China Animal Husbandry and Veterinary Medicine ›› 2022, Vol. 49 ›› Issue (2): 579-586.doi: 10.16431/j.cnki.1671-7236.2022.02.019
• Nutrition and Feed • Previous Articles Next Articles
WEI Wenzhuo1,2, LIANG Zhenhua1, WU Yan1, LIU Jingbo2, PI Jinsong1, ZHANG Hao1
Received:
2021-09-10
Published:
2022-01-27
CLC Number:
WEI Wenzhuo, LIANG Zhenhua, WU Yan, LIU Jingbo, PI Jinsong, ZHANG Hao. Effects of Exosomes on Animal Intestinal Health and Its Research Methods[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(2): 579-586.
[1] FAROOQI A A, DESAI N N, QURESHI M Z, et al. Exosome biogenesis, bioactivities and functions as new delivery systems of natural compounds[J]. Biotechnology Advances, 2018, 36(1): 328-334. [2] 王海龙, 陈婷, 张永亮. 乳外泌体: 新的肠道健康调节因子[J]. 中国生物化学与分子生物学报, 2020, 36(12): 1421-1430. WANG H L, CHEN T, ZHANG Y L. Milk—derived exosomes: Novel regulatory factors for intestinal health[J]. Chinese Journal of Biochemistry and Molecular Biology, 2020, 36(12): 1421-1430. (in Chinese) [3] JENJAROENPUN P, KREMENSKA Y, NAIR V M, et al. Characterization of RNA in exosomes secreted by human breast cancer cell lines using next-generation sequencing[J]. PeerJ, 2013, 1: e201. [4] FRYDRYCHOWICZ M, KOLECKA-BEDNARCZYK A, MADEJCZYK M, et al. Exosomes-structure, biogenesis and biological role in non-small-cell lung cancer[J]. Scandinavian Journal of Immunology, 2015, 81(1): 2-10. [5] KAO C Y, PAPOUTSAKIS E T. Extracellular vesicles: Exosomes, microparticles, their parts, and their targets to enable their biomanufacturing and clinical applications[J]. Current Opinion in Biotechnology, 2019, 60(1): 89-98. [6] ZHANG J, LI S, LI L, et al. Exosome and exosomal microRNA: Trafficking, sorting, and function[J]. Genomics, Proteomics & Bioinformatics, 2015, 13(1): 17-24. [7] AVILA-CALDERÓN E D, ARAIZA-VILLANUEVA M G, CANCINO-DIAZ J C, et al. Roles of bacterial membrane vesicles[J]. Archives of Microbiology, 2015, 197(1): 1-10. [8] CHANG X, WANG S L, ZHAO S B, et al. Extracellular vesicles with possible roles in gut intestinal tract homeostasis and IBD[J]. Mediators of Inflammation, 2020, 2020: 1945832. [9] SOMMER F, ANDERSON J M, BHARTI R, et al. The resilience of the intestinal microbiota influences health and disease[J]. Nature Reviews Microbiology, 2017, 15(10): 630-638. [10] VAN NIEL G, RAPOSO G, CANDALH C, et al. Intestinal epithelial cells secrete exosome-like vesicles[J]. Gastroenterology, 2001, 121(2): 337-349. [11] AYYAR K K, MOSS A C. Exosomes in intestinal inflammation[J]. Frontiers in Pharmacology, 2021, 12: 658505. [12] 黄佳铭, 杨冬雪, 李晓曦, 等. 肠道黏膜免疫与炎症小体的研究进展[J]. 微生物与感染, 2019, 14(2): 113-123. HUANG J M, YANG D X, LI X X, et al. Advances in intestinal mucosal immunity and inflammatory bodies[J]. Journal of Microbes and Infections, 2019, 14(2): 113-123. (in Chinese) [13] MORELLI A E, LARREGINA A T, SHUFESKY W J, et al. Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells[J]. Blood, 2004, 104(10): 3257-3266. [14] ZHOU F, PAZ H A, SADRI M, et al. Dietary bovine milk exosomes elicit changes in bacterial communities in C57BL/6 mice[J]. American Journal of Physiology Gastrointestinal and Liver Physiology, 2019, 317(5): 618-624. [15] BUI T M, SUMAGIN R. Progressing from recurring tissue injury to genomic instability: A new mechanism of neutrophil pathogenesis[J]. DNA and Cell Biology, 2019, 38(8): 747-753. [16] TENG Y, REN Y, SAYED M, et al. Plant-derived exosomal microRNAs shape the gut microbiota[J]. Cell Host & Microbe, 2018, 24(5): 637-652. [17] YU S, ZHAO Z, XU X, et al. Characterization of three different types of extracellular vesicles and their impact on bacterial growth[J]. Food Chemistry, 2019, 272(1): 372-378. [18] SUBRAMANIAN S, GENG H, TAN X D. Cell death of intestinal epithelial cells in intestinal diseases[J]. Acta Physiologica Sinica, 2020, 72(3): 308-324. [19] CHENG W, WANG K, ZHAO Z, et al. Exosomes-mediated transfer of miR-125a/b in cell-to-cell communication: A novel mechanism of genetic exchange in the intestinal microenvironment[J]. Theranostics, 2020, 10(17): 7561-7580. [20] GAO H N, GUO H Y, ZHANG H, et al. Yak-milk-derived exosomes promote proliferation of intestinal epithelial cells in an hypoxic environment[J]. Journal of Dairy Science, 2019, 102(2): 985-996. [21] ZHOU Y, YU Z, WANG X, et al. Exosomal circRNAs contribute to intestinal development via the VEGF signalling pathway in human term and preterm colostrum[J]. Aging, 2021, 13(8): 11218-11233. [22] 赵伟. 外泌体环状RNA CDR1as调控大鼠肠神经嵴干细胞增殖、凋亡及迁移的实验研究[D]. 沈阳: 中国医科大学, 2019. ZHAO W. Exosomal circular RNA CDR1as regulates proliferation, apoptosis and migration of rat intestinal neural crest stem cells[D]. Shenyang: China Medical University, 2019. (in Chinese) [23] XIE M Y, HOU L J, SUN J J, et al. Porcine milk exosome miRNAs attenuate LPS-induced apoptosis through inhibiting TLR4/NF-κB and p53 pathways in intestinal epithelial cells[J]. Journal of Agricultural and Food Chemistry, 2019, 67(34): 9477-9491. [24] CHEN T, XIE M Y, SUN J J, et al. Porcine milk-derived exosomes promote proliferation of intestinal epithelial cells[J]. Scientific Reports, 2016, 6(1): 1-12. [25] MELNIK B C, JOHN S M, SCHMITZ G. Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth[J]. Nutrition Journal, 2013, 12: 103. [26] KARIN M, CLEVERS H. Reparative inflammation takes charge of tissue regeneration[J]. Nature, 2016, 529(7586): 307-315. [27] DENG F, YAN J, LU J, et al. M2 macrophage-derived exosomal miR-590-3p attenuates DSS-induced mucosal damage and promotes epithelial repair via the LATS1/YAP/β-catenin signalling axis[J]. Journal of Crohn's & Colitis, 2021, 15(4): 665-677. [28] 王才霞, 刘成霞. 外泌体在炎症性肠病中的研究进展[J]. 重庆医科大学学报, 2020, 45(9): 1323-1326. WANG C X, LIU C X. Research progress of exosomes in inflammatory bowel disease[J]. Journal of Chongqing Medical University, 2020, 45(9): 1323-1326. (in Chinese) [29] LIU H, LIANG Z, WANG F, et al. Exosomes from mesenchymal stromal cells reduce murine colonic inflammation via a macrophage-dependent mechanism[J]. JCI Insight, 2019, 4(24): e131273. [30] WANG G, YUAN J, CAI X, et al. HucMSC-exosomes carrying miR-326 inhibit neddylation to relieve inflammatory bowel disease in mice[J]. Clinical and Yranslational Medicine, 2020, 10(2): e113. [31] MIYAKE H, LEE C, CHUSILP S, et al. Human breast milk exosomes attenuate intestinal damage[J]. Pediatric Surgery International, 2020, 36(2): 155-163. [32] LIVSHITS M A, KHOMYAKOVA E, EVTUSHENKO E G, et al. Isolation of exosomes by differential centrifugation: Theoretical analysis of a commonly used protocol[J]. Scientific Reports, 2015, 5: 17319. [33] GU H, CHEN C Q, HAO X X, et al. Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis[J]. The Journal of Clinical Investigation, 2016, 126(12): 4537-4553. [34] ZHANG Y, BI J, HUANG J, et al. Exosome: A review of its classification, isolation techniques, storage, diagnostic and targeted therapy applications[J]. International Journal of Nanomedicine, 2020, 15(1): 6917-6934. [35] LIU Z J, GAN L, ZHANG T T, et al. Melatonin alleviates adipose inflammation through elevating α-ketoglutarate and diverting adipose-derived exosomes to macrophages in mice[J]. Journal of Pineal Research, 2018, 64(1): 1-47. [36] TASSETTO M, KUNITOMI M, ANDINO R. Circulating immune cells mediate a systemic RNAi-based adaptive antiviral response in drosophila[J]. Cell, 2017, 168(2): 186-199. [37] BÖING A N, VAN DER POL E, GROOTEMAAT A E, et al. Single-step isolation of extracellular vesicles by size-exclusion chromatography[J]. Journal of Extracellular Vesicles, 2014, 3(1): 1-12. [38] TÓTH E Á, TURIÁK L, VISNOVITZ T, et al. Formation of a protein corona on the surface of extracellular vesicles in blood plasma[J]. Journal of Extracellular Vesicles, 2021, 10(11): e12140. [39] TSCHUSCHKE M, KOCHEROVA I, BRYJA A, et al. Inclusion biogenesis, methods of isolation and clinical application of human cellular exosomes[J]. Journal of Clinical Medicine, 2020, 9(2): 436-455. [40] YANG X X, SUN C, WANG L, et al. New insight into isolation, identification techniques and medical applications of exosomes[J]. Journal of Controlled Release, 2019, 308(1): 119-129. [41] CHEN P, RUAN A, ZHOU J, et al. Extraction and identification of synovial tissue-derived exosomes by different separation techniques[J]. Journal of Orthopaedic Surgery and Research, 2020, 15(1): 97. [42] GARDINER C, FERREIRA Y J, DRAGOVIC R A, et al. Extracellular vesicle sizing and enumeration by nanoparticle tracking analysis[J]. Journal of Extracellular Vesicles, 2013, 2(2): 46-58. [43] XIA F, DING F, LV Y, et al. A high efficient method to isolate exosomes from small intestinal epithelium[J]. Molecular Biotechnology, 2019, 61(5): 325-331. [44] SHANG A, GU C, WANG W, et al. Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p/miR-506-3p-TGF-β1 axis[J]. Molecular Cancer, 2020, 19(1): 117-132. [45] TERESA L R, SÁNCHEZ-ABARCA L I, MUNTIÓN S, et al. MSC surface markers (CD44, CD73, and CD90) can identify human MSC-derived extracellular vesicles by conventional flow cytometry[J]. Cell Communication and Signaling, 2016, 14: 2. [46] TERESA L, RAMO S, LIU S, et al. MSC surface markers (CD44, CD73, and CD90) can identify human MSC-derived extracellular vesicles by conventional flow cytometry[J]. Cell Communication & Signaling, 2016 9(1): 296-311. [47] LIU T, ZHANG Q, ZHANG J, et al. EVmiRNA: A database of miRNA profiling in extracellular vesicles[J]. Nucleic Acids Research, 2019, 47(D1): 89-93. [48] ZHANG L, LEI Q, WANG H, et al. Tumor-derived extracellular vesicles inhibit osteogenesis and exacerbate myeloma bone disease[J]. Theranostics, 2019, 9(1): 196-209. [49] LI S, LI Y, CHEN B, et al. exoRBase: A database of circRNA, lncRNA and mRNA in human blood exosomes[J]. Nucleic Acids Research, 2018, 46(D1): 106-112. [50] KEERTHIKUMAR S, CHISANGA D, ARIYARATNE D, et al. ExoCarta: A web-based compendium of exosomal cargo[J]. Journal of Molecular Biology, 2016, 428(4): 688-692. [51] HARASZTI R A, DIDIOT M C, SAPP E, et al. High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources[J]. Journal of Extracellular Vesicles, 2016, 5(1): 1-15. [52] KALRA H, SIMPSON R J, JI H, et al. Vesiclepedia: A compendium for extracellular vesicles with continuous community annotation[J]. PLoS Biology, 2012, 10(12): e1001450. [53] MURILLO O D, THISTLETHWAITE W, ROZOWSKY J, et al. exRNA atlas analysis reveals distinct extracellular RNA cargo types and their carriers present across human biofluids[J]. Cell, 2019, 177(2): 463-477. |
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