738-745.

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Application Prospect of Adiponectin and Its Receptor Agonists in Avian Fatty Liver Disease

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